- Perplexity AI analyzed many studies and concluded that Vitamin D probably helps - May 2025
- Complex Relationship Between Telomere Length and Lifespan - Perplexity AI - May 2025
- The Relationship Between Vitamin D and Telomere/Telomerase: A Comprehensive Review - 2021
- Even the small amount of Vitamin D given by VITAL study (2,000 IU) helped Telomeres - May 2025
- Small amounts of vitamin D taken in first trimester improved Telomeres of offspring - 2021
- Vitamin D Controls Cancer by Regulating Telomere and Telomerase - April 2022
- 50,000 IU vitamin D once a month was not enough to reduce Telomere shortening (D-Health Trial) - Aug 2023
- VitaminDwiki - Longevity and healthspan increased by Vitamin D, Omega-3, Magnesium - many studies
Perplexity AI analyzed many studies and concluded that Vitamin D probably helps - May 2025
Complex Relationship Between Telomere Length and Lifespan - Perplexity AI - May 2025
The Relationship Between Vitamin D and Telomere/Telomerase: A Comprehensive Review - 2021
Review J Frailty Aging . 2021;10(1):2-9. doi: 10.14283/jfa.2020.33.
M Zarei 1, M Zarezadeh, F Hamedi Kalajahi, M H Javanbakht
Telomeres are repetitive nucleotide sequences that together with the associated sheltrin complex protect the ends of chromosomes and maintain genomic stability. Evidences from various organisms suggests that several factors influence telomere length regulation, such as telomere binding proteins, telomere capping proteins, telomerase, and DNA replication enzymes. Recent studies suggest that micronutrients, such as vitamin D, folate and vitamin B12, are involved in telomere biology and cellular aging. In particular, vitamin D is important for a range of vital cellular processes including cellular differentiation, proliferation and apoptosis. As a result of the multiple functions of vitamin D it has been speculated that vitamin D might play a role in telomere biology and genomic stability. In this study, our main goal is investigating the relationship between telomerase enzyme and vitamin D. Findings of this study suggest that higher vitamin D concentrations, which are easily modifiable through nutritional supplementation, are associated with longer LTL, which underscores the potentially beneficial effects of this hormone on aging and age-related diseases. Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. Significant Low levels of telomerase activity create short telomeres, which in turn signal exit from the cell cycle resulting in cell senescence and apoptosis. In follow-up examination, the patients who remained vitamin D deficient tended to have shorter telomeres than those patients whose 25-hydroxyvitamin D levels were depleted. Increasing 25-hydroxyvitamin D levels in patients with SLE may be beneficial in maintaining telomere length and preventing cellular aging. Moreover, anti-telomere antibody levels may be a promising biomarker of SLE status and disease activity.
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Even the small amount of Vitamin D given by VITAL study (2,000 IU) helped Telomeres - May 2025
Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
The American Journal of Clinical Nutrition https://doi.org/10.1016/j.ajcnut.2025.05.003 partial PDF online
Background
Limited studies suggest that vitamin D or omega 3 fatty acids (n–3 FAs) supplementation may be beneficial for telomere maintenance; however, evidence from large randomized clinical trials is lacking. We hypothesized that vitamin D or n–3 FAs supplementation reduce leukocyte telomere length (LTL) attrition over time by leveraging the VITamin D and OmegA-3 TriaL (VITAL) trial.
Methods
VITAL is a large, randomized, double-blind, placebo-controlled trial with a 2 × 2 factorial design of vitamin D3 (2000 IU/d) and marine n–3 FAs (1 g/d) supplements for 5 y among a representative sample of 25,871 US females aged ≥55 and males aged ≥50 y. The VITAL Telomere study (NCT04386577) included 1054 participants who were evaluated in person at the Harvard Clinical and Translational Science Center. LTL was determined by the Absolute Human Telomere Length Quantification Quantitative Polymerase Chain Reaction method at baseline, year 2, and year 4. The prespecified primary outcome measures were changes in LTL between baseline, year 2, and year 4. Analyses of intervention effect used mixed-effects linear regression models.
Results
LTL was measured in a total of 2571 samples from the 1031 participants at baseline, year 2, and year 4. Compared with placebo, vitamin D3 supplementation significantly decreased LTL attrition by 0.14 kilo base pairs (kb) (0.01, 0.27) over 4 y (P = 0.039). Overall trend analysis showed that the vitamin D3 supplementation group had LTLs that were ∼0.035 kb higher per year of follow-up compared with placebo group (0.002, 0.07, P = 0.037). Marine n–3 FAs supplementation had no significant effect on LTL at either year 2 or year 4.
Conclusion
Four years of supplementation with 2000 IU/d vitamin D3 reduced telomere attrition by 140 bp, suggesting that vitamin D3 daily supplementation with or without n–3 FAs might have a role in counteracting telomere erosion or cell senescence.
Small amounts of vitamin D taken in first trimester improved Telomeres of offspring - 2021
Maternal Vitamin D and Newborn Telomere Length
Nutrients 2021, 13(6), 2012; https://doi.org/10.3390/nu13062012
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Vitamin D Controls Cancer by Regulating Telomere and Telomerase - April 2022
Indian Journal of Health Sciences and Care Vol. 9, No. 1, April, 2022, pp- 24-29 DOI: 10.5958/2394-2800.2022.00005.0
Alnakhibi TAO, Researcher, King Abdulaziz University, Saudi Arabia Email id: alnakhibi123 at gmail.com
Deficiency of vitamin D in the body may cause many disorders and diseases including cancer. Vitamin D receptors are one of the most important nuclear receptors responsible for transcription and cellular proliferation and thus affects telomere and telomerase. Telomerase enzymes is responsible for transcription and copies the telomere. The process of telomere copying leads to absence of cell death and thus causes the cellular proliferation of cells within the body. If maintained at normal level, vitamin D regulates and controls the processes of cellular replication and proliferation leading to control and regulation of rate of secretion of telomerase which in turn maintains the appropriate telomere length. Since telomerase is one of the primary factors of cancer spread, telomerase regulation and control can lead to cancer control. Therefore, by maintaining normal vitamin D level in the body DNA can be protected from damage.
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50,000 IU vitamin D once a month was not enough to reduce Telomere shortening (D-Health Trial) - Aug 2023
https://doi.org/10.1007/s12603-023-1948-3