Prediabetes reduced in half by those getting Magnesium Chloride – RCT

Created May 2015

Oral magnesium supplementation improves glycaemic status in subjects with prediabetes and hypomagnesaemia: A double-blind placebo-controlled randomized trial

Diabetes & Metabolism. doi:10.1016/j.diabet.2015.03.010, Available online 27 April 2015

F. Guerrero-Romero, L.E. Simental-Mendía, G. Hernández-Ronquillo, M. Rodriguez-Morán [email protected]

Patients had, like most people, low levels of Magnesium382 mg of Magnesium element per day in the form of Magnesium Chloride for 4 months 1. || |Magnesium Chloride|Placebo|Unitsfollow-up fasting |87 |98 |mg/dLpost-load glucose |125 |137| mg/dL HOMA-IR indices |2.9|4.1 |Triglycerides |166| 227|Serum magnesium |2.0 |1.6 |mg/dL||Note: serum Magnesium tests cost > $100Magnesium deficiency is exceeded only by Vitamin D deficiency globallyThere are scores of reasons to restore Magnesium levels to where they were 50 years agoSee also Vitamin D Life* Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020* All-cause mortality is related to low Magnesium, rather than low Vitamin D – April 2015* If at high risk of vitamin D deficiency, get a higher response if take more Magnesium – Sept 2013* thus MgCl could have just increased Vtiamin D levels - where were not measured by study on this page* Magnesium and Vitamin D very synergistic – Aug 2013* thus MgCl could have just increased Vtiamin D levels - which were not measured by study on this page* Prediabetes both prevented and treated by monthly Vitamin D, etc.* Drugs Deplete MagnesiumPages listed in BOTH the categories Diabetes and Magnesium{category}

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Aim

This study evaluated the efficacy of oral magnesium supplementation in the reduction of plasma glucose levels in adults with prediabetes and hypomagnesaemia.

Methods

A total of 116 men and non-pregnant women, aged 30 to 65 years with hypomagnesaemia and newly diagnosed with prediabetes, were enrolled into a randomized double-blind placebo-controlled trial to receive either 30 mL of MgCl2 5% solution (equivalent to 382 mg of magnesium) or an inert placebo solution once daily for four months. The primary trial endpoint was the efficacy of magnesium supplementation in reducing plasma glucose levels.

Results

At baseline, there were no significant statistical differences in terms of anthropometric and biochemical variables between individuals in the supplement and placebo groups. At the end of follow-up fasting (86.9 ± 7.9 and 98.3 ± 4.6 mg/dL, respectively; P = 0.004) and post-load glucose (124.7 ± 33.4 and 136.7 ± 23.9 mg/dL, respectively; P = 0.03) levels, HOMA-IR indices (2.85 ± 1.0 and 4.1 ± 2.7, respectively; P = 0.04) and triglycerides (166.4 ± 90.6 and 227.0 ± 89.7, respectively; P = 0.009) were significantly decreased, whereas HDL cholesterol (45.6 ± 10.9 and 46.8 ± 9.2 mg/dL, respectively; P = 0.04) and serum magnesium (1.96 ± 0.27 and 1.60 ± 0.26 mg/dL, respectively; P = 0.005) levels were significantly increased in those taking MgCl2 compared with the controls. A total of 34 (29.4%) people improved their glucose status (50.8% and 7.0% in the magnesium and placebo groups, respectively; P < 0.0005).

Conclusion

Our results show that magnesium supplementation reduces plasma glucose levels, and improves the glycaemic status of adults with prediabetes and hypomagnesaemia.

Tags: Diabetes Magnesium