Some Rickets is due to poor genes - Vitamin D needed lifelong

Diagnosis and Management of Vitamin D Dependent Rickets

Front. Pediatr., 12 June 2020 | https://doi.org/10.3389/fped.2020.00315

Michael A. Levine*

Center for Bone Health and Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States

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Note by Vitamin D Life - Vitamin D values seem to be about 40X too large - perhaps should be IU, not micrograms

The term “vitamin D dependent rickets” describes a group of genetic disorders that are characterized by early-onset rickets due to the inability to maintain adequate concentrations of active forms of vitamin D or a failure to respond fully to activated vitamin D. Although the term is now admittedly a pathophysiological misnomer, there remains clinical relevance for its continued use, as patients have a lifelong “dependency” on administration of specialized regimens of vitamin D replacement. This review provides an update on the molecular bases for the three forms of vitamin D dependent rickets, and summarizes current protocols for management of affected subjects.