Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review
Int. J. Mol. Sci. 2019, 20(3), 628; https://doi.org/10.3390/ijms20030628
Vitamin D Life
Items in both categories Cardiovascular and Vitamin K are listed here:
- Cardiovascular Disease prevented by Vitamin K2-4 when enough is used – RTC review Sept 2020
- Calcium Supplementation is OK provided you also take Vitamin K – Feb 2019
- Vitamin K reduces calcification (reported yet again) – Feb 2019
- Vitamin K (across all dose sizes and types) decrease Vascular Stiffness – meta-analysis - Dec 2018
- Vitamin D and Vitamin K together fight CVD Part 1- Pizzorno
- Vitamin K, Cardiovascular and interactions with Vitamin D and Vitamin A – Pizzorno July 2018
- Mortality associated with Vitamin K insufficiency (PREVEND Study) – Nov 2017
- Intracranial arterial calcification in 85 percent of ischemic strokes (Vitamin K and Vitamin D should help) – Oct 2017
- Decalcify Aortic Valve – 3 year trial with 1 mg of Vitamin K and 5,000 IU of Vitamin D – 2021
- Cardiovascular problems reduced by low dose aspirin and perhaps Omega-3 (also Vit K) – Sept 2017
- Athletes maximal cardiac output increased 12 percent with Vitamin K2 – RCT July 2017
- Fast blood flow 6.8 X more likely if high vitamin D AND high vitamin K – Aug 2017
- Low Vitamin K2 is as risky as smoking for heart disease - Oct 2016
- Cardiovascular death: 9 percent due to hypertension or air pollution, 7 percent: low Vitamin K2 or smoking – Oct 2016
- Decreased need for warfarin after Vitamin D levels optimized – RCT May 2016
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- The health benefits of vitamin K – Oct 2015
- If you must take statins and want to avoid hardening of arteries, take vitamin K2 – RCT May 2015
- Vitamin K2 decreases arterial stiffness (cleans arteries) – RCT Feb 2015
- Hypothesis: Vitamin K will reduce prostate blood vessel problems – Jan 2015
- Increased Vitamin K2 reduces the problems of excess Calcium – Nov 2013
- Cholesterol, Vitamins D3 and K2, heart disease, sulfates, LDL, – Masterjohn Interview Jan 2013
- Soft Bones, Hard Arteries, Vitamin D, Vitamin K2 and antibiotics – Sept 2012
- Vitamin D – vitamin K – bittle bones – hardened arteries – LEF Sept 2010
Items in both categories Caclium and Vitamin K are listed here:
- Lowering Calcium Risk when having High Dose Vitamin D3 – Cawley Dec 2019
- Excess Calcium in critically ill patients taking 10,000 IU of vitamin D (solutions - Vitamin K, or Magnesium, or water) – Oct 2019
- Calcium Supplementation is OK provided you also take Vitamin K – Feb 2019
- Calcium supplements go to muscle, not bone, unless have enough Vitamin K – Feb 2019
- Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
- Vitamin D Cofactors in a nutshell
- Vascular calcification greatly reduced by 1000 ug of Vitamin K2 MK-7 – Dec 2013
- Increased Vitamin K2 reduces the problems of excess Calcium – Nov 2013
- Review of Micronutrients such as vitamin D for women and childhood – Aug 2013
- Healthy bones need Ca, Silicon, Vitamins B, C, D, and K – Dec 2012
- Interview of Vitamin K2 and Calcium Paradox author by Dr. Mercola – Dec 2012
- Vitamin K2 and the Calcium Paradox – 2012 book
- Low cost cofactors for vitamin D
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Stefanos Roumeliotis 1, Evangelia Dounousi 2, Theodoros Eleftheriadis 1 and Vassilios Liakopoulos 1,*
- 1 Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
- 2 Department of Nephrology, Medical School, University of Ioannina, 45110 Ioannina, Greece
Matrix Gla Protein (MGP), a small Gla vitamin K-dependent protein, is the most powerful natural occurring inhibitor of calcification in the human body. To become biologically active, MGP must undergo vitamin K-dependent carboxylation and phosphorylation. Vitamin K deficiency leads to the inactive uncarboxylated, dephosphorylated form of MGP (dpucMGP). We aimed to review the existing data on the association between circulating dpucMGP and vascular calcification, renal function, mortality, and cardiovascular disease in distinct populations. Moreover, the association between vitamin K supplementation and serum levels of dpucMGP was also reviewed.