Association of Vitamin D Status With Coronary Artery Disease in Postmenopausal Women
Medicine (Baltimore) , 99 (11), e19544 Mar 2020, DOI: 10.1097/MD.0000000000019544
Rui Xu 1, Yan-Yan Li 2, Ling-Ling Ma 1, Hong-Ni Yang 1
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
Meta-analyses
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
Omega-3 Helps
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
Items in both categories Cardiovasular and women are listed here:
- Coronary Artery Disease 2.9 X more likely in postmenopausal women if Vitamin D deficient – March 2020
- Metabolic Syndrome associated with low vitamin D in abdominal obese women – Jan 2019
- Half of Women Over 50 Desperately Need This Potent Nutrient (Vitamin D) – April 2018
- Heart Disease 40 percent more likely in women having poor Vitamin D Binding Protein – Sept 2017
- Coronary Heart Disease 3 times more likely if endometriosis before age 40 (vitamin D not mentioned) – March 2016
- ALL of the top 10 health problems of women are associated with low vitamin D
- Off topic: CVD: the primary cause of death in senior women, is increasing – Nov 2012
Download the PDF from Vitamin D Life
The relationship between coronary artery disease (CAD) and low serum 25-hydroxyvitamin D (25(OH)D) levels has emerged. Postmenopausal (PM) women are at increased risk of CAD and vitamin D (VitD) deficiency. To investigate the relationship between CAD and VitD levels in PM women.This case-control study included 93 consecutive female patients aged 50 to 79 years old undergoing coronary angiography for evaluation of CAD and 119 age-matched controls. Serum 25(OH)D concentrations were classed as adequate (serum 25(OH)D: ≥20 ng/mL); insufficient (serum 25(OH)D: 10 to <20 ng/mL); and deficient (serum 25(OH)D: <10 ng/mL).
Major cardiovascular risk factors were also explored.CAD occurred in
- 67/127 (52.8%) patients with VitD deficiency;
- 21/66 (31.8%) patients that were VitD insufficient; and in
- 5/19 (26.3%) patients with adequate VitD levels.
Multivariate regression analysis suggested that a deficiency of VitD increased CAD (odds ratio = 2.891; 95% confidence interval = 1.459-7.139, P < .001).
VitD deficiency should be evaluated in PM women as a possible cause of CAD.
GrassrootsHealth description of the study
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