A healthy gut needs Vitamin D and a good vitamin D receptor

Created September 2022

Many gut studies are unaware of the importance of

  • Vitamin D Receptor - which can limit vitamin D getting to cells

  • Vitamin D Receptor activators

  • Gut-friendly forms of Vitamin D

  • Gut biome -which can increase response to vitamin D

Vitamin D and Gut Health

Adv Exp Med Biol. 2022;1390:155-167.doi: 10.1007/978-3-031-11836-4_9   PDF is behind $30 paywall

James C Fleet 1

Vitamin D is a conditionally required nutrient that can either be obtained from skin synthesis following UVB exposure from the diet. Once in the body, it is metabolized to produce the endocrine hormone, 1,25 dihydroxyvitamin D (1,25(OH)2D), that regulates gene expression in target tissues by interacting with a ligand-activated transcription factor, the vitamin D receptor ( VDR ). The first, and most responsive, vitamin D target tissue is the intestine. The classical intestinal role for vitamin D is the control of calcium metabolism through the regulation of intestinal calcium absorption. However, studies clearly show that other functions of the intestine are regulated by the molecular actions of 1,25(OH)2 D that are mediated through the VDR . This includes enhancing gut barrier function, regulation of intestinal stem cells, suppression of colon carcinogenesis, and inhibiting intestinal inflammation. While research demonstrates that there are both classical, calcium-regulating and non-calcium regulating roles for vitamin D in the intestine, the challenge facing biomedical researchers is how to translate these findings in ways that optimize human intestinal health.

Vitamin D Life - studies in both categories Gut and VDR

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Vitamin D Life - Overview Gut and vitamin D contains

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Vitamin D Life - (Overview Gut and vitamin D)) contains gut-friendly information

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Vitamin D Life - studies in both categories Microbiome and Gut

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Vitamin D Life - Vitamin D Receptor activation can be increased in 14 ways

Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise, Butyrate- in Gut   Ginger,   Essential oils, etc  Note: The founder of Vitamin D Life uses 10 of the 14 known VDR activators

PDF References

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