Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring:
A 6-Year Follow-up of a Randomized Clinical Trial.
JAMA Pediatr. 2019 Aug 5. doi: 10.1001/jamapediatrics.2019.2545
Note: Vitamin D was only given during the 3rd quarter of pregancy
Can expect much more improvement if start with more vitamin D much earlier in pregancy
Pages listed in BOTH Dental and Infants
- Teeth from 19th century London indicate that most children were Vitamin D Deficient - Oct 2019
- Half as many tooth enamel defects in child if 2400 IU Vitamin D in late pregnancy – RCT Aug 2019
- Half as many teeth problems if higher cord blood level of vitamin D – March 2019
- No tooth decay in children with adequate Vitamin D (small study) – June 2018
- Early tooth decay 1.9 X more likely if a poor Vitamin D receptor – July 2017
- Severe childhood dental problems 2.4 X more likely if breastfed for more than two years (low vitamin D) – June 2017
- Dental Caries risk in children cut in half if more than 20 nanogram of Vitamin D – Nov 2015
- Teeth enamel problems (MIH) 11 percent less likely with just 4 ng more vitamin D – Dec 2014
- 3X fewer infant dental caries if good level of vitamin D while pregnant – April 2014
- Severe tooth decay in children unless supplemented with Vitamin D drops – Oct 2013
- UVB added in classroom reduced cavities, increased height, increased academics. etc
- Dental caries cut in half by vitamin D, review of 24 old clinical trials – Nov 2012
- Children with severe caries were 2X more likely to have inadequate vitamin D – July 2012
Nørrisgaard PE1, Haubek D2, Kühnisch J3, Chawes BL1, Stokholm J1,4, Bønnelykke K1, Bisgaard H1.
1 Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark.
2 Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.
3 Department of Operative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians-Universität München, München, Germany.
4 Department of Pediatrics, Naestved Hospital, Naestved, Denmark.
IMPORTANCE:
Enamel defects of developmental origin affect up to 38% of schoolchildren and is recognized as a global public health challenge. The impaired enamel formation results in pain owing to hypersensitivity, posteruptive breakdowns, rapid caries progression, and extractions in some cases. The etiology is unknown; therefore, prevention is currently not possible.
OBJECTIVE:
To assess the association of a high-dose vitamin D supplementation in pregnant women with enamel defects and caries in their offspring.
DESIGN, SETTING, AND PARTICIPANTS:
Post hoc analysis of a double-blind, single-center, randomized clinical trial, the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort (COPSAC2010). Enrollment began March 2009 and included 623 women recruited at 24 weeks of pregnancy and 588 of their children. A dental examination was completed at age 6 years in 496 of 588 children (84%). Data were analyzed in 2018.
INTERVENTION:
High-dose vitamin D3 (2400 IU/d; N = 315) or matching placebo tablets (N = 308) from pregnancy week 24 to 1 week post partum. In addition, all women received 400 IU/d of vitamin D3 as part of standard care.
MAIN OUTCOMES AND MEASURES:
Enamel defect was defined as having at least 1 molar affected by demarcated opacity, enamel breakdown, and/or atypical restoration. Caries was defined as decayed, missing, or filled surfaces in both the deciduous and permanent dentitions (World Health Organization standard).
RESULTS:
The risk of enamel defects in the permanent dentition was lower in the offspring of mothers who received high-dose vitamin D supplementation during pregnancy compared with standard dose (15.1% [n = 26 of 172] vs 27.5% [n = 44 of 160]; odds ratio, 0.47; 95% CI, 0.27-0.81). A similar association was observed for the deciduous dentition (8.6% [n = 21 of 244] vs 15.9% [n = 40 of 252]; odds ratio, 0.50; 95% CI, 0.28-0.87). There was no association between supplementation and caries.
CONCLUSIONS AND RELEVANCE:
High-dose vitamin D supplementation during pregnancy was associated with approximately 50% reduced odds of enamel defects in the offspring. This suggests prenatal vitamin D supplementation as a preventive intervention for enamel defects, with a clinically important association with dental health.
Primary outcome of the study: 24% reduction in wheeze if mother started getting 2,400 IU doses at week 24
Reduced wheezing at age 3 was not statistically significant (p = 0.16)