Vitamin D: need 30 to 60 ng (50,000 IU weekly) RCT (Russia)
OPTIMAL 25(OH)D SERUM LEVEL IN RELATION TO ASSOCIATION WITH MUSCULOSKELETAL, METABOLIC, NEUROLOGICAL, AUTOIMMUNE AND INFECTIOUS DISEASES
Problems of Endocrinology 2025;71(6):40-49 https://doi.org/10.14341/probl13687
E.A. Troshinal , E.A. Pigaroval *, T.L. Karonova2 , F.Kh