Immune function and serum vitamin D in shelter dogs: A case-control study
Vet J. 2020 Jul;261:105477. doi: 10.1016/j.tvjl.2020.105477
L N Allison 1, J A Jaffey 2, N Bradley-Siemens 3, Z Tao 1, M Thompson 4, R C Backus 5
Immunity category starts with
see also
Virus category listing hasOverview Influenza and vitamin D
Search for treg OR "t-cell" in Vitamin D Life 1440 items as of Jan 2020
Search VitaminDWik for INFECTION in title 50 items as of Aug 2019
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Vitamin D Every Day to Keep the Infection Away 2015 file
shows increasing publications on vitamin D and Infection
Overview Veterinary and vitamin D has the following
Veterinary category has 130 itemsVets give 3X vitamin D than the US govt recommends for animal OR humans
Farm Vets are paid when their "patients" are healthy,
vs doctors who are paid only when "patients" become sick
A few Vet items in Vitamin D Life
- Vitamin D types and amounts vary widely between humans and animals – Sept 2020
- Is HyD (25(OH)D) a better form of vitamin D for some animals and maybe humans with liver problems
- Rickets increasing in dogs
- Hens with Vitamin D were better in at least 5 ways – RCT Aug 2018
Cows are routinely given 30 IU per kilogram (which would be 10,000 IU for a 150 lb person)
Same information is available on Cattle need 66 IU of vitamin D per pound
The US RDA of vitamin D for cows is 13 IU per kilogram (which would be 4,300 IU for a 150 lb 'cow')
Virtually all US farmers who raise livestock use feed which is supplemented with vitamin D
Merick Vet Manual supplement if not have UV or sunlight
Parrot-like birds are given 600 IU per pound of feed
The cow experts probably base their ideas on
- what is needed,
- what actually works,
- what is cost effective (vitamin D for a cow costs about $1/year), and
- what does not have ANY long-term bad side-affects
Vet-grade Vitamin D: $50 million for the entire US population for a year.
Cow owners use really low cost vitamin D
Vitamin D costs the owner $1/cow for an entire year for a dose rate which is effectively 10,000 IU for a normal weight human.
Assuming that you want to give say 7,000 IU of vitamin D to every person in the US
And since a person weighs about 1/5 that of a cow, 7,000 IU vitamin D would be about 16 cents per year (vet grade)
Thus the cost of vet-grade vitamin D for the entire US population would be approximately
311 million * 16 cents = $50 million
Download the PDF from sci-hub via Vitamin D Life
This study sought to establish a baseline understanding of immune function and its association with serum vitamin D in shelter dogs. Ten apparently healthy shelter dogs housed in the Arizona Humane Society for ≥7 days and 10 apparently healthy, age, breed, and sex-matched control dogs were included. Serum 25-hydroxyvitamin D (25[OH]D), the major circulating vitamin D metabolite, was measured using high performance liquid chromatography. Whole blood samples were stimulated with lipopolysaccharide (LPS), lipoteichoic acid, or phosphate buffer solution, and tumor necrosis factor (TNF)-ɑ, interleukin (IL)-6, and IL-10 were measured using a canine-specific multiplex bead-based assay. Phagocytosis of opsonized-Escherichia coli and E. coli-induced oxidative burst were evaluated with flow cytometry. Shelter dogs had decreased percentages of granulocytes and monocytes (GM) that had phagocytized opsonized-E coli (P = 0.019) and performed E. coli-induced oxidative burst (P = 0.011). There were no significant differences in TNF-α, IL-6, IL-10, or 25(OH)D concentrations between shelter and control dogs. Serum 25(OH)D concentrations had a weak positive association with the intensity of GM E. coli-induced oxidative burst (r2 = 0.23, P = 0.03). There was a moderate inverse association between serum 25(OH)D concentration and LPS-stimulated TNF-ɑ production in shelter dogs (r2 = 0.40, P = 0.04). These results demonstrate immune dysregulation in vitro in shelter dogs housed for ≥7 days when compared to age, breed, and sex-matched control dogs.
