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Cognition in young adults not improved with vitamin D if already have enough – Nov 2011

Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.

PLoS One. 2011;6(11):e25966. Epub 2011 Nov 4.
Dean AJ a.dean at uq.edu.au , Bellgrove MA, Hall T, Phan WM, Eyles DW, Kvaskoff D, McGrath JJ.
Queensland Brain Institute, The University of Queensland, St Lucia, Australia

BACKGROUND:
Epidemiological research links vitamin D status to various brain-related outcomes. However, few trials examine whether supplementation can improve such outcomes and none have examined effects on cognition. This study examined whether Vitamin D supplementation led to improvements in diverse measures of cognitive and emotional functioning, and hypothesised that supplementation would lead to improvements in these outcomes compared to placebo.

METHODS/PRINCIPAL FINDINGS:
Healthy young adults were recruited to a parallel-arm, double-blind trial conducted at The University of Queensland. Participants were randomly allocated to receive Vitamin D (one capsule daily, containing 5000 IU cholecalciferol) or identical placebo capsule for six weeks. All participants and outcome assessors were blinded to group assignment.
Primary outcome measures assessed at baseline and 6 weeks were

  • working memory,
  • response inhibition and
  • cognitive flexibility.

Secondary outcomes were:

  • hallucination-proneness,
  • psychotic-like experiences, and
  • ratings of depression, anxiety and anger.

128 participants were recruited, randomised and included in primary analyses (vitamin D n = 63; placebo n = 65). Despite significant increases in vitamin D status in the active group, no significant changes were observed in working memory (F = 1.09; p = 0.30), response inhibition (F = 0.82; p = 0.37), cognitive flexibility (F = 1.37; p = 0.24) or secondary outcomes. No serious adverse effects were reported.

CONCLUSIONS:
Our findings indicate that vitamin D supplementation does not influence cognitive or emotional functioning in healthy young adults. Future controlled trials in targeted populations of interest are required to determine whether supplementation can improve functioning in these domains. Australian and New Zealand Clinical Trials Registry; ACTRN12610000318088.
PMID: 22073146

The PDF is attached to the bottom of this page
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All participants started with 30 ng vitamin D levels

People with cognitive problems typically have much lower levels

Would not anticipate much cognitive improvement when increasing fro 30 ng to 40 ng

See also Vitamin D Life

Attached files

ID Name Comment Uploaded Size Downloads
1188 cognition Vitamin D .pdf PDF admin 31 Mar, 2012 14:47 270.68 Kb 675
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