Loading...
 
Toggle Health Problems and D

Autism associated with low vitamin D and anti-MAG antibodies – Aug 2012

Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: Relation to autoimmunity

Gehan A Mostafa and Laila Y AL-Ayadhi
Journal of Neuroinflammation 2012, 9:201 doi:10.1186/1742-2094-9-201
Published: 17 August 2012

Background
Aside from the skeletal health affection, vitamin D deficiency has been implicated as a potential environmental factor triggering for some autoimmune disorders. Vitamin D might play a role in the regulation of the production of auto-antibodies. Immunomodulatory effects of vitamin D may act not only through modulation of T-helper cell function, but also through induction of CD4+CD25 high regulatory T-cells. We are the first to investigate the relationship between serum levels of 25-hydroxy vitamin D and anti-myelin-associated glycoprotein (anti-MAG) auto-antibodies in autistic children.

Methods
Serum levels of 25-hydroxy vitamin D and anti-MAG auto-antibodies were measured in 50 autistic children, aged between 5 and 12 years, and 30 healthy-matched children. Serum 25-hydroxy vitamin D levels 10--30 ng/mL and < 10 ng/mL were defined as vitamin D insufficiency and deficiency, respectively.

Results
Autistic children had significantly lower serum levels of 25-hydroxy vitamin D than healthy children (P < 0.001) with 40% and 48% being vitamin D deficient and insufficient, respectively.

Serum 25-hydroxy vitamin D had significant negative correlations with Childhood Autism Rating Scale (P < 0.001). Increased levels of serum anti-MAG auto-antibodies were found in 70% of autistic patients. Serum 25-hydroxy vitamin D levels had significant negative correlations with serum levels of anti-MAG auto-antibodies (P < 0.001).

Conclusions
Vitamin D deficiency was found in some autistic children and this deficiency may contribute to the induction of the production of serum anti-MAG auto-antibodies in these children.
However, future studies looking at a potential role of vitamin D in the pathophysiology and treatment of autism are warranted.
Image

Image

Provisional PDF is attached at the bottom of this page

2008 PDF by a common author is also attached at the bottom of this page
– – – – – – – – – – – – – – – – – – – – – – – – -

Summary by Vitamin D Life: Autistics

88% < 30 ng of vitamin D
70% had increased levels of serum anti-MAG auto-antibodies
This is the first mention of anti-MAG in Vitamin D Life
But there are many hits for anti-MAG and autism in Google 5000 as of Aug 2012

See also Vitamin D Life

Attached files

ID Name Comment Uploaded Size Downloads
1553 Egyptian Autism 2008.pdf admin 17 Aug, 2012 12:32 617.19 Kb 1003
1552 Autism Aug 2012.pdf PDF admin 17 Aug, 2012 12:32 1.10 Mb 1108
1551 anti-mag.jpg admin 17 Aug, 2012 12:31 15.42 Kb 1331
1550 Autism and vitmin D.jpg admin 17 Aug, 2012 12:31 12.74 Kb 1215
See any problem with this page? Report it (FINALLY WORKS)