Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis

Created November 2019

Vitamin D Receptor Polymorphisms Associated with Susceptibility to Obesity: A Meta-Analysis.

Med Sci Monit. 2019 Nov 4;25:8297-8305. doi: 10.12659/MSM.915678.

Items in both categories Obesity and Vitamin D Receptor are listed here: {category}---The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019Vitamin D Receptor Activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, non-daily Vitamin D dosing, etc     Note: The founder of Vitamin D Life uses 10 of the 12 known VDR activators---Overview Obesity and Vitamin D contains the following summary{include}---Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 has the following{include}

Chen X1, Wang W2, Wang Y1, Han X1, Gao L3.

  • 1 Endocrine Metabolic Disease Section, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China (mainland).

  • 2 Anorectal Department, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China (mainland).

  • 3 College of Basic Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China (mainland).

BACKGROUND Obesity has become a global public health problem. Obesity increases the risk of several lethal diseases. This study aimed to assess whether the obesity susceptibility was associated with genetic variation in vitamin D receptor (VDR) gene by conducting a meta-analysis.

MATERIAL AND METHODS PubMed, EMBASE and Cochrane Library databases were screened for all relevant articles published up to October 2018. The pooled odds ratios (OR) were calculated using STATA 13.0 software for 4 polymorphisms in the VDR gene (ApaI, BsmI, FokI and TaqI).

RESULTS Seven case-control studies, including 1188 obese patients and 1657 healthy controls, were recruited. The pooled findings showed that there were no associations between obesity risk and the VDR polymorphisms in ApaI, BsmI and TaqI loci overall. However, VDR TaqI polymorphism was associated with the risk of obesity in Asian under homozygous [TT versus tt: odds ratio (OR)=0.26, 95% confidence interval (CI)=0.14-0.49; P<0.001], heterozygous (Tt versus tt: OR=0.34, 95% CI=0.18-0.64; P=0.001), and dominant (TT+Tt versus tt: OR=0.30, 95% CI=0.17-0.52; P<0.001) models; FokI variant was related with increased risk of obesity only under dominant model (FF+Ff versus ff: OR=1.54 , 95% CI=1.15-2.06; P=0.004).

CONCLUSIONS Our meta-analysis results suggest that the T allele of TaqI may have a protective effect, while the F allele of FokI is proposed as a risk factor related to obesity.

Tags: Meta-analysis Obesity Vit D Receptor Women