Muscles improved in women with 50,000 IU vitamin D weekly (8 weeks) plus daily Magnesium – RCT

Randomized Study of the Effects of Vitamin D and Magnesium Co-Supplementation on Muscle Strength and Function, Body Composition, and Inflammation in Vitamin D-Deficient Middle-Aged Women - Sept 2020

Biological Trace Element Research volume 199, pages 2523–2534 (2021

Fatemeh Kheyruri, Javad Sarrafzadeh, Agha Fatemeh Hosseini, Behnaz Abiri & Mohammadreza Vafa

This study aimed to investigate the effects of vitamin D and magnesium co-supplementation on muscle strength and function, body composition, and inflammation in vitamin D-deficient middle-aged women. In this study, 83 healthy middle-aged women (40–55 years) with vitamin D deficiency were randomly assigned into two groups: (1) intervention: receiving a 50,000-IU vitamin D soft gel (weekly) plus a 250-mg magnesium tablet (daily); (2) control: receiving a vitamin D placebo (weekly) plus a magnesium placebo (daily), for 8 weeks. Before and after the intervention, anthropometric indices, muscle strength, muscle function, and some inflammatory markers were measured. After 8 weeks of supplementation, significant difference was observed in handgrip strength and time for Time Get Up and Go (TGUG) test between the intervention and placebo groups (P < 0.05). Regarding percentage of fat mass (FM%) and fat free mass (FFM%), and knee extension strength, there was no significant difference between the two groups at the end of intervention (P > .05). Serum 25(OH)-D levels increased significantly (P < 0.001) and its change was significantly different between the two groups, at the end of the intervention (P < 0.001). Serum level of hs-CRP decreased significantly in the intervention group compared to baseline (P < 0.001), and the change in hs-CRP was significant between the two groups at the end of the intervention (P < 0.01). Furthermore, serum level of TNF-α declined significantly in the intervention group compared to baseline (P < 0.001) but, no significant differences were seen between the two groups in regard of serum levels of TNF-α and IL-6 after the intervention (P > 0.05).

Our findings show that vitamin D and magnesium co-supplementation, for 8 weeks, in healthy middle-aged women with vitamin D deficiency have beneficial impacts on muscle strength, muscle function, and probably inflammation.

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Muscle improvement RCT with 50,000 IU of Vitamin D (no Magnesium) - Aug 2019

Muscle strength and quality of life improved after vitamin D supplementation among adult Saudi females

Clinical Nutrition Experimental Vol 26, August 2019, Pages 34-43 https://doi.org/10.1016/j.yclnex.2019.04.002

Mohammed Ewid a b, Mohammed AlTelbany c, Syed Muhammad Baqui Billah a, Nazmus Saquib a, Akram Helmy d, Saadi AlJundi a, Tawfik Rajab a, Saed Enabi a, Ahmed AlShwaikh a, Abdullah Morhaf a, Hossam Sherif a e

Background & aims

Physical and mental well-being following vitamin D supplementation shows contradictory data in the literature. We aimed to explore this more among young and middle-aged Saudi females suffering from vitamin D deficiency by analyzing handgrip strength and self-reported quality of life.

Methods

Fifty-eight females with bone or muscle aches attending the outpatient orthopedics clinic of an area hospital were enrolled after informed consent. Each participant filled out the SF-8™ questionnaire for quality of life (QOL) and was assessed for demographic/behavioral data, serum level of 25-hydroxyvitamin D (25(OH)D), and handgrip (HG) for both hands at baseline and 3 months after standard 25(OH)D oral supplementation.

Results

The mean age was 31.9 ± 7.3 years; serum 25(OH)D values increased significantly after the oral supplementation (11.28 ± 4.1, range 4.2–22 vs. 23.98 ± 6.81, range 7–41.4 μg/dl, P < 0.001) The handgrip mean for both hands after 25(OH)D supplementation also showed statistically significant higher values (13.24 ± 4.95, range 5–25.33 vs. 17.76 ± 4.39, range 9.5–27.33 kg/m2, P < 0.001). The SF-8™ QOL questionnaire results showed an overall statistically significant improvement (P < 0.001). 25(OH)D baseline values predicted muscle weakness; area-under-the-curve was 63% (95% CI: 47–79%) with the best cut-off value at 17.17 μg/dl (sensitivity 64% and specificity 62%).

Conclusion

Adult Saudi females showed improved muscle strength and quality of life following standard 25(OH)D oral supplementation.

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