Much less depression if higher than 43 ng of vitamin D

Depression is associated with low levels of 25-hydroxyvitamin D among Jordanian adults: results from a national population survey.

Eur Arch Psychiatry Clin Neurosci. 2012 Jun;262(4):321-7. doi: 10.1007/s00406-011-0265-8. Epub 2011 Oct 13.

Jaddou HY, Batieha AM, Khader YS, Kanaan SH, El-Khateeb MS, Ajlouni KM.

Department of Community Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. [email protected]

Although low serum 25-hydroxyvitamin D (25(OH)D) and elevated serum parathyroid hormone (PTH) have been associated with depression in clinical settings, this link in community-dwelling individuals is inconclusive. The present study aimed at examining the association between serum 25(OH)D and PTH levels and the presence of depression in a national population-based household sample of 4,002 Jordanian participants aged ?25 years . The DASS21 depression scale was used to screen for depression, and serum concentrations of 25(OH)D and PTH were measured by radioimmunoassay. Multiple logistic regression models were used to explore the association between serum 25(OH)D and PTH levels and depression.

The unadjusted odds ratio (OR) decreased linearly with increasing quartiles of serum 25(OH)D (P(trend) = 0.00). The OR for having depression was significantly higher among individuals in the first and second quartiles (OR = 1.4 , 1.23, respectively) than among those in the fourth quartile (P values = 0.00 and 0.03, respectively).

This relationship remained significant after adjusting for age, sex, marital status, education, BMI, serum creatinine, number of chronic diseases (OR = 1.39 and 1.21 and P values = 0.00 and 0.05, respectively) and after further adjustment for exercise, altitude, and smoking (OR = 1.48 and 1.24, respectively, and P values = 0.00 and 0.03, respectively).

No significant association was found between serum PTH levels and depression.

The decrease in risk of depression among participants started to be significant with serum 25(OH) D levels higher than 42.3 ng/ml (lower limit of the range of the third quartile). This value may help pinpoint the desirable level of serum 25(OH)D to be attained to help aid the prevention and treatment of depression.

PMID: 21993566

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Summary by Vitamin D Life

• 40% increased chance of depression if low vitamin D (does not state what the lower level is)

• Less depression for vitamin D levels > 43 ng/ml

See also Vitamin D Life - Depression

• All items in category Winter Blues/Depression and Vitamin D items

• Depression 50 % more likely if low vitamin D in early pregnancy – Aug 2012

• Less than 20 ng vitamin D increases depression by 80 percent – Dec 2010

• Pregnant blacks 50 % more likely to be depressed if 3 ng less vitamin D – July 2012

• High levels of vitamin D associated with somewhat less depression – Mayo Nov 2011

• Depression 40 % more likely if low vitamin D – Oct 2011

• 36 % less depression when have high level of vitamin D – July 2011

• Teens no longer depressed after vitamin D raised to 36 ng – Feb 2012

  • The teen study used a loading dose for 1 month, and got great results in just 3 months

• Depression in UAE peaks in the summer – probably due to sun avoidance – Feb 2011

• Depression book talks about vitamin D - Nov 2012

• Mental health problems cut in half when have adequate level of vitamin D – Jan 2013

See also Vitamin D Life - Mental Illness

• Overview Cognition and vitamin D for seniors

• Psychosis in dark skinned people 3.5 X higher if low level of vitamin D – May 2012

• Mental Illness and Vitamin D from Vitamin D Counci

• Hypothesis: Some Mental Illness could be treated or prevented with vitamin D

• Psychiatric disorders 4X more likely in teens if low vitamin D - Nov 2011

See also web- Depression

• Clinical Trials for Depression with vitamin D intervention 27 INTERVENTION trials listed as of Sept 2013
  • Random controlled trials to see if vitamin D reduces depression.
  • However, it appears that most of the trials are only using 2800 IU of vitamin D, which is probably not enough

See also web

• [http://www.vitamindcouncil.org/health-conditions/depression/|Depression} Vitamin D Council, June 2013

Short url = http://is.gd/vitdepression