Vitamin D for infants – 100,000 IU monthly is better than 400 IU daily – RCT

Created January 2021

Effect of vitamin D supplementation as a single dose on the nutritional status of vitamin D

Revista Chilena de Pediatría 2020, 91 (5): 684-690 (study is in Spanish)

Johanna Pacheco-Acosta, Fernando Pizarro

100K was better because more of them have vitamin D levels between 30 and 40 ng 1. Infant-Child category has items and starts with{include}{include}Better than Daily category listing has items* 44 percent of successful RCTs in Vitamin D Life used non-daily dosing - Nov 2020* Vitamin D every 25 days may be BETTER than daily – RCT May 2018* Vitamin D – monthly dosing was better than daily with Calcium – RCT Dec 2015Items in both categories Infant-Child and Intervention - non daily are listed here: {category}

📄 Download the PDF from Vitamin D Life

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INTRODUCTION: Infants are a group at risk of vitamin D (VD) deficiency. The administration of 400 IU of VD per day during the first year of life does not achieve 100% adherence. A single dose of 100,000 IU of oral VD is safe in newborns.

OBJECTIVE: To compare the effect of oral administration of VD between a single dose of 100,000 IU at one month of age vs daily doses of 400 IU on serum concentrations of VD, at 6 months of age.

SUBJECTS AND METHOD: Randomized clinical trial, without masking. 84 healthy infants were included at 1 month of age, randomized to the study group (SG) receiving a single oral dose of 100,000 IU or to the control group (CG), who received daily oral doses of VD of 400 IU from the 1st to the 6th month of life. At 6 months of life, the serum concentration of VD was determined.

RESULTS: 65 infants completed the study, 36 in SG and 29 in CG. No VD deficiency was found.

VD insufficient was 5.5% and 6.8% in the SG and CG, respectively.

The serum concentration of VD at six months of age was 38.8 ± 5.2 ng/ml and 39.7 ± 6.3 ng/ml for the SG and CG, respectively (NS).

CONCLUSIONS: Supplementation of 100,000 IU of VD at one month age achieves serum concentrations of VD at 6 months of life similar to the administration of daily doses of 400 IU of VD from the 1st to the 6th month.

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A randomized clinical trial was conducted, without blinding, which included 84 healthy infants (42 per group) between August 15, 2015, and July 15, 2016, who attend well-baby checkups at the Padre Vicente Irarrázaval Family Health Center (CESFAM), Santia go (Latitude 33°S). We included full-term newborns between 25 and 45 days of age, fed with exclusive or mainly breast milk, with the written informed consent of their parents or representative of legal age.

Tags: Infant-Child Intervention Intervention - non daily