Associations between abnormal vitamin D metabolism pathway function and non-small cell lung cancer.
Oncol Lett. 2017 Dec;14(6):7538-7544. doi: 10.3892/ol.2017.7162. Epub 2017 Oct 10.
Ge N1, Chu XM1, Xuan YP1, Ren DQ2, Wang Y1, Ma K1, Gao HJ1, Jiao WJ1.
Genetics category listing contains the following
see also
384 articles in Vitamin D Receptor 140 articles in Vitamin D Binding Protein = GC 35 articles in CYP27B1 - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Snapshot of the literature by Vitamin D Life as of early 2019
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of Vitamin D Life took action with clues #3&4
Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 is an example of massive gene changes in another Cancer
shaded text and numbers in the chart were added by Vitamin D Life
Note: this study did not consider the Vitamin D Receptor gene- Lung cancer – reduced deaths if have a good vitamin D gene (CYP27B1) – Feb 2015 has the following chart
- Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011 has the following chart
 Download the PDF from Vitamin D Life
Genes in study are marked with dashed ovals (invisible to Vitamin D tests)
24A1 Active vitamin D is pissed away more than usual
27B1 Kidney does not activate as much Vitamin D
Lung cancer is a type of malignant tumor derived from the respiratory system, which is the leading cause of cancer-associated mortality worldwide, of which ~80% of cases are attributable to non-small cell lung cancer (NSCLC). A previous study demonstrated that 1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3), derived from the vitamin D metabolic pathway contributes an antitumor effect. Aberrant expression of the essential enzyme encoding genes, Cytochrome P450 Family 27 Subfamily A Member 1 (CYP27A1), Cytochrome P450 Family 27 Subfamily B Member 1 (CYP27B1), and Cytochrome P450 Family 24 Subfamily A Member 1 (CYP24A1) may be associated with lung cancer. However, a lack of evidence exists concerning the association between CYP27A1, CYP27B1, CYP24A1 expression and NSCLC. The aim of the present study was to investigate the functions of CYP27A1, CYP27B1 and CYP24A1 expression in NSCLC. Lung cancer tissue and para-carcinoma control tissue were collected from patients with NSCLC. Reverse transcription-quantitative polymerase chain reaction was applied to analyze CYP27A1, CYP27B1 and CYP24A1 mRNA expression in lung cancer tissues. An association analysis was performed between the aforementioned metabolic enzymes and patients with NSCLC age, gender, tumor node metastasis (TNM) stage, pathological type, differentiation and prognosis. CYP27B1 and CYP24A1 mRNA were upregulated in NSCLC compared with controls (P<0.05). However, no significant differences in CYP27A1 expression were observed between NSCLC and control. In addition, CYP24A1 expression was not associated with age, sex, smoking or TNM stage, but was associated with pathological type, differentiation and prognosis (P<0.05). CYP27B1 expression was significantly associated with TNM stage, differentiation, and prognosis, but not age, sex, smoking or pathological type. In conclusion, CYP27B1 and CYP24A1 may be considered as independent prognostic factors of NSCLC and may be novel therapeutic targets to assist clinical diagnosis, treatment and prognosis of the disease.
PMID: 29250167 PMCID: PMC5727627 DOI: 10.3892/ol.2017.7162
Live longer with lung cancer if have good vitamin D genes (or perhaps lots of vitamin D) – Dec 20171559 visitors, last modified 17 Jun, 2018, This page is in the following categories (# of items in each category)Genetics266 Cancer - Lung 49 Attached files
ID Name Comment Uploaded Size Downloads 9960 CYP27B1.jpg admin 17 Jun, 2018 18:50 23.03 Kb 232 9959 CYP24A1.jpg admin 17 Jun, 2018 18:50 22.93 Kb 200 9958 Gene red blue.jpg admin 17 Jun, 2018 18:49 66.08 Kb 216 9957 Lung Cancer.pdf PDF 2018 admin 17 Jun, 2018 18:49 1.06 Mb 344 See any problem with this page? Report it (FINALLY WORKS)