Vitamin D-Binding Protein Polymorphisms, 25-Hydroxyvitamin D, Sunshine and Multiple Sclerosis
Nutrients 2018,10,184; doi:10.3390/nu10020184
Annette Langer-Gould h*, Robyn M. Lucas , Anny H. Xiang , Jun Wu 3, Lie H. Chen 3,
Edlin Gonzales 3, Samantha Haraszti 3,4, Jessica B. Smith 3, Hong Quach and Lisa F. Barcellos 5
- Los Angeles Medical Center, Neurology Department, Southern California Permanente Medical Group, 1505 N Edgemont Street, Los Angeles, CA 90027, USA
- College of Medicine, Biology & Environment, Australian National University, Canberra, ACT 2000, Australia; robyn.lucas at anu.edu.au
- Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA; anny.h.xiang at kp.org (A.H.X.); jun.x.wu at kp.org (J.W.); lie.h.chen at kp.org (L.H.C.); edlin.g.gonzales at kp.org (E.G.); samanthaha at pcom.edu (S.H.); jessica.b.smith at kp.org (J.B.S.)
- Philadelphia College of Osteopathic Medicine, 4000 Presidential Blvd., Apt. 819, Philadelphia, PA 19131, USA
- QB3 Genetic Epidemiology and Genomics Lab, School of Public Health, University of California Berkeley, 209 Hildebrand Hall, Berkeley, CA 94720, USA; hquach at berkeley.ed (H.Q.); lbarcellos at berkeley.edu (L.F.B.)
* Correspondence: annette.m.langer-gould at kp.org; Tel.: +1-(626)-564-3992; Fax: +1-(626)-564-3403
Many MSers increase their vitamin D intake, but rarely as much as is needed to reverse the symptoms
- Increased risk of multiple sclerosis risk in African Americans due to genes – June 2013
- Overview Dark Skin and Vitamin D
- Diabetes (Type 1) 14X more likely in dark skin children with low levels of vitamin D – May 2015
Overview MS and vitamin D starts with the following summary
Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.
Download the PDF from Vitamin D Life
Smaller increase in Vitamin D supplementation by Hispanics and Whites,
but all about 20% if have MS
Blacks have different dominant polymorphisms in the vitamin D-binding protein (DBP) gene that result in higher bioavailable vitamin D than whites. This study tested whether the lack of association between 25-hydroxyvitamin D (25OHD) and multiple sclerosis (MS) risk in blacks and Hispanics is due to differences in these common polymorphisms (rs7041, rs4588). We recruited incident MS cases and controls (blacks 116 cases/131 controls; Hispanics 183/197; whites 247/267) from Kaiser Permanente Southern California. AA is the dominant rs7041 genotype in blacks (70.0%) whereas C is the dominant allele in whites (79.0% AC/CC) and Hispanics (77.1%). Higher 25OHD levels were associated with a lower risk of MS in whites who carried at least one copy of the C allele but not AA carriers. No association was found in Hispanics or blacks regardless of genotype. Higher ultraviolet radiation exposure was associated with a lower risk of MS in blacks (OR = 0.06), Hispanics and whites who carried at least one copy of the C allele but not in others. Racial/ethnic variations in bioavailable vitamin D do not explain the lack of association between 25OHD and MS in blacks and Hispanics. These findings further challenge the biological plausibility of vitamin D deficiency as causal for MS.