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Synergistic Anticancer Effects of Vitamin D and Plant-Derived Compounds: Molecular Mechanisms, Therapeutic Potential, and Nanotechnology-Enabled Delivery Approaches - March 2026
Int. J. Mol. Sci. 2026, 27, 2507 https://doi.org/10.3390/ijms27052507 Israel
Vitamin D is widely recognized for its pivotal role in the prevention and treatment of various cancers. The active compounds derived from plants have garnered significant attention due to their multi-faceted anticancer properties.
Given the complexity and heterogeneity of cancer, monotherapies often fall short in effectiveness. As a result, combinatorial pharmacological strategies, which utilize multiple drug agents, are increasingly being employed globally.
Notably, emerging evidence highlights the potent synergistic anticancer effects of vitamin D in combination with certain phytochemicals against a variety of cancers. This review explores the cooperative mechanisms through which vitamin D and phytochemicals enhance cancer prevention and therapy. In addition to examining their synergistic effects, this review also discusses recent advancements in nanotechnology-based delivery systems for vitamin D, which hold promise for optimizing its therapeutic potential.
Collectively, these findings underscore the potential of combining vitamin D with phytochemicals and innovative delivery methods as a promising strategy in the fight against cancer, paving the way for more effective, multi-targeted therapeutic approaches.
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