Diabetes changes liver genes so as to destroy (catabolize) Vitamin D

Expression pattern of CYP24 in liver during ageing in long-term diabetes

Acta Histochemica. Available online 9 May 2016, doi:10.1016/j.acthis.2016.05.001

Ana Vuicaa, Katarina Vukojevića, b, Lejla Ferhatović Hamzićc, Milka Jerića, Livia Puljakc, Ivica Grkovića, Natalija Filipovića, b, ,

This is why diabetes seems to consume vitamin D, it distroys it.It seems that CYP24A1 is associated with the Kidney, but the Liver may have it as wellI am confused about differences between CYP24 and CYP24A1Genetics category listing contains the following {include}---Chart from the web shows that CYP24A1 (which destroys Vitamin D) is normally activated by diabetes (2), but is deactivated by addition of Vitamin D (3) in rats

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Association of liver calcitriol (active vitamin D metabolite) catabolism with osteomalacia during prolonged use of certain drugs was reported in several recent studies. To examine whether the increased calcitriol catabolism could be a potential link between ageing/diabetes mellitus (DM) and bone loss, we studied the dynamic of expression of CYP24, the main calcitriol catabolising enzyme in the liver of rats during ageing and a long-term experimental DM1. DM1 model was induced with intraperitoneally injected streptozotocin (STZ) (55 mg/kg). Sprague-Dawley rats were sacrificed 6 and 12 months after the DM1 induction. The immunohistochemical analyses of CYP24 and transforming growth factor ß 1 (TGF-ß1) expression in the liver were performed. We found that ageing and long-term DM1 resulted in a significantly increased expression of CYP24 in hepatocytes, as well as in non-hepatocyte liver cells (Kupffer cells, hepatic stellate cells and sinusoidal endothelial cells). Ageing and long-term DM1 resulted in an increased expression of TGF-ß1 as well. Expression of CYP24 coexisted with the expression of TGF-ß1 in all types of hepatic cells.

We concluded that liver has the capacity for an active vitamin D catabolism in different populations of liver cells, especially in sinusoidal endothelial cells, through an expression of CYP24. That capacity is substantially increased during ageing and long-term diabetes mellitus. Increased liver calcitriol catabolism could be one of the mechanisms of the bone metabolism impairment related to ageing and diabetes.