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Parkinson’s disease: Review of low-dose vitamin D RCTs found small benefit – Sept 2023


Vitamin D in Parkinson’s disease: A systematic review of randomized controlled trials.

Clinical Nutrition Open Science Available online 28 September 2023 https://doi.org/10.1016/j.nutos.2023.09.005
Paraskevi Detopoulou 1 3, Gavriela Voulgaridou 2, Alexandra Saridaki 1 3, Ioanna Pylarinou 3, Elissaios- Minos Argyris 1, Vasilios Dedes 3, Constantinos Giaginis 4, Georgios I. Panoutsopoulos 3, Sousana K. Papadopoulou 2

In recent years, neurodegenerative diseases are a leading cause of morbidity and disability worldwide, with Parkinson's disease (PD) being the most prevalent. Although diet and vitamin status play a crucial role in PD, the results of vitamin D supplementation are scarce and contradictory. Therefore, the present systematic work reviewed the available randomized controlled trials (RCTs) regarding the role of vitamin D supplementation in patients with PD in the Pubmed, Scopus and Cochrane databases and in grey literature. Four RCTs including 321 patients with PD were identified. Various doses of vitamin D were administered (1,000- 10,000 IU/d) and different exposure outcomes were assessed. One study reported beneficial effects of vitamin D on the Hoehn and Yahr scale (HY) and two studies reported null effects on the Unified Parkinson's Disease Rating Scale (UPDRS). Regarding functional tests, heterogeneous results in the timed-up and go (TUG) test were observed in two studies. One study conducted minute walking tests at 6 and 10 minutes and found an improvement only in the 6MWT. In conclusion, a very small number of RCTs have assessed the effects of vitamin D supplementation on PD. Some isolated beneficial effects of vitamin D were reported on functional scales and tests but more studies are needed to draw safe conclusions regarding its supplementation in PD.
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Vitamin D Life - Overview Parkinson's and Vitamin D contains :


VitaminDwiki – Comparing High-dose vitamin D therapies contains:

Dr. Coimbra
books 2018 2016
Dr. Somerville
Optimal Dose
Dr. GominakMr. BatchellerDr. Bredsen
End of Alz.
Health problem Multiple Sclerosis
autoimmune, PD
sleep, flu, pain,
obesity, etc.
SleepCluster, Migraine
Headaches
Alzheimer's
Park. being added
Number of people
(2019)
30,000
by 2022
5,000 5,000 8,000
(2023)
>1,000 ?
Vitamin D targetPTH is target
typ: 150ng of D
100-140+ ng 60-80 ngPTH is target
typ: 80 ng of D
40-60 ng
Vitamin D daily dose
(K = 1,000 IU)
20K - 200K
1,000 IU/kg
30K 2K + monthly
test increasing
dose until goal
4K - 40K
110 IU/kg
?
Omega-3 * O-3 O-3- - - O-3O-3
Magnesium *MgMg - - - Mg (400 mg) -
Vitamin K2 K2 (no longer?) K2 - - -K2 -
Vitamin B...B2, B9, B12 B3 B50-B100
3 months
B50B12
Zinc *Zn - - - Zn -
Boron *? B - - - B -
Calcium
Minimize rock-based Ca
Decrease Ca - - -Ca-
Vitamin A
avoid extremes
avoid A avoid A - - - A-
OtherCholine
Selenium
Co-Q 10
- - - Co-Q 10-
Loading dose
Days instead of months
- - - - - - - - - Loading
"Cluster Balm"
-

Attached files

ID Name Comment Uploaded Size Downloads
20198 PD review of RCT_CompressPdf.pdf admin 07 Oct, 2023 325.29 Kb 40