PLGA nanoparticles as a platform for vitamin D-based cancer therapy
Beilstein J. Nanotechnol. 2015, 6, 1306–1318. doi:10.3762/bjnano.6.135
Maria J. Ramalho, Joana A. Loureiro, Bárbara Gomes, Manuela F. Frasco, Manuel A. N. Coelho and M. Carmo Pereira mcsp at fe.up.pt
LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were studied as drug delivery vehicles for calcitriol, the active form of vitamin D3. In vitro effects of calcitriol encapsulated in PLGA nanoparticles were evaluated with respect to free calcitriol on human pancreatic cell lines, S2-013 and hTERT-HPNE, and the lung cancer cell line A549. Encapsulated calcitriol retained its biological activity, reducing the cell growth. Cytotoxicity assays demonstrated that encapsulation of calcitriol enhanced its inhibitory effect on cell growth at a concentration of 2.4 μM for the S2-013 cells (91%) and for A549 cells (70%) comparared to the free calcitriol results. At this concentration the inhibitory effect on nontumor cells (hTERT-HPNE) decreased to 65%. This study highlights the ability of PLGA nanoparticles to deliver vitamin D3 into cancer cells, with major effects regarding cancer cell cycle arrest and major changes in the cell morphological features.
 Download the PDF from Vitamin D Life
See also Vitamin D Life
- Calcitriol category listing has
46 items along with related searches Items in both categories Calcitriol and Cancer are listed here:
- Active Vitamin D level should not be used for Prospective Studies of Cancer – Aug 2018
- Active vitamin D appears to treat cancer – more studies needed – June 2018
- Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018
- Cancer treated better when active vitamin d (calcitriol) is inside of PLGA nanoparticles – June 2015
- How active vitamin D (Calcitriol) deals with cancer – June 2015
Cancer treated better when active vitamin d (calcitriol) is inside of PLGA nanoparticles – June 20153743 visitors, last modified 17 Jun, 2018, This page is in the following categories (# of items in each category)Cancer211 Calcitriol 46 Attached files
ID Name Comment Uploaded Size Downloads 5609 PLGA.pdf PDF 2015 admin 24 Jun, 2015 18:17 7.72 Mb 561 5608 PLGA F5C.jpg admin 24 Jun, 2015 18:16 22.98 Kb 1094 5607 PLGA F4.jpg admin 24 Jun, 2015 18:15 20.36 Kb 1123 5606 PLGA F2.jpg admin 24 Jun, 2015 18:15 28.06 Kb 1486 See any problem with this page? Report it (FINALLY WORKS)