Vitamin D insufficiency was 3.7 X more likely if CYP2R1 gene variation

Created June 2015

Genetic Variation in CYP2R1 and GC Genes Associated With Vitamin D Deficiency Status

Journal of Pharmacy Practice online before print June 2, 2015; 0897190015585876

Nicole A. Slater, PharmD 1

Michelle L. Rager, PharmD 2 [email protected]

Dawn E. Havrda, PharmD 2

Arthur F. Harralson, PharmD 3

1Department of Pharmacy Practice, Harrison School of Pharmacy, Auburn University, Mobile AL, USA

2Department of Pharmacy Practice, Bernard J Dunn School of Pharmacy, Shenandoah University, Winchester, VA, USA

3Department of Pharmacogenomics, Bernard J Dunn School of Pharmacy, Shenandoah University, Winchester, VA, USA

Insufficiency(< 30 ng) in 78% of 180 patients| | || --- | --- || Gene | Risk of < 30 ng || CYP2R1 (rs10741657) | 3.7 X || GC (rs2282679) | 2.4 X || VDR (rs2228570) | - || DHCR7 (rs12785878) | - |See also Vitamin D Life* CYP2R1 gene problem increases Multiple Sclerosis risk by 1.4X – Dec 2018* Vitamin D suppressed by Roundup and Genes - CYP2R1, CYP24A1, CYP450 etc.* CYP2R1 mutations also cause vitamin D-deficient rickets – July 2016Genetics category listing contains the following{include}

This cross-sectional study enrolled 180 patients at a private family practice in Virginia. Total serum vitamin D concentrations were obtained weekly from January 30, 2013, through March 30, 2013, in consecutive patients regularly scheduled for laboratory work at the practice. Patients were categorized into 2 groups and analyzed for variant alleles in

  • vitamin D receptor (VDR; rs2228570),

  • cytochrome P450 2R1 (CYP2R1; rs10741657),

  • 7-dehydrocholesterol reductase (DHCR7; rs12785878), and

  • group-specific component (GC; rs2282679)

to determine whether variants of those alleles influenced total serum 25(OH)D concentrations. One-hundred and eighty patients were enrolled, with 40 (22%) being sufficient, 25-hydroxy vitamin D level 25(OH)D ≥ 30 ng/mL, and 140 (78%) being insufficient, 25(OH)D < 30 ng/mL. Of the 4 genes, 2 genes, CYP2R1 (rs10741657) and GC (rs2282679), demonstrated a significant association related to vitamin D status. Subjects with 1 or more variant alleles at rs10741657 were almost 3.7 (odds ratio [OR] 3.67; 95% confidence interval [CI]: 1.35-9.99) times more likely be insufficient in vitamin D and subjects with 1 or more variant alleles at rs2282679 were about half (OR 0.42; 95% CI: 0.18-0.93) as likely to be insufficient in vitamin D.

Allelic variations in CYP2R1 (rs10741657) and GC (rs2282679) affect vitamin D levels, but variant alleles on VDR (rs2228570) and DHCR7 (rs12785878) were not correlated with vitamin D deficiency, 25(OH)D < 30 ng/mL.

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Tags: Genetics