Alzheimer's trials by both Posit Science and Apollo Health
Both Posit Science and Apollo Health have conducted clinical trials focused on interventions for Alzheimer’s disease, particularly in mild cognitive impairment (MCI) or early-stage dementia.
Posit Science Alzheimer’s Trials
- Posit Science, developers of the BrainHQ cognitive training program, have participated in numerous trials, including the large ACTIVE study and the Preventing Alzheimer’s with Cognitive Training (PACT) trial. These studies evaluated the impact of computerized cognitive training on dementia risk, showing that their speed of processing training (SPT) reduced incidence of dementia by up to 29% and improved cognitive function and real-world abilities over several years.[1][2][3][4]
- Recent NIH-funded studies have demonstrated that BrainHQ exercises upregulate acetylcholine production, a neurotransmitter critical for attention and memory, which declines in Alzheimer’s disease. These findings have implications for delaying or reversing cognitive aging.[5][6]
Apollo Health Alzheimer’s Trials
- Apollo Health, associated with Dr. Dale Bredesen, uses a precision medicine approach called ReCODE for Alzheimer’s, addressing root causes like inflammation, toxins, and metabolic issues. Their proof-of-concept trial treated 25 participants with MCI or early dementia using personalized protocols, with cognitive improvements correlated to biomarker changes. This approach has now advanced to randomized controlled trials comparing ReCODE to standard care.[7][8][9][10][11]
- Results from these trials show improved cognitive scores and reduction in brain atrophy rates, with hippocampal volume decline substantially slower than average for Alzheimer’s patients. Over 80% of pilot study participants experienced cognitive improvement.[12][13]
- These precision medicine trials analyze a wide range of biomarkers and hope to further optimize treatments as more data is mined.[7]
Alzheimer’s Clinical Trial Focus Table
| Organization | Trial Focus | Main Findings | Study Design |
|---|---|---|---|
| Posit Science | Computerized cognitive training (BrainHQ, SPT) | Reduced dementia risk, improved cognition, enhanced acetylcholine production | ACTIVE, PACT, NIH-funded imaging and biomarker RCTs[5][1][2][3][4] |
| Apollo Health | Precision medicine (ReCODE) | Cognitive improvements, slower hippocampal atrophy, biomarker enhancement | Proof-of-concept, RCTs comparing ReCODE vs. standard care[7][8][9][13][11] |
Both organizations are contributing important data to non-pharmaceutical, lifestyle, and digital approaches for Alzheimer’s prevention and treatment, with continuing trials aimed at further validating and refining their protocols.[13][5][7]
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