IMPACT OF SERUM 25(OH) VITAMIN D LEVEL ON MORTALITY IN PATIENTS WITH COVID-19 IN TURKEY
JNutr Health Aging. 2020;
S. KARAHAN, F. KATKAT, Bagcilar Egitim ve Arastiima Hastanesi, Turkey.
Corresponding author: Serkan Karahan, Bagcilar Egitim ve Arastirma Hastanesi, Turkey, drserkankarahan at gmail.com
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Background:
Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality.
Methods:
This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory data, and 25(OH) vitamin D levels were recorded for each study participant. Patients were stratified into different vitamin D groups; Normal (Serum 25(OH) vitamin D level >30 ng/mL), Vitamin D insufficiency (21-29 ng/mL), and deficiency (<20 ng/ mL). The severity of COVID was classified according to the Chinese Clinical Guideline for classification of COVID-19 severity. Mortality data were determined for participants. Univariate and multivariate Logistic regression analysis was performed to determine independent predictors of in-hospital mortality.
Results:
Overall, 149 C〇VID-19 patients (females 45.6%，mean age 63.5 土 15.3 (range 24-90 years) years) were included. Forty- seven patients (31.5%) had moderate COVID-19, whereas 102 patients (68.5%) had severe-critical COVID-19. The mean 25(〇H) vitamin D level was 15.2 土 10.3 ng/mL. Thirty-four (22.8%) and 103 (69.1%) patients had vitamin D insufficiency and deficiency, respectively. Mean serum 25(OH) vitamin D level was significantly lower in patients with severe-critical COVID-19 compared with moderate COVID-19 (10.1 土 6.2 vs. 26.3 土 8.4 ng/mL, respectively, p<0.001). Vitamin D insufficiency was present in 93.1% of the patients with severe-critical COVID-19. Multivariate logistic regression analysis revealed that only lymphocyte count, white blood cell count, serum albumin and, 25(OH) vitamin D level were independent predictors of mortality.
Conclusion:
Serum 25(OH) vitamin D was independently associated with mortality in COVID-19 patients.