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Standard oral vitamin D is not a good way to supplement if have Chronic Kidney Disease – March 2016

Vitamin D Status in Chronic Kidney Disease - UVB Irradiation Is Superior to Oral Supplementation.

Anticancer Res. 2016 Mar;36(3):1397-401.
Krause R1, Roth HJ2, Kaase H3, Stange R4, Holick MF5.

Vitamin D Life Summary

People with poor digestion (CKD, Diabetes, MS, etc) are not able to get much benefit from standard oral vitamin D‰%The study on this page shows if UV is given to those with CKD
Study on this page found with UV that:

  • More vitamin D gets into the bloodstream than with oral
  • Vitamin D receptor improved by 65%
    (which increases the active vitamin D actually getting into the cells)
  • CYP27B1 gene improved by 100%
    (which increases activation of Vitamin D in the Kidney )
  • CYP2R gene improved by 120%

See also Vitamin D Life

Poor guts need different forms of vitamin D

Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)
Slow
Fast nano
Normal
9Nanoemulsion -mucosal
perhaps activates VDR
FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

See also web

Search Google for "Chronic Kidney Disease" and Digestion: 473,000 hits as of March 2017


BACKGROUND:
In chronic kidney disease (CKD) a deficiency of 1,25-dihydroxyvitamin D is common. The aim of this review was to compare vitamin D status after oral supplementation of vitamin D3 to that of serial suberythemal irradiation in end-stage kidney disease (ESKD) patients.

PATIENTS AND METHODS:
Ninety-five patients, with a mean age of 62 (range=35-82) years, were treated with a mean dose of 35,000 (20,000-60,000) IU vitamin D3 per week for a period of 18 months. Fourteen patients, with a mean age of 51 (range=41-57) years, were whole-body UVB irradiated for over 6 months. From 3 hemodialysis patients skin biopsies were performed.

RESULTS:
With oral supplementation 25(OH)D3 increased by 60%. With UV irradiation 25(OH)D3 increased by 400%. Gene expression analysis demonstrated an improvement in the vitamin D receptor (VDR) by 0.65 fold, in 1-alpha-hydroxylase (CYP27B1) by 1.0 fold, and in 25-hydroxylase (CYP2R) by 1.2 fold.

CONCLUSION:
Serial suberythemal UVB irradiation of patients with CKD on dialysis is capable to improve serum 25(OH)D3 and 1,25(OH)2D3 by enhancing the skin's ability to activate vitamin D.

PMID: 26977042

{PDF is behind a publisher paywall

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