Bone Mineral Density and Vitamin D - many studies
55+ Vitamin D Life pages with BONE MINERAL DENSITY or BONE LOSS in the title
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Meta-analysis of Vitamin D and Bone Mineral Density - April 2023
Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis
Nutr Rev . 2023 Apr 11;81(5):511-530. doi: 10.1093/nutrit/nuac068 behind publisher paywall
Elham Kazemian 1, Ali Pourali 2, Fatemeh Sedaghat 3, Mehrdad Karimi 4, Vahid Basirat 5, Zohreh Sajadi Hezaveh 6 7, Sayed Hossein Davoodi 7, Michael F Holick 8
Context: There is still controversy over the effect of vitamin D3 supplementation on bone health.
Objective: The effects of vitamin D3 supplementation on bone mineral density (BMD) and markers of bone turnover, as well as the dose-response relationship between vitamin D3 and bone health in adults, were evaluated.
Data sources: The PubMed, Scopus, Cochrane, Web of Science, and AGRIS databases were searched for articles published through April 30, 2022. Thirty-nine of the 6409 records identified met the inclusion criteria.
Data extraction: Data were extracted from articles by 2 authors, and data extraction was cross-checked independently. A random-effects model was used to estimate the pooled effect size and the associated 95%CI for the effect of vitamin D3 for each outcome. A one-stage random-effects dose-response model was used to estimate the dose-response relationship between vitamin D3 supplementation and BMD.
Data analysis: Results of meta-analysis showed a beneficial effect of vitamin D3 at the
lumbar spine (standardized mean difference [SMD] = 0.06; 95%CI, 0.01-0.12) and
femoral neck (SMD = 0.25; 95%CI, 0.09-0.41).
Dose-response analysis revealed a linear relationship between vitamin D3 supplementation doses and
BMD at the femoral neck,
lumbar spine, and
total hip sites.
No significant effect of vitamin D3 supplementation on whole-body or total hip BMD was observed (P > 0.05). Vitamin D3 supplementation significantly decreased BMD at both proximal and distal forearm (SMD = -0.16; 95%CI, -0.26 to -0.06). The variables of ethnicity, age, baseline 25-hydroxyvitamin D (25[OH]D), menopause status, vitamin D3 dosing frequency, and bone health status (P interaction = 0.02) altered the effect of vitamin D3 supplementation on BMD. Additionally, a nonlinear relationship between vitamin D3 supplement doses and markers of bone turnover was found.
Conclusion: A protective effect of vitamin D3 supplementation on BMD of the lumbar spine, femoral neck, and total hip is implicated.
Accelerated bone loss in late reproductive-aged and perimenopausal women with vitamin D insufficiency – Sept 2024
Journal of Bone and Mineral Metabolism PDF behind paywall
Min-Jeong Kim, Sunmie Kim, Jin Ju Kim & Kyung Hee Han
Introduction
The association between serum vitamin D levels and bone mineral density (BMD) varies by race and gender. This study aimed to evaluate this relationship between serum vitamin D levels and BMD, and changes of BMD over time in Korean women.
Materials and methods
We analyzed data from 586 generally healthy Korean women aged 29–79 who underwent health check-ups at Seoul National University Gangnam Center between 2010 and 2011 (baseline measurement) and 2015–2016 (follow-up). Dual energy X-ray absorptiometry (DEXA) and serum 25-hydroxyvitamin D (25OH-D) level measurements were conducted. We assessed the association between serum 25OH-D levels and BMD, as well as changes in BMD over time.
Results
The mean age of participants was 51.3 ± 7.9 years, with a mean follow-up interval of 4.6 ± 0.7 years, and mean serum 25OH-D level of 20.6 ± 8.5 ng/ml. Baseline serum 25OH-D levels did not correlate with BMD values at the lumbar spine, femoral neck, or total femur, nor with changes in BMD over time. A significant negative association was found between perimenopausal status and BMD changes at all sites, and between premenopausal status and lumbar bone mass, compared to postmenopausal status in the 25OH-D < 20 ng/ml group. This association was not observed in women with higher serum 25OH-D levels.
Conclusions
Serum 25OH-D levels did not correlate with BMD levels or changes in BMD overall. However, in late reproductive-aged and perimenopausal women with serum 25OH-D insufficiency, there was a significant association with accelerated bone loss.
Vitamin D Life – Bone - Health category contains
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Vitamin D Life – Overview Osteoporosis and vitamin D contains
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Vitamin D Life - studies in both categories Bone AND Osteoporosis
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