Vitamin D-effective solar UV radiation, dietary vitamin D and breast cancer risk.
Int J Cancer. 2011 Mar 15;128(6):1425-33. doi: 10.1002/ijc.25463.
Edvardsen K, Veierød MB, Brustad M, Braaten T, Engelsen O, Lund E.
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway. ked at nilu.no
Vitamin D is well known for its important role in calcium and phosphor homeostasis. Recent research suggests that vitamin D also prevent some type of cancers. We studied solar vitamin D effective UV radiation (VD dose), dietary vitamin D, sun-seeking holidays, use of solarium, frequency of sunburn and breast cancer risk in a large population-based cohort study. A total of 41,811 women from the prospective Norwegian Women and Cancer Study, aged 40-70 years at baseline, were followed from 1997/1998 to 2007. Dietary vitamin D intake was calculated at baseline. Information on historical VD dose was used as a proxy for cutaneously obtained vitamin D status. Cox proportional hazards model was used. We adjusted for age, height, BMI, baseline menopausal status, use of hormone replacement therapy, use of oral contraception, alcohol, mother's history of breast cancer, mammography and parity. During 8.5 years of follow-up, 948 new cases of breast cancer were registered using data from the Norwegian Cancer Registry.
We found no significant associations between VD dose, or vitamin D intake, or sun-seeking holidays, or use of solarium, or frequency of sunburn, and breast cancer risk. Relative risks (95% confidence intervals) for highest versus lowest category were 1.17 (0.95-1.44), 0.95 (0.75-1.21), 1.07 (0.87-1.32), 0.93 (0.76-1.14) and 1.10 (0.89-1.36), respectively. Our results do not support an association between vitamin D status, and breast cancer risk.
Copyright © 2010 UICC. PMID: 20473950
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Response from author to a question by Vitamin D Life
Only one case just above 3,000 IU a day (oral)
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See also Vitamin D Life – very little consensus
- Recurrence of breast cancer not associated with vitamin D levels – Jan 2011
- All items in Breast Cancer and Vitamin D
- Breast Cancer recurred more when less than 20 ng of vitamin D – Oct 2010
- Breast cancer reduced by 10 percent when vitamin D levels exceeded 27 ng
- Meta-analysis not find low vitamin D years before breast cancer – Aug 2010
- Meta-analysis confirmed that vitamin D and calcium prevents breast cancer – June 2010
- Breast cancer reduced by 45 percent for women with the most vitamin D – July 2010
- Breast cancer association with low vitamin D suggested by Meta-analysis -April 2010
- Need lots of UV AND vitamin D to reduce risk of breast cancer – Jan 2011
- Breast cancer may result from poor interaction with vitamin D – Sept 2010
- China has documented that less UV results in more cancer – June 2010 - not just Breast Cancer