While serum 25(OH)D concentrations did not differ between shelter and control dogs, significant associations between 25(OH)D concentration and immune function parameters in vitro were identified.
Poor immune system associated with low Vitamin D (dogs in this case) – June 2020 280 visitors, last modified 08 Aug, 2020,
(Cached) Printer Friendly PDF this page! Follow this page for updates This page is in the following categories (# of items in each category)
Vets give 3X vitamin D than the US govt recommends for animal OR humans
Farm Vets are paid when their "patients" are healthy,
vs doctors who are paid only when "patients" become sick
A few Vet items in Vitamin D Life
- Vitamin D types and amounts vary widely between humans and animals – Sept 2020
- Is HyD (25(OH)D) a better form of vitamin D for some animals and maybe humans with liver problems
- Rickets increasing in dogs
- Hens with Vitamin D were better in at least 5 ways – RCT Aug 2018
Cows are routinely given 30 IU per kilogram (which would be 10,000 IU for a 150 lb person)
Same information is available on Cattle need 66 IU of vitamin D per pound
The US RDA of vitamin D for cows is 13 IU per kilogram (which would be 4,300 IU for a 150 lb 'cow')
Virtually all US farmers who raise livestock use feed which is supplemented with vitamin D
Merick Vet Manual supplement if not have UV or sunlight
Parrot-like birds are given 600 IU per pound of feed
The cow experts probably base their ideas on
- what is needed,
- what actually works,
- what is cost effective (vitamin D for a cow costs about $1/year), and
- what does not have ANY long-term bad side-affects
Vet-grade Vitamin D: $50 million for the entire US population for a year.
Cow owners use really low cost vitamin D
Vitamin D costs the owner $1/cow for an entire year for a dose rate which is effectively 10,000 IU for a normal weight human.
Assuming that you want to give say 7,000 IU of vitamin D to every person in the US
And since a person weighs about 1/5 that of a cow, 7,000 IU vitamin D would be about 16 cents per year (vet grade)
Thus the cost of vet-grade vitamin D for the entire US population would be approximately
311 million * 16 cents = $50 million
Download the PDF from sci-hub via Vitamin D Life
This study sought to establish a baseline understanding of immune function and its association with serum vitamin D in shelter dogs. Ten apparently healthy shelter dogs housed in the Arizona Humane Society for ≥7 days and 10 apparently healthy, age, breed, and sex-matched control dogs were included. Serum 25-hydroxyvitamin D (25[OH]D), the major circulating vitamin D metabolite, was measured using high performance liquid chromatography. Whole blood samples were stimulated with lipopolysaccharide (LPS), lipoteichoic acid, or phosphate buffer solution, and tumor necrosis factor (TNF)-ɑ, interleukin (IL)-6, and IL-10 were measured using a canine-specific multiplex bead-based assay. Phagocytosis of opsonized-Escherichia coli and E. coli-induced oxidative burst were evaluated with flow cytometry. Shelter dogs had decreased percentages of granulocytes and monocytes (GM) that had phagocytized opsonized-E coli (P = 0.019) and performed E. coli-induced oxidative burst (P = 0.011). There were no significant differences in TNF-α, IL-6, IL-10, or 25(OH)D concentrations between shelter and control dogs. Serum 25(OH)D concentrations had a weak positive association with the intensity of GM E. coli-induced oxidative burst (r2 = 0.23, P = 0.03). There was a moderate inverse association between serum 25(OH)D concentration and LPS-stimulated TNF-ɑ production in shelter dogs (r2 = 0.40, P = 0.04). These results demonstrate immune dysregulation in vitro in shelter dogs housed for ≥7 days when compared to age, breed, and sex-matched control dogs.
While serum 25(OH)D concentrations did not differ between shelter and control dogs, significant associations between 25(OH)D concentration and immune function parameters in vitro were identified.
| 280 visitors, last modified 08 Aug, 2020, |