More lung capacity (bronchial asthma, FEV1) associated with higher vitamin D

Vitamin D and phenotypes of bronchial asthma

Egyptian Journal of Chest Diseases and Tuberculosis. Available online 5 July 2013

R. Eman Shebl a, [email protected]

Samah M. Shehata a,

Maha Elgabry a,

Salah A.I. Ali b,

Hanaa H. Elsaid b

a Department of Chest Diseases, Faculty of Medicine, Zagazig University, Egypt

b Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt

Background

Many studies have suggested the role of vitamin D deficiency in both T-helper1 and T-helper2 diseases. The existence of associations of vitamin D with asthma and allergy remains uncertain. While some suggest that vitamin D may be protective, others suggest that vitamin D supplementation may increase the risk of allergy.

Aim of the work

The aim of the study was to evaluate the state of vitamin D in asthmatic patients and its potential relationship with asthma phenotypes.

Patients and methods

This study was conducted on 66 nonsmoker asthmatic patients and 30 healthy controls. Serum 25-hydroxy vitamin D3 levels were determined and compared between the two groups.

The relationship between serum vitamin D levels and asthma phenotypes were examined.

Results

Vitamin D level was significantly lower in asthmatic patients than in control group, in asthmatic patients, vitamin D levels had a significant positive correlation with FEV1% predicted and a significant negative correlation with body mass index, the number of atopic patients was significantly higher in bronchial asthma patients with vitamin D insufficiency than those with sufficient vitamin D.

Conclusion

Vitamin D deficiency was highly prevalent in asthmatic patients and it was associated with atopy and asthma severity.

Volume of breath exhaled in 1 second vs. vitamin D

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