Identification and analysis of 35 genes associated with vitamin D deficiency: A systematic review to identify genetic variants.
J Steroid Biochem Mol Biol. 2019 Oct 30:105516. doi: 10.1016/j.jsbmb.2019.105516
Tiny portion of Figure 4
The story of the Human Body -excellent book by Daniel Lieberman
- People with poor immune systems in the 1800's - 20% died before becoming parents.
- Instead of survival of the fittest (80% survived) we now have survival of the survivors (99% survive)
- But with better hygiene, antibiotics, vaccines, and medical care there are many more people with poor immune systems survive to become parents.
- Low Vitamin D in blood is associated with 69 genes, only 6 of which are reported on - Feb 2020
Many reasons why vitamin D deficiency has become epidemic has a chart updated Oct 2019
Poor responses to UV and Vitamin D were correlated to just 4 poor genes – June 2019
Genetics category listing contains the following
see also
384 articles in Vitamin D Receptor 141 articles in Vitamin D Binding Protein = GC 35 articles in CYP27B1 - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Snapshot of the literature by Vitamin D Life as of early 2019
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of Vitamin D Life took action with clues #3&4
One gene restricts how much Vit. D acually gets to cells (not just reduce blood level)
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor Activation can be increased by any of:
Resveratrol, Omega-3, Magnesium, Zinc, non-daily Vitamin D dosing, etc
Note: The founder of Vitamin D Life uses 10 of the 12 known VDR activatorsVitamin D Receptor and Cancers
Items in both categories Vitamin D Receptor and Cancer - Breast:
- Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019
- After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019
- Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019
- Breast Cancer and Vitamin D review – March 2018
- Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Two chemicals increase the Vitamin D receptor and decrease the growth of breast cancer cells in the lab - March 2018
- Breast Cancer reduces receptor expression and thus block Vitamin D to the cells– July 2017
- Vitamin D receptor as a target for breast cancer therapy (abstract only) – Feb 2017
- Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016
- Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- Vitamin D receptor in breasts and breast cancer vary with race – March 2013
- Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012
- Genes breast cancer and vitamin D receptor - Sept 2010
Items in both categories Vitamin D Receptor and Cancer - Colon:
- Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020
- Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020
- Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019
- Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017
- Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
Items in both categories Vitamin D Receptor and Cancer
- How cancer is fought by Vitamin D (Ovarian this time) – Feb 2020
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Cancer is leading cause of death - Vitamin D and Receptor activators help
- A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Vitamin D receptor is essential for both normal and cancerous cells in the lab – June 2018
- Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Cancer risks and Vitamin D Receptors – association is unclear – 2017
- Vitamin D, Vitamin D Receptor and Cancer – Nov 2016
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR June 2014
- Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013
- Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
Items in both categories Vitamin D Receptor and Cancer - other:
- Blood cell cancer is associated with a 3X worse Vitamin D Receptor – June 2019
- A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019
- Endometriosis, Endometrial Cancer, and poor Vitamin D or Receptor – Aug 2018
- Thyroid Cancer rate has increased 3X in 3 decades, Vitamin D Receptor decreases, Calcium increases – Aug 2017
- Gastric Cancer 2.7 X more likely if poor Vitamin D Receptor (Chinese) – 2015
- 2X more likely to survive a form of esophageal cancer in China if have good vitamin D receptor – Feb 2017
- 2X more Thyroid Cancer malignancy if less than 15 ng of vitamin D – June 2012
- Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010
Items in both categories Vitamin D Receptor and Cancer - Skin:
- Sunlight, Vitamin D and Skin Cancer Book (3rd edition) - Sept 2020
- Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019
- Nonmelanoma Skin Cancer 2X more likely if poor Vitamin D Receptor – Oct 2017
- UVB improvements to Vitamin D receptor appear to improve melanoma survival – Oct 2017
- Skin Cancers, Vitamin D, Vitamin D Receptor and Genes – Jan 2015
- Malignant melanoma may be reduced by skin-activated vitamin D – Nov 2016
- Skin cancer 20 percent more likely with some Vitamin D receptor gene polymorphisms – Oct 2015
- Death from melanoma (without ulcers) greatly decreased if have lots of vitamin D receptors – May 2014
- Melanoma risk 2X to 4X higher if Vitamin D receptor genes had morphed – March 2014
- Vitamin D receptor may suppress skin cancer – Dec 2013
Items in both categories Vitamin D Receptor and Cancer - Prostate:
- Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019
- Prostate surgery outcomes vary with Vitamin D Receptors– May 2017
- Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017
- Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017
- High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016
- 2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013
Items in both categories Vitamin D Receptor and Cancer - Ovarian:
- How cancer is fought by Vitamin D (Ovarian this time) – Feb 2020
- Ovarian Cancer risk reduced if higher vitamin D, more UVB, or better vitamin D receptor – Nov 2018
- Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018
- Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- Ovarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013
 Download the PDF from Vitamin D Life
Sepulveda-Villegas M1, Elizondo-Montemayor L2, Trevino V3.
