Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT

Created April 2018

Omega-3 fatty acids for a better mental state in working populations - Happy Nurse Project: A 52-week randomized controlled trial

Journal of Psychiatric Research, Volume 102, July 2018, Pages 72–80, https://doi.org/10.1016/j.jpsychires.2018.03.015

Norio Watanabea, , , Yutaka Matsuokab, , Mie Kumachic, , Kei Hamazakid, , Masaru Horikoshie, , Toshi A. Furukawaa,

1. Vitamin D and Omega-3 category starts with{include}--- 1. # Items in both categories Omega-3 and Depression are listed here:{category} 1. # Items in both categories Omega-3 and Sleep are listed here:{category}---* Omega-3 reduces many psychiatric disorders – 2 reviews 2016* Depression – is it reduced by Vitamin D and or Omega-3 – RCT 2019* People felt less aggression after just 6 weeks of Omega-3 – RCT Dec 2017* Increasing Omega-3 reduces heart problems, autism, depression, preterm birth, breast cancer, etc.* Omega-3 improves gut bacteria, reduces inflammation and depression – Dec 2017* 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017* Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017* Live longer if high Vitamin D or Omega-3 (probably both)Depression reduced by Vitamin D as well* Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc. Feb 2018* Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014 1. Anxiety studies include{include}

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📄 HADS questionare from the web A lower HADS number is better

Highlights

•The effectiveness of omega-3 PUFAs for prevention of depression was examined.

•Eighty nurses were randomly allocated to omega-3 or placebo for 13 weeks.

•Information about depression, anxiety and presenteeism was collected up to 52 weeks.

•No clinically important difference was comfirmed between two intervention arms.

The efficacy of omega-3 fatty acids for maintaining a better mental state has not been examined among working populations. We aimed to explore the effectiveness of omega-3 fatty acids for hospital nurses. In a multi-center randomized trial, 80 junior nurses were randomly allocated to either omega-3 fatty acids (1200 mg/day of eicosapentaenoic acid and 600 mg/day of docosahexaenoic acid) or identical placebo pills for 13 weeks. The primary outcome was the total score of the Hospital Anxiety and Depression Scale (HADS), determined by a blinded rater at week 26 from the study enrollment.

Secondary outcomes included the

  • total score of the HADS at 13 and 52 weeks;

  • incidence of a major depressive episode;

  • severity of depression, anxiety, insomnia, burnout, and

  • presenteeism;

  • utility scores; and

  • adverse events at 13, 26 and 52 weeks.

The mean HADS score at baseline was 7.2.

At 26 weeks, adjusted mean scores on the HADS were

  • 6.32 (95% CIs of standard errors: 5.13, 7.52) in the intervention and

  • 6.81 (5.57, 8.05) in the placebo groups, respectively.

The coefficient of the group by time interaction was not statistically significant at 0.58 (−1.35, 2.50; P = 0.557).

Although the intervention group showed

  • significant superiority on the HADS score at 52 weeks,

  • depression severity at 52 weeks,

  • insomnia severity at 13 weeks, and

  • absolute presenteeism at 26 weeks,

    • no significant superiority or inferiority was observed on the other outcomes.

The additive value of omega-3 fatty acids was not confirmed regarding mental state and self-evaluated work efficiency.

Tags: Depression Omega-3 Sleep