Role of vitamin D supplementation for primary prevention of cancer: Meta-analysis of randomized controlled trials.
abstract ASCO Poster June 3, 2019
Published study on Vitamin D Life Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019
Unfortunately abstract does not state how much vitamin D was given in RCTs
The following rarely cover the specific Cancers
Items in both categories Cancer and Intervention are listed here:
- Prostate Cancer treatment (Vitamin D, Omega-3, Tumeric) RCT ending Dec 2018
- Cancer risk reduced 65 percent by vitamin D levels greater than 40 nanograms – April 2016
- Mayo clinic starting Cancer RCT using grossly inadequate 2,000 IU of vitamin D – Sept 2013
- Not enough women willing to stop taking vitamin D to permit breast cancer clinical trial – June 2012
- Active form of vitamin D appears to help prevent and treat some cancers – Feb 2011
Items in both categories Cancer and Metanalysis are listed here:
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Vitamin D fights 13 cancers – review of 35 meta-analyses – Oct 2020
- People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019
- Non-Hodgkin Lymphoma 20 percent more likely if low UV – meta-analysis April 2019
- Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019
- Cancer not treated by Vitamin D when ignore dose size, type, and length of trial – meta-analysis April 2018
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer risk weakly associated with vitamin D-binding protein – meta-analysis Sept 2015
- Obesity causes 20 percent of all cancer, low vitamin D may be the connection – meta-analysis - Sept 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
- Death of women from cancer 24 percent less likely if 20 ng more vitamin D – meta-analysis Sept 2013
- Probably need more than 1000 IU of vitamin D to prevent cancer – meta-analysis Aug 2013
- Vitamin D has a complex relationship with Cancer – meta-analysis July 2011
- Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent– May 2010
Items in both categories Cancer and Mortality are listed here:
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cancer is leading cause of death - Vitamin D and Receptor activators help
- Vitamin D Supplements Reduce Cancer Mortality – Greger Sept 2019
- Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014
- People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019
- Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019
- Cancer incidence not reduced by 1100 IU of vitamin D (proven again) but mortality decreased – June 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Death of women from cancer 24 percent less likely if 20 ng more vitamin D – meta-analysis Sept 2013
- Vitamin D protects against many types of health problems – review May 2013
- Vitamin D and Cancer Mortality – review Jan 2013
- More US deaths due to cancer than heart if dark skinned – Sept 2012
- Lack of solar UVB in US is associated with some Cancers - 2006
- Mortality and Cancer varies with latitude in France too – 2010
- Solar radiation, vitamin D and cancer incidence and mortality in Norway
Blurry image of presented poster
Varun Samji, Tarek Haykal, Yazan Zayed, Inderdeep Gakhal, Vijay Veerapaneni, Michelle Obeid, Babikir Kheiri, Sunil Badami, Ghassan Bachuwa, Rizwan Danish; Hurley Medical Center/Michigan State University, Flint, MI; Genesee Cancer and Blood Disease, Flint, MI
In the United States cancer is the second leading cause of mortality, as such, primary prevention of cancer is a major public health concern. Vitamin D supplementation has been studied as a primary prevention method for multiple diseases including cardiovascular disease, osteoporosis, diabetes mellitus and cancer. The role of aspirin as primary prevention of cancer is still controversial. With fast emergence of large randomized controlled trials (RCTs) in that regards, we aimed to evaluate the efficacy of Vitamin D supplementation as primary prophylaxis for cancer.
Methods:
A comprehensive electronic database search was conducted for all RCTs where comparison of Vitamin D supplementation versus placebo for the prevention of any type of disease with at least 3 years of Vitamin D supplementation was used and where cancer incidence or mortality was reported. The primary outcome was cancer-related mortality and cancer incidence. We calculated risk ratios (RRs) and 95% confidence intervals (CIs) using a random-effects model at the longest follow-up.
Results:
We included 10 RCTs with 79,055 total patients, mean age of 68.07 years, a female percentage of 78.02% and a minimum follow-up of 4 years and more. Vitamin D was associated with significant reduction of cancer-related mortality compared with placebo (RR 0.87; 95% CI: 0.79-0.96; P = 0.05: I2= 0%). Compared with placebo, Vitamin D was not associated with significant reduction of cancer incidence (RR: 0.96; 95% CI: 0.86-1.07; P = 0.46; I2= 31%).
Conclusions:
Our study highlights that the use of Vitamin D supplementation for primary prevention of cancer is important as it does decrease cancer-related mortality once cancer is diagnosed, however it has no role or effect on cancer incidence