- 1 Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Bioinformatics Research Group, Ave. Morones Prieto 3000, Colonia Los Doctores, Monterrey, Nuevo León 64710, Mexico.
- 2 Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Bioinformatics Research Group, Ave. Morones Prieto 3000, Colonia Los Doctores, Monterrey, Nuevo León 64710, Mexico; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Center for Research in Clinical Nutrition and Obesity, Ave. Morones Prieto 3000, Colonia Los Doctores, Monterrey, Nuevo León 64710, Mexico; Tecnologico de Monterrey, Cardiovascular and Metabolomics Research Group, Hospital Zambrano Hellion, San Pedro Garza Garcia, P.C., 66278, Mexico.
- 3 Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Bioinformatics Research Group, Ave. Morones Prieto 3000, Colonia Los Doctores, Monterrey, Nuevo León 64710, Mexico. Electronic address: vtrevino at tec.mx.
Vitamin D deficiency is a public health concern associated with, but not limited to, skeletal anomalies, chronic diseases, immune conditions, and cancer, among others. Hypovitaminosis D is mainly associated with environmental and lifestyle factors that affect sunlight exposure. However, genetic factors also influence 25-hydroxyvitamin D (25OHD) serum concentration. Although there is available information of genes with clear biological relevance or markers identified by Genome-Wide Association Studies, an overall view and screening tool to identify known genetic causes of altered serum levels of 25(OH)D is lacking. Moreover, there are no studies including the total genetic evidence associated with abnormal serum concentration of 25(OH)D.
Therefore, we conducted a de-novo systematic literature review to propose a set of genes comprehensive of all genetic variants reported to be associated with deficiency of vitamin D. Abstracts retrieved from PubMed search were organized by gene and curated one-by-one using the PubTerm web tool. The genes identified were classified according to the type of genetic evidence associated with serum 25(OH)D levels and were also compared with the few commonly screened genes related to vitamin D status. This strategy allowed the identification of 35 genes associated with serum 25(OH)D concentrations, 27 (75%) of which are not commercially available and are not, therefore, analyzed in clinical practice for genetic counseling, nor are they sufficiently studied for research purposes. Functional analysis of the genes identified confirmed their role in vitamin D pathways and diseases.
Thus, the list of genes is an important source to understand the genetic determinants of 25(OH)D levels. To further support our findings, we provide a map of the reported functional variants and SNPs not included in ClinVar, minor allelic frequencies, SNP effect sizes, associated diseases, and an integrated overview of the biological role of the genes. In conclusion, we identified a comprehensive candidate list of genes associated with serum 25(OH)D concentrations, most of which are not commercially available, but would prove of importance in clinical practice in screening for patients that should respond to supplementation because of alterations in absorption, patients that would have little benefit because alterations in the downstream metabolism of vitamin D, and to study non-responsiveness to supplementation with vitamin D.
Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019773 visitors, last modified 01 Jul, 2020, This page is in the following categories (# of items in each category)Genetics266 Vitamin D Receptor 384 Vit D Binding Protein 141 CYP27B1 35 Attached files
ID Name Comment Uploaded Size Downloads 13968 Analysis of 35 Genes.pdf PDF 2020 admin 01 Jul, 2020 12:52 4.54 Mb 51 12947 36 gene portion of F4.jpg admin 10 Nov, 2019 02:31 53.89 Kb 135 12946 36 genes.jpg admin 10 Nov, 2019 02:31 170.73 Kb 165 See any problem with this page? Report it (FINALLY WORKS)