Rapid Normalization of Vitamin D in Critically Ill Children (10,000 IU per kg) – clinical trial

Rapid Normalization of Vitamin D in Critically Ill Children: A Phase II Dose Evaluation Randomized Controlled Trial (VITdAL-PICU)

NCT02452762 – Start Dec 2015, End Dec 2018

For critically ill children from birth to age 18 and blood 25OHD less than 50 nmol/L

10000 IU/kg of cholecalciferol (max 400,000 IU)

Second dose if low Day 3 blood test

<50 nmol - 2nd loading dose of 10,000 IU/kg (max 400,000IU)

50-75 nmol -2nd loading dose of 50,00 IU/kg (max 400,000IU)

See also Vitamin D Life

• Overview Loading of vitamin D

• Children in Intensive Care need Vitamin D loading dose of 10000 IU per kg (nearing a consensus) - Oct 2016

• Bio-available Vitamin D following mega-doses (up to 500,000 IU) – Clinical trial due 2018

• Clinical trials using a LOT of vitamin D intervention – Jan 2015

• Vitamin D loading doses of up to 400,000 IU OK for adolescents – meta-analysis Dec 2014

• Normalize vitamin D safely within 1-2 weeks – June 2014

  Pages listed in BOTH of the categories Loading Dose and Infant/Child

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