Vitamin D Receptor Gene Polymorphism and susceptibility to Asthma: meta-analysis based on 17 case–control studies
Annals of Allergy, Asthma & Immunology https://doi.org/10.1016/j.anai.2019.10.014
Masoud Hassanzadeh Makoui PhD1 DanialImani PhD1 Morteza Motallebnezhad PhD234 MaryamAzimiPhD56 BahmanRazi PhD7
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
It would appear that this study has grossly underestimated the association of Asthma and VDR
Currently unable to access the PDF to understand why
Items in both categories Breathing and Vitamin D Receptor are listed here:
- Mucosal membranes (mouth, lungs, nose, intestines, etc) can activate Vitamin D – July 2020
- Respiratory problems in Children 1.4X more likely if poor Vitamin D receptor – April 2020
- Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019
- Microbiomes of both gut and airway are affected by Vitamin D and Vitamin D Receptor – Nov 2018
- Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019
- Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Best supplements for hay fever (Quercetin, which activates the Vitamin D receptor) - June 2019
- Upper respiratory infection associated with poor Vitamin D Receptor – Oct 2018
- Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019
- Gut and airway bionome are affected by Vitamin D and Vitamin D Receptor – Nov 2018
- Pneumonia in Egyptian Children 3.6 X more likely if poor Vitamin D Receptor – Aug 2018
- Respiratory Tract Infections in children 7.4 X more likely if poor Vitamin D Receptor – 2008
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Vitamin D Receptor problems occur 5 times for often with Nasal polyposis – Nov 2016
- Vitamin D effects on lung immunity and respiratory diseases – 2011
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015
- 2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015
- Strong Vitamin D deficiency associations in Asthma patients – Nov 2014
Items in both categories Meta-analysis and Vitamin D Receptor are listed here:
- Spinal disc degeneration 1.8X more likely if poor Vitamin D Receptor – mata-analysis Sept 2020
- Osteoporosis Risk varies with Vitamin D Receptor – meta-analysis July 2020
- Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Parkinson’s disease 1.6X more likely if a poor Vitamin D Receptor – meta-analysis Jan 2020
- Risk of Multiple Sclerosis varies with the Vitamin D Receptor – meta-analysis Dec 2019
- Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019
- Kidney failure 1.1 X more likely if poor Vitamin D Receptor – meta-analysis Dec 2019
- Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019
- Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019
- Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019
- Parkinson’s disease 20 percent more likely in Asians if poor Vitamin D Receptor – meta-analysis April 2019
- Osteoporosis 15 percent more likely if poor Vitamin D receptor – meta-analysis Dec 2018
- Psoriasis risk in Caucasians is 1.3 X higher if poor Vitamin D Receptor – meta-analysis Nov 2018
- Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis July 2018
- Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017
- Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
- Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Oct 2016
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014
- Multiple Sclerosis and the Vitamin D Receptor – meta-analysis July 2014
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
- Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
- Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
Background
During the last decade, several studies have evaluated the potential association between vitamin D receptor (VDR) gene polymorphism and susceptibility to asthma. In spite of valuable finding, the results are still contradictory. Therefore, a comprehensive meta-analysis not only solves discrepancies but provides a clue for future projects.
Objective
This meta-analysis was performed to identify whether VDR gene polymorphisms (FokI (rs2228570) or / and TaqI (rs731236) or / and BsmI (rs1544410) or / and ApaI (rs7975232)) play role in the risk of asthma.
Methods
The electronic search of web of science, Scopus, and PubMed databases were systematically conducted from their inception until Jun 2019, to identify all published studies. Eligibility of studies was confirmed by precise inclusion and exclusion criteria and the resultant studies were analyzed.
Results
A total of 17 studies concerning to VDR gene polymorphisms and asthma risk were included in this meta-analysis. The results of pooled analysis revealed a statistical significant association between FokI SNP [
- dominant model (OR= 0.78, 95% CI, 0.62-0.98,
- random effect model) and allelic model (OR= 0.81, 95% CI, 0.67-0.98, random effect model)]
- and TaqI SNP [homozygote contract model (OR= 0.70, 95% CI, 0.54 - 0.89)]
with asthma risk. Moreover, subgroup analysis showed that ethnicity influences asthma risk in Asian, African and American populations.
The sensitivity analyses confirmed the stability of the results.
Conclusion
This meta-analysis suggests that VDR gene polymorphism is associated with the risk of asthma.