Disassociation of Vitamin D's Calcemic Activity and non-calcemic Genomic Activity and Individual Responsiveness: A Randomized controlled Double-Blind clinical Trial
Scientific RepoRtS | (2019) 9:17685 | https://doi.org/10.1038/s41598-019-53864-1
Arash Shirvani ,tyler Arek Kalajian, Anjeli Song & Michael F. Holick*
Randomized Controlled Trial lasting 24 weeks with 30 healthy adults of mixed race and sex
- 291 genes improved expression by 2000 IU of vitamin D – RCT March 2013
- Previous study by same authors
See also Vitamin D Life
- Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018
- Benefits of Vitamin D often limited by genes
- Gene activation by high dose vitamin D - both quick and long term - April 2015
Genes and Pregnancy
- Vitamin D genes and pregnancy – 7th study - Sept 2017
- 430 genes changed when 3,800 IU Vitamin D added in late second trimester – RCT May 2018
- 5839 genes changed during pregnancy (many genes were related to Vitamin D) – Oct 2016
Genes and MS
- Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
- 98 pcnt of genes that Vitamin D activates to reduce MS are also activated by Interferon -May 2013
Future Vitamin D gene studies could examine the gene changes:
- to the 35+ genes associated with Vitamin D
- Vitamin D Receptor, Vitamin D Binding Protein, etc.
- If also use any of the 12+ Vitamin D Receptor activators - such as Resveratrol
- Associated with the immune system
- In tissues rather than just the blood
- Gut genes
- If start RCT with low levels of vitamin D
- If use infrequent dosing (non-daily)
- Many studies have found better treatment when Vitamin D is given less frequently
- Due to genes?
- If use UVB instead of Vitamin D
- If the person has specific health problems
- If have a poor vitamin D response
- If add co-factors, e.g. Magnesium and Omega-3
- If use a loading dose
Graphic of the study results by Dr. Raimund von Helden
Graphic and web page in German
Title translated from German: Vitamin D commands over 1200 genes - but only at a vitamin D level of 78 ng / ml
Graphics by GRH: 8X more genes changed
Vitamin D Receptor
Vitamin D Receptor category has the following
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
A poor VDR increases the risk of 55 health problems click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
Compensate for poor VDR by increasing one or more:
Increasing | Increases |
1) Vitamin D supplement Sun, Ultraviolet -B | Vitamin D in the blood and thus in the cells |
2) Magnesium | Vitamin D in the blood AND in the cells |
3) Omega-3 | Vitamin D in the cells |
4) Resveratrol | Vitamin D Receptor |
5) Intense exercise | Vitamin D Receptor |
6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
7) Quercetin (flavonoid) | Vitamin D Receptor |
8) Zinc is in the VDR | Vitamin D Receptor |
9) Boron | Vitamin D Receptor ?, etc |
10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
11) Progesterone | Vitamin D Receptor |
12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D in the cells |
13) Sulfroaphone and perhaps sulfur | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR
10+ Vitamin D Receptor studies have overlaps to Health Problems
- VDR & Diabetes
18 studies - VDR & Breathing
21 studies - VDR & Breast Cancer
15 studies - VDR & Cancer - general
15 studies - VDR & Obesity
14 studies - VDR &Multiple Sclerosis
18 studies Vitamin D Binding Protein
MS and Vitamin D Binding Protein:
- Vitamin D genes increase MS relapses in children by 2X – May 2019
- Mendelian proof that low vitamin D (due to 3 genes) increase risk of MS by 20 percent – Nov 2016
- Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015
- Multiple Sclerosis is associated with about 1.5 X more Vitamin D Binding Protein – Jan 2015
- Late-stage MS associated with protein in spinal cord which blocks vitamin D – Jan 2013
TB and Vitamin D Binding Protein:
Breathing and Vitamin D Binding Protein:
- Asthma more closely associated with poor VDBP gene than with poor Vitamin D level – June 2014
- COPD in Asians twice as likely if poor Vitamin D Binding Protein – meta-analysis May 2019
- COPD strongly associated with Vitamin D Binding Protein problems – meta-analysis Aug 2015
- Gene makes COPD 2.6X more likely unless get more vitamin D – meta-analysis Dec 2014
- Vitamin D Binding Protein, And Airflow In COPD - April 2012
- Genetic link found between vitamin D and COPD – June 2010
- How vitamin D helps the lung via vitamin D-binding protein - May 2010
Infant-Child and Vitamin D Binding Protein:
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Decreased response to vitamin D in white children having poor Vitamin D binding gene – Feb 2019
- Ear infections in children 3X more likely if poor vitamin D binding protein – July 2018
- Vitamin D is more bio-available when children are critically ill (less Binding Protein) – Sept 2015
- Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
Pregnancy and Vitamin D Binding Protein:
- During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preeclampsia 11X more likely if poor Vitamin D Binding Protein (South Africa) - Sept 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Fetal Growth poor if Vitamin D-Binding Protein gene poor – Feb 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Preeclampsia changes to Vitamin D Binding Protein reduces Vitamin D in placenta – Dec 2016
- Bio-available Vitamin D is reduced by half during pregnancy – Jan 2017
- Changes during pregnancy of vitamin D (decrease), DBP (2X) and albumin (0.8X) – Oct 2014
 Download the PDF from Vitamin D Life
The aims of this randomized controlled double-blind clinical trial were to assess the impact of vitamin D supplementation on calcium metabolism and non-calcemic broad gene expression by relating them to the individual's responsiveness to varying doses of vitamin D3. thirty healthy adults were randomized to receive 600, 4,000 or 10,000 IU/d of vitamin D3 for 6 months. Circulating parathyroid hormone (PTH), 25(OH)D, calcium and peripheral white blood cells broad gene expression were evaluated. We observed a dose-dependent increase in 25(OH)D concentrations, decreased PTH and no change in serum calcium. A plateau in PTH levels was achieved at 16 weeks in the 4000 and 10,000 IU/d groups. There was a dose-dependent 25(OH)D alteration in broad gene expression with 162, 320 and 1289 genes up- or down-regulated in their white blood cells, respectively. our results clearly indicated that there is an individual's responsiveness on broad gene expression to varying doses of vitamin D3. Vitamin D3 supplementation at 10,000 IU/d produced genomic alterations several fold higher than 4,000 IU/d even without further changes in PTH levels. Our findings may help explain why there are some inconsistency in the results of different vitamin D's clinical trials.
More genes changed with higher doses of Vitamin D (suggest future gene studies) - RCT Dec 2019855 visitors, last modified 16 Nov, 2020, This page is in the following categories (# of items in each category)Genetics266 Attached files
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