Vitamin D Status in Chronic Kidney Disease - UVB Irradiation Is Superior to Oral Supplementation.
Anticancer Res. 2016 Mar;36(3):1397-401.
Krause R1, Roth HJ2, Kaase H3, Stange R4, Holick MF5.
People with poor digestion (CKD, Diabetes, MS, etc) are not able to get much benefit from standard oral vitamin D‰%The study on this page shows if UV is given to those with CKD
Study on this page found with UV that:
- More vitamin D gets into the bloodstream than with oral
- Vitamin D receptor improved by 65%
(which increases the active vitamin D actually getting into the cells) - CYP27B1 gene improved by 100%
(which increases activation of Vitamin D in the Kidney ) - CYP2R gene improved by 120%
See also Vitamin D Life
266 articles in Genetics category - All items in sub category Vitamin D Receptor
384 items - Search Vitamin D Life for Cyp2R1 412 hits Dec 2016
Poor guts need different forms of vitamin D
Guesses of Vitamin D response if poor gut
Bio Form Speed Duration 10 Injection ($$$)
or Calcidiol or CalcitriolD - Slow
C -FastLong 10 Sun/UVB Slow Long 10 Topical
(skin patch/cream, vagina)Slow
Fast nanoNormal 9 Nanoemulsion -mucosal
perhaps activates VDRFast Normal 9? Inhaled (future) Fast Normal 8 Bio-D-Mulsion Forte Normal Normal 6 Water soluble (Bio-Tech) Normal Normal 4 Sublingual/spray
(some goes into gut)Fast Normal 3 Coconut oil based Slow Normal 2 Food (salmon etc.) Slow Normal 2 Olive oil based (majority) Slow Normal 10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 monthsSee also web
Search Google for "Chronic Kidney Disease" and Digestion: 473,000 hits as of March 2017
BACKGROUND:
In chronic kidney disease (CKD) a deficiency of 1,25-dihydroxyvitamin D is common. The aim of this review was to compare vitamin D status after oral supplementation of vitamin D3 to that of serial suberythemal irradiation in end-stage kidney disease (ESKD) patients.PATIENTS AND METHODS:
Ninety-five patients, with a mean age of 62 (range=35-82) years, were treated with a mean dose of 35,000 (20,000-60,000) IU vitamin D3 per week for a period of 18 months. Fourteen patients, with a mean age of 51 (range=41-57) years, were whole-body UVB irradiated for over 6 months. From 3 hemodialysis patients skin biopsies were performed.RESULTS:
With oral supplementation 25(OH)D3 increased by 60%. With UV irradiation 25(OH)D3 increased by 400%. Gene expression analysis demonstrated an improvement in the vitamin D receptor (VDR) by 0.65 fold, in 1-alpha-hydroxylase (CYP27B1) by 1.0 fold, and in 25-hydroxylase (CYP2R) by 1.2 fold.CONCLUSION:
Serial suberythemal UVB irradiation of patients with CKD on dialysis is capable to improve serum 25(OH)D3 and 1,25(OH)2D3 by enhancing the skin's ability to activate vitamin D.PMID: 26977042
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Standard oral vitamin D is not a good way to supplement if have Chronic Kidney Disease – March 20161488 visitors, last modified 12 Apr, 2017, - All items in sub category Vitamin D Receptor