Vitamin D Receptor Genetic Polymorphisms and the Risk of Multiple Sclerosis: A Systematic Review and Meta-Analysis
Steroids, 108615 2020 Feb 22, DOI: 10.1016/j.steroids.2020.108615
Asadollah Mohammadi 1, Asaad Azarnezhad 1, Hashem Khanbabaei 2, Esmael Izadpanah 3, Rasoul Abdollahzadeh 4, George E Barreto 5, Amirhossein Sahebkar 6
The articles in both of the categories MS and Vitamin D Receptor are:
- Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020
- Risk of Multiple Sclerosis varies with the Vitamin D Receptor – meta-analysis Dec 2019
- Multiple Sclerosis and Vitamin D Receptor super enhancers – March 2019
- Vitamin D genes increase MS relapses in children by 2X – May 2019
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
- Multiple sclerosis (relapsing-remitting) increases activation of Vitamin D Receptor by 6.6 X – March 2017
- Multiple Sclerosis is more likely if poor Vitamin D Receptor (4X Mexico, 3X Iran)– Feb 2017
- Multiple Sclerosis much more likely if poor Vitamin D Receptor – several studies
- Multiple Sclerosis and the Vitamin D Receptor – meta-analysis July 2014
- Overview MS and vitamin D
- Multiple Sclerosis treated when use high doses of vitamin D – meta-analysis May 2018
- Multiple Sclerosis: number needed to treat with vitamin D may be as low as 1.3 – Meta-analysis Oct 2013
- Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
- Multiple Sclerosis relapses cut in half by 100,000 IU of Vitamin D every 2 weeks– RCT 2019
UV and Sunshine reduces MS risk
- Multiple Sclerosis 2X more likely if low winter UV – June 2018
- Multiple Sclerosis half as likely if get plenty of sunshine (not a news item) – March 2018
Other things also help
- Multiple Sclerosis treated by 50,000 IU Vitamin D bi-weekly plus Omega-3 – RCT July 2018
- Multiple Sclerosis 40 percent less likely if consume tinned fish (Vitamin D and Omega-3) – Sept 2019
- Resveratrol treats Multiple Sclerosis and other autoimmune diseases – many studies
- Not a single case of multiple sclerosis in 15,000,000 people (plant-based diets)
High Dose Vitamin D and cofactors
- The use of high dose Vitamin D (Coimbra Protocol) for multiple sclerosis in Germany – 2019
- Successful high dose vitamin D (Coimbra Protocol) should be evaluated – June 2019
- Comparing High-dose vitamin D therapies MS and other health problems
Number of MS studies which are also in other categories
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20 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells 11 studies in Vitamin D Receptor - gene which restricts D from getting to the cells 5 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells 19 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS Download the PDF from Sci-Hub via Vitamin D Life
There are conflicting results regarding the exact effect of the vitamin D receptor (VDR) gene polymorphisms on the susceptibility to multiple sclerosis (MS). Therefore, we aimed to investigate the impact of four major studied VDR gene polymorphisms consisting of ApaI, BsmI, FokI, and TaqI on the risk of MS in the Iranian population. A literature search was performed in various databases to find case-control studies evaluating the association between VDR gene polymorphisms and MS risk in Iran. Data were extracted and odds ratios (OR) with 95% confidence intervals (CI) were calculated. Subgroup analyze was performed to detect potential sources of heterogeneity. A total of 1206 cases and 1402 controls in nine case-control studies were included. ApaI was the only variant which showed statistically significant relation in
- allelic (OR=0.54 (95% CI: 0.37-0.79); P=0.00),
- homozygote (OR=3.48 (95% CI: 1.7-6.9); P=0.00),
- dominant (OR=0.56 (95% CI: 0.3-0.79); P=0.01), and
- recessive (OR=0.35 (95% CI: 0.18-0.66); P=0.00) models.
The TaqI polymorphism showed a significant negative association with MS only in the homozygote model
- (OR= 0.28 (95% CI: 0.08-0.9); P=0.04).
The BsmI polymorphism also showed significant relation in
- allelic (OR= 0.69 (95% CI: 0.51-0.94); P=0.01),
- homozygote (OR= 0.46 (95% CI: 0.25-0.86); P=0.01), and
- recessive OR= 0.56 (95% CI: 0.39-0.8); P=0.00) models after performing sensitivity analysis.
FokI polymorphism showed no significant association with MS risk. ApaI and TaqI TT genotype were found contributing to MS susceptibility and BsmI and FokI showed no relation with MS susceptibility in the Iranian population.
Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020Printer Friendly PDF this page! Follow this page for updates526 visitors, last modified 26 Feb, 2020, This page is in the following categories (# of items in each category)