Vitamin D supplementation in pregnancy and lactation to promote infant growth
N Engl J Med. 2018 Aug 9 : 10.1056/NEJMoa1800927.
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- Intervention - non daily category listing has
194 items along with related searches - Take vitamin D3 daily or weekly shows how large dosing might get more into cells
Notional chart for Vitamin D supplementation for levels < 30 nanograms
Higher gradient (steeper slide) resulting from infrequent dosing results in more Vitamin D getting into the cells.
Note: Virtually all cells of the body can utilize/activate Vitamin D, no liver or kidney needed Download the PDF from Vitamin D Life
Mother
Infant
Daniel E. Roth, M.D., Ph.D., Shaun K. Morris, M.D., Ph.D., Stanley Zlotkin, M.D., Ph.D., Alison D. Gernand, Ph.D., Tahmeed Ahmed, MBBS, Ph.D., Shaila Sharmeen Shanta, MBBS, Eszter Papp, Ph.D., Jill Korsiak, M.Sc., Joy Shi, M.Sc., M. Munirul Islam, MBBS, Ph.D., Ishrat Jahan, MBBS, MPH, Farhana Khanam Keya, MBBS, Andrew R. Willan, Ph.D., Rosanna Weksberg, M.D., Minhazul Mohsin, MBBS, Qazi Sadeq-ur Rahman, M.Sc., Prakesh S. Shah, M.D., Kellie E. Murphy, M.D., Jennifer Stimec, M.D., Lisa G. Pell, Ph.D., Huma Qamar, B.Sc., and Abdullah Al Mahmud, MSS, MMSc.BACKGROUND
Causes of early infant growth restriction remain incompletely understood. Where vitamin D deficiency is common, vitamin D supplementation during pregnancy and lactation may improve fetal-infant growth and other birth outcomes.METHODS
We conducted a randomized, double-blind, placebo-controlled trial of maternal vitamin D supplementation from 17-24 weeks gestation until birth or 6 months postpartum. Participants were randomly allocated to five vitamin D and/or placebo supplementation groups: (A) 0 IU/week, (B) 4200 IU/week, (C) 16800 IU/week, or (D) 28000 IU/week in pregnancy, all with 0 IU/week postpartum; or, (E) 28000 IU/week in prenatal and postpartum periods. The primary outcome was length-for-age z-score at one year of age according to World Health Organization child growth standards.RESULTS
Among 1164 infants assessed at one year of age (90% of 1300 pregnancies), there were no differences across groups in length-for-age z-scores (mean ±standard deviation): A: -0.93 ±1.05, B: -1.11 ±1.12, C: -0.97 ±0.97, D: -1.06 ±1.07, E: -0.94 ±1.00 (p=0.23). Groups were similar with respect to other anthropometric measures, birth outcomes, and morbidity. Vitamin D had dose- dependent effects on maternal and infant serum 25-hydroxyvitamin D and calcium, maternal urinary calcium excretion, and maternal parathyroid hormone concentrations. No clinical adverse events were attributed to the vitamin D intervention.CONCLUSIONS
In a population with widespread prenatal vitamin D deficiency and fetal/infant growth restriction, maternal vitamin D supplementation from mid-pregnancy until birth or 6 months postpartum does not influence fetal or infant growth, and has no beneficial or harmful effects on numerous other birth and infant outcomes.Weekly Vitamin D to mother after birth much better than daily - RCT Aug 20181259 visitors, last modified 09 Feb, 2020, This page is in the following categories (# of items in each category)Pregnancy751 Intervention - non daily 194 Attached files
ID Name Comment Uploaded Size Downloads 11545 Infant.jpg admin 11 Mar, 2019 17:47 36.16 Kb 229 11544 Mother.jpg admin 11 Mar, 2019 17:46 41.73 Kb 248 11543 promote infant growth.pdf PDF 2018 admin 11 Mar, 2019 17:46 892.55 Kb 227 See any problem with this page? Report it (FINALLY WORKS)