COVID symptoms improved in 7 instead of 10 days with 600,000 IU Vitamin D2 injection

Vitamin D Supplementation Improves Serological Parameters and Recovery Outcomes in COVID-19 Patients

Endocr Metab Immune Disord Drug Targets. 2026 Mar 11. doi: 10.2174/0118715303457486260113044737

Zhaoying Chen 1, Jianping Sheng 2, Qihang Ma 3, Wanpeng Wang 4, Lijie Wang 2, Lin Yang 2, Lin Liu 1, China

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Introduction: This study aimed to investigate the effects of vitamin D on serological, etiological, and imaging indicators in patients with Coronavirus Disease 2019 (COVID-19), exploring new strategies for its prevention and treatment.

Methods: In this retrospective observational study, 300 COVID-19 patients admitted between January 2022 and March 2023 were enrolled from a public health center and our hospital. Participants were stratified into standard treatment (n=150) and vitamin D supplementation (n=150) groups. Outcomes included clinical recovery and improvements in laboratory, etiological, and imaging findings.

Results: No significant intergroup differences were observed at baseline in demographic or laboratory parameters, including white blood cell (WBC), neutrophil (NEUT), lymphocyte (LYM), interleukin (IL)-6, c-reactive protein (CRP), procalcitonin (PCT), and serum calcium (P > 0.05). Both groups exhibited subnormal 25(OH)D levels initially. After adjusting for age, sex, hypertension, diabetes, and cardiovascular and cerebrovascular diseases, multivariable linear regression analyses indicated that the vitamin D group showed significant increases in 25(OH)D and serum calcium, while the standard treatment group exhibited only a mild increase in 25(OH)D with no significant change in serum calcium after treatment. Both groups showed decreases in WBC, NEUT, IL-6, CRP, and PCT, and increases in LYM after treatment. Compared with the standard group, the vitamin D group had greater improvements in NEUT, LYM, 25(OH)D, and serum calcium (P < 0.05), and more pronounced reductions in IL-6 and CRP (P < 0.05). Symptom resolution and viral clearance times were significantly shorter in the vitamin D group (P < 0.05), and imaging improvements were more evident (P < 0.05).

Conclusion: Supplementation with vitamin D, in addition to standard treatment, improves inflammatory markers, shortens the disease course, and is associated with radiographic improvement in COVID-19 patients.

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Nanoemulsion D3 should have produced a much faster response

  • 60 days: Response to Injection
  • 7 days: Response to Oral vitamin D3
  • 2 days: Response to nanoemulsion Vitamin D3 swished in mouth

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Created March 2026
Tags: 60000 Vitamin D2
URL: http://vitad.org/pages/covid-symptoms-improved-in-7-instead-of-10-days-with-600000-iu-vitamin-d2-injection/
Printed March 21, 2026