The effect of high-dose vitamin D on bone mineral density and bone turnover markers in postmenopausal women with low bone mass-a randomized controlled 1-year trial.
Osteoporos Int. 2011 Sep 10.
Grimnes G, Joakimsen R, Figenschau Y, Torjesen PA, Almås B, Jorde R.
Tromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, 9037, Tromsø, Norway, guri.grimnes at unn.no.
Vitamin D is widely used in osteoporosis treatment, although the optimal dose is not known. This 1-year clinical study among 297 women aged 50-80 years old showed that a vitamin D(3) dose of 6,500 IU/day was not better than the standard dose of 800 IU/day in improving bone mineral density (BMD) in the hip and spine.
INTRODUCTION:
The purpose of this study was to determine whether a high dose of vitamin D(3) was better than the standard dose in improving BMD and reducing bone turnover in postmenopausal women with reduced bone mass.
METHODS:
The study was a 1-year randomized double-blind controlled trial comparing high-dose vitamin D(3) with the standard dose. Postmenopausal women (n?=?297) with a BMD T-score???-2.0 in either lumbar spine (L2-4) or total hip were included and randomized to 6,500 IU vitamin D(3)/day (20,000 IU twice per week?+?800 IU/day) or 800 IU vitamin D(3)/day (placebo twice per week?+?800 IU/day). Both groups were given 1,000 mg elemental calcium/day. The primary endpoint was a change in BMD in total hip and lumbar spine (L2-4).
RESULTS:
After 1 year, serum 25-hydroxyvitamin D (25(OH)D) increased [mean (SD)] from
- 71 (23) to 185 (34)?nmol/l and from
- 71 (22) to 89 (17)?nmol/l in the high- and standard-dose vitamin D groups, respectively.
BMD at all measurement sites was unchanged or slightly improved with no significant differences between the groups.
Although bone turnover was reduced in both groups, the more pronounced reduction in serum levels of the bone formation marker P1NP in the standard-dose group may indicate that this treatment was more efficient. Adverse events did not differ between the groups.
CONCLUSIONS:
One year treatment with 6,500 IU vitamin D(3)/day was not better than 800 IU/day regarding BMD in vitamin D-replete postmenopausal women with reduced bone mass and was less efficient in reducing bone turnover.
PMID: 21909730
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6,500 IU of vitamin D + 1000 mg of Calcium
Resulted in vitamin D in blood 28 ng ==>74 ng but no extra bone density
Wonder if the patients were all drinking soft water (lacking Magnesium)
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See also Vitamin D Life - notice importance of co-factors - such as Magnesium and Vitamin K
- All items in Bone Health and Vitamin D 82 items as of Sept 2011
- Overview Osteoporosis and vitamin D
- It appears that to TREAT Osteoporosis:
- Calcium OR vitamin D is OK,
- Calcium + vitamin D is GOOD,
- Calcium + vitamin D + other co-factors is GREAT
- All items in category Bone - Osteoporosis 83 items Aug 2011
- Lowest cost osteoporosis treatment in China was vitamin D and Calcium – Oct 2010
- Evidence-based Review of Vitamin D -2010 Osteoporosis Grade = B
- Cochrane review finds that Vitamin D helps treat Osteoporosis – Feb 2010
- 2000 to 3000 IU required to start to help with Osteoporis – June 2010
- Do not just take more Calcium if you fear Osteoporosis- Mercola Dec 2010 from book: The Calcium Lie
- BMD improved with 800 mg Calcium, 400 IU of vitamin D, and 100 ug of vitamin K– April 2011
- 400 IU of Vitamin D Magnesium and Calcium helped Twin bones – Feb 2011
- 400 IU is the least amount of vitamin D - wonder how low of vitamin D needed if take all of the co-factors
- Overview of Magnesium
- Overview of: Vitamin K and Vitamin D
- 4000 IU Vitamin D intervention helped elderly bones – March 2010
- Is it ethical to not give vitamin D in osteoporosis trials– NEJM Sept 2010
- National Osteoporosis Foundation on Vitamin D - more than 30 ng - 2010
- Vitamin D recommendations by Osteoporosis Canada - Sept 2010 800-2000 IU daily, 10,000 IU is probably safe
- Review of vitamin D pathways to bone health - July 2010 with many summaries of vitamin D INTERVENTIONS
- Low Calcium and vitamin D makes osteomalacia but either makes osteoporosis – Sept 2010
- Prefer more than 30 ng of Vitamin D and 700 mg Calcium for Osteoporosis – Mar 2011
- Low vitamin D before orthopedic surgery – dark skin 5X more likely – Oct 2010
- suspect not just dark skin, but those also at risk of being low on vitamin D: sunlight, elderly, medical problems, etc.
- Osteoporosis reduced by 800 or more IU of vitamin D - July 2010
- 4000 IU Vitamin D intervention helped elderly bones – March 2010
- 890 IU of vitamin D and 1200 mg Calcium improved bone density – July 2010
- Both Calcium AND vitamin D needed to prevent elderly fractures – Sept 2010
- Calcium and just 900 IU of vitamin D can improve Bone Density – July 2010
- Low vitamin D may account for half of the reasons for osteomalacia – Oct 2010
- Calcium level somewhat higher due to vitamin D might be a problem – June 2010
- Vitamin D and Calcium Absorption – Sept 2010
- Calcium citrate and more than 800 IU of vitamin D to treat Osteoporosis – Mar 2011
- 1800 to 4000 IU vitamin D to get 30 to-44 ng no risk osteo - July 2010.pdf file