450,000 IU of vitamin D over 9 weeks given to 100,000 teenage Iranian girls helped their livers

High dose vitamin D supplementation is associated with an improvement in serum markers of liver function

BioFactors https://doi.org/10.1002/biof.1496

Hamidreza Tavakoli Hossein Rostami Amir Avan Mohammad Bagherniya Gordon A. Ferns

Sayyed Saeid Khayyatzadeh [email protected], Majid Ghayour‐Mobarhan [email protected];

This appears to be the first study of the affects of high-dose vitamin D given to 100,000 Iranian girls. In early 20159.4 ng of Vitamin D+ 9 weeks of 50,000 IU/week ==> 36.4 ngWhat other studies will be published on this massive intervention?Hopefully Iran will continue to give the girls 50,000 IU every two weeks as a maintenance doseHopefully the Vitamin D measurement was done at least 4 days after the last doseIf so, suspect that the Vitamin D levels will have plateaued at about 50 ng at 20 weeksOf the 100,000 girls, 988 were studied to see changes in liver functionDid not notice % of girls with poor livers and % with OK livers From Wikipedia| | || --- | --- || Age group | Number(2011) || 10–14 | 5,671,435 || 15–19 | 6,607,043 |12 million over a 9 year age group in 2011Probably 6 million girls in 9 year age groupPerhaps 4 million in a 6 year age groupSo 100,000 girls = 2.5% of that age groupThus Iran gave 450,000 IU to 2.5% of their teenage girls in 2015---Overview Liver and vitamin D contains the following summary{include}---Note: 300,000 IU is a typical loading dose for teensOverview Loading of vitamin D contains the following {include}---Middle East and Vitamin D contains the following summary{include}

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Limited studies have examined the effects of vitamin D on liver enzymes in patients with liver disease but none has explored its effects in the healthy subjects. The aim of present study was to evaluate the effects of a high dose vitamin D supplementation on measures of liver function. A total of 988 adolescent girls were recruited; all were assessed for liver function tests (LFTs) including alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma‐glutamyl transferase (ϒGT), alkaline phosphatase (ALP), total bilirubin, direct bilirubin, albumin, and total protein before and after supplementation with 50,000 IU cholecalciferol perls. Significant reductions were observed for AST, ALT, direct bilirubin, total bilirubin, LDH, and ϒGT at the end of supplementation, only in the group with abnormal reference value. Serum levels of total protein and albumin were higher at the end of follow up in the group with abnormal value.

No significant change was obtained for LFTs in the group with normal value. Our findings suggest that vitamin D supplementation may improve markers of liver function in adolescents with abnormal LFTs. More randomized controlled trial with longer follow‐up time will be required.