Vitamin D Deficiency and Electrocardiographic Subclinical Myocardial Injury: Results from National Health and Nutrition Examination Survey‐III
Clinical Cardiology, https://doi.org/10.1002/clc.23078
Muhammad Imtiaz Ahmad MBBS Parag Anilkumar Chevli MBBS Yabing Li MD Elsayed Z. Soliman MD, MSc, MS
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
Meta-analyses
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
Omega-3 Helps
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
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Objective
Association of cardiovascular disease (CVD) with non‐traditional risk factors such as vitamin D deficiency has been examined previously. An investigation of the association of vitamin D with subclinical myocardial injury (SC‐MI) based on an electrocardiographic score is a simple, cost‐effective and innovative way to explore this relationship.
Methods
This analysis included 6079 participants (58.3±13.1 years; 54.1% women) without CVD from NHANES III. A multivariable logistic regression model was used to examine the association between vitamin D categories (<20 ng/ml, 20‐29 ng/ml and >30 ng/ml(reference) and cardiac injury score (CIIS).
Results
There was an incremental increase in the prevalence of SC‐MI across vitamin D categories with the highest prevalence in <20 ng/ml, followed by 20‐29 ng/ml and then >30 ng/ml (trend p‐value <.0001). There was a statistically significant association between vitamin D deficiency (<20 ng/ml) and SC‐MI (OR(95%CI): 1.27(1.04‐1.55), p = 0.04). This association was stronger in men than women (OR(95%CI): 1.74(1.32‐2.30) vs. 0.94(0.70‐1.25) respectively; interaction p‐value 0.002).
Conclusions
Vitamin D deficiency is associated with SC‐MI, especially in men. These findings may further highlight the role of non‐traditional risk factors in the development of CVD. The value of vitamin D supplementation in the prevention of myocardial ischemia and injury may warrant investigation.
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