Effect of Vitamin D3 Supplement in Glycemic Control of Pediatrics with Type 1 Diabetes Mellitus and Vitamin D Deficiency
Journal of Clinical and Diagnsotic Research 2015 March V-9 #3 SC05 - SC07
Sakineh Mohammadian, Nasrin Fatahi, Hossein Zaeri, Mohammad Ali Vakili
Correspondence : Dr. Nasrin Fatahi,
Pediatric Resident, Golestan University of Medical Science, Neonatal and Children Health Research Center, Gorgan, Iran. E-mail: nfty3063 at yahoo.com
Background: Glycemic control prevents microvascular complications in patients with type I diabetes mellitus such as retinopathy, nephropathy and neuropathy that influences quality of life. Some studies show the immunomodulatory effect of vitamin D in synthesis and secretion of insulin.
Aims: In this study we evaluate glycemic changes after vitamin D3 supplement in children with type I diabetes mellitus and vitamin D deficiency.
Materials and Methods: In children with type I diabetes mellitus, level of vitamin D and HbA1C was measured. Patients with type I diabetes mellitus who had vitamin D deficiency (25OHD < 50 nmol/lit) treated with 300,000 units of vitamin D3. Calcium supplement (40mg/kg/day) divided in two doses in order to avoid hungry bone was also used. After three months, 25OHD and HbA1C were measured again. Differences, in mean ± SD HbA1C and 25OHD were evaluated before and after the study.
Results: Mean ± SD HbA1C was 9.73±1.85 before the study which was diminished to 8.55±1.91 after vitamin D3 supplement treatment. This decline has a significant difference (p-value < 0.0001). Mean ± SD 25OHD was 17.33±8.97 nmol/lit before the study which is increased to 39.31±14.38 nmol/lit after treatment with vitamin D3 supplement. This increase also has a significant difference (p-value < 0.0001). Vitamin D3 supplement causes the improvement of HbA1C in all groups of glycemic control including HbA1C <7.8, 7.8-9.9, and >9.9. This supplement transfer patients toward better glycemic control for the entire group (p-value < 0.0001).
Conclusion: Vitamin D3 supplement improves HbA1C in pediatrics with type I diabetes mellitus and vitamin D deficiency.
Much more control after "interference"
(2 doses of 150,000 IU of vitamin D + Calcium)
Download the PDF from Vitamin D Life
See also Vitamin D Life
Pages listed in BOTH of the categories Diabetes and Infant/Child
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- Vitamin D2 not help – again ( T1 diabetes– which has been helped by D3) – Jan 2022
- Somewhat less Type 1 Diabetes in Wales recently – perhaps more sun or more vitamin D – March 2021
- Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Poor CYP2R1 gene results in lower vitamin D and 2X increase in T1 Diabetes – Sept 2019
- Milk Consumption Is strongly linked to Type 1 Diabetes – Dr. Greger Nov 2019
- T1 Diabetes treated by Vitamin D and Omega-3 (many other studies agree) Jan 2018
- Children in India – 1 in 7 extremely low Vitamin D, 1 in 10 prediabetic – Sept 2019
- Type 1 diabetes trial having problems getting participants – too many taking Vitamin D or Omega-3 – Aug 2019
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- T1 Diabetes reduction by high Omega-3 and Vitamin D – GRH ongoing observation
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- T1 Diabetes – how it may be prevented and treated by Vitamin D – Dec 2018
- Vitamin D and Omega-3 may treat Type 1 Diabetes – RCT 2024
- Type 1 Diabetes is increasing – decreased vitamin D is one of the many possible reasons – Sept 2018
- Early Type 1 Diabetes May Shorten Women’s Lives by 18 Years - Aug 2018
- Type 1 Diabetes (T1DM) 1.6 X more likely if low vitamin D – meta-analysis Jan 2018
- Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017
- T1 Diabetes associated with many other autoimmune diseases (all related to low vitamin D) – May 2017
- Vitamin D deficiency is associated with prediabetes in obese Swedish children – Oct 2016
- Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017
- Type II Diabetes in children in India increased 4 X in 20 years – Nov 2016
- Type 1 diabetes risk not decreased if add 400 IU vitamin D while pregnant (no surprise) – Dec 2016
- T1 Diabetes in child not prevented by a tiny amount of vitamin D during pregnancy – Nov 2015
- Diabetes (Type 1) increasing 4 percent per year, now 30,000 in the UK - May 2015
- T1 diabetes in children helped with two doses of 150,000 IU of vitamin D and Calcium – March 2015
- Type I diabetes in dark skin children associated with low vitamin D if far from equator – Jan 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- T1 Diabetes associated with low vitamin D - Nov 2014
- Type I Diabetes stopped increasing in Finland after Vitamin D levels were raised – July 2014
- Diabetic children often need more than 7,000 IU of vitamin D – June 2014
- T1 Diabetes 35 percent more likely if 10 degrees further from equator (less vitamin D) – June 2014
- Higher vitamin D at birth associated with less diabetes and obesity 35 years later – Jan 2014
- Type 1 diabetes 3.5X more frequent if low vitamin D - Medscape CME Dec 2012
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Like their diabetic mothers, infants had low vitamin D and were slightly diabetic – May 2012
- Type I diabetes 2X more likely if mother had low vitamin D – Jan 2012
- Overview Diabetes and vitamin D which has these two charts