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- Real-world data on vitamin D supplementation and its impacts in systemic lupus erythematosus: Cross-sectional analysis of a lupus registry of nationwide institutions (LUNA)
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7 studies in both categories Lupus and Intervention - Vitamin D Life
6 studies in both categories Lupus and Vitamin D Receptor Real-world data on vitamin D supplementation and its impacts in systemic lupus erythematosus: Cross-sectional analysis of a lupus registry of nationwide institutions (LUNA)
PLoS One. 2022 Jun 29;17(6):e0270569. doi: 10.1371/journal.pone.0270569
Keigo Hayashi 1, Ken-Ei Sada 1 2, Yosuke Asano 1, Yu Katayama 1, Keiji Ohashi 1, Michiko Morishita 1, Yoshia Miyawaki 1, Haruki Watanabe 1, Takayuki Katsuyama 1, Mariko Narazaki 1, Yoshinori Matsumoto 1, Nobuyuki Yajima 3 4, Ryusuke Yoshimi 5, Yasuhiro Shimojima 6, Shigeru Ohno 7, Hiroshi Kajiyama 8, Kunihiro Ichinose 9, Shuzo Sato 10, Michio Fujiwara 11, Jun Wada 1Why did they bother to write the article when they did not know how much Vitamin D was given?
Background: Although vitamin D concentration is reportedly associated with the pathogenesis and pathology of systemic lupus erythematosus (SLE), benefits of vitamin D supplementation in SLE patients have not been elucidated, to our knowledge. We investigated the clinical impacts of vitamin D supplementation in SLE.
Methods: A cross-sectional analysis was performed using data from a lupus registry of nationwide institutions. We evaluated vitamin D supplementation status associated with disease-related Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) as a parameter of long-term disease activity control.
Results: Of the enrolled 870 patients (mean age: 45 years, mean disease duration: 153 months), 426 (49%) received vitamin D supplementation. Patients with vitamin D supplementation were younger (43.2 vs 47.5 years, P < 0.0001), received higher doses of prednisolone (7.6 vs 6.8 mg/day, P = 0.002), and showed higher estimated glomerular filtration rates (79.3 vs 75.3 mL/min/1.73m2, P = 0.02) than those without supplementation. Disease-related SDI (0.73 ± 1.12 vs 0.73 ± 1.10, P = 0.75), total SDI, and SLE Disease Activity Index (SLEDAI) did not significantly differ between patients receiving and not receiving vitamin D supplementation. Even after excluding 136 patients who were highly recommended vitamin D supplementation (with age ≥ 75 years, history of bone fracture or avascular necrosis, denosumab use, and end-stage renal failure), disease-related SDI, total SDI, and SLEDAI did not significantly differ between the two groups.
Conclusions: Even with a possible Vitamin D deficiency and a high risk of bone fractures in SLE patients, only half of our cohort received its supplementation. The effect of vitamin D supplementation for disease activity control was not observed.
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74 items in LUPUS category Some of the studies in Vitamin D Life
- Every aspect of Lupus is associated with low viramin D – Oct 2021
- It is time to routinely give vitamin D to Lupus patients – Dec 2016
- 93 pcnt of these Lupus patients supplemented with Vitamin D - Nov 2020
- Lupus patients are 5 X more likely to have low vitamin D – many meta-analyses
- Lupus fought by Vitamin D in all trials longer than 12 weeks - review Sept 2017
196 items Rheumatoid Arthritis: 115 items Autoimmune disease, mainly in 50 per 100,000 women, no cure, many parts of body Wikipedia
Vitamin D Life -
7 studies in both categories Lupus and Intervention This list is automatically updated
- Lupus: 60,000 IU Vitamin D monthly got to only 34 ng, not enough to help – RCT Jan 2023
- Lupus reduced when half of participants got to 38 ng of Vitamin D (not statistically significant) – RCT Jan 2017
- Juvenile Lupus fatigue reduced by vitamin D ( 50,000 IU weekly for 6 months) – RCT May 2015
- Musculoskeletal pain reduced with 4,000 IU of vitamin D – RCT April 2015
- Lupus reduced with vitamin D intervention – Feb 2014
- Lupus flareups cut in half by just 2,000 IU of vitamin D – RCT Dec 2012
- Lupus flares totally eliminated by loading dose then 100000 IU of vitamin D each month – Oct 2012
Vitamin D Life
6 studies in both categories Lupus and Vitamin D Receptor This list is automatically updated
- Lupus 3.8 X more likely if a poor Vitamin D Receptor – May 2019
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Lupus in children 2.6 X more likely if they had poor Vitamin D Receptor – Jan 2017
- Lupus associated with both low vitamin D and Vitamin D receptor problems – April 2016
Lupus not helped by an unknown amount of Vitamin D – June 2022(Cached) Printer Friendly Follow this page for updates1109 visitors, last modified 01 Jul, 2022, This page is in the following categories (# of items in each category)Attached files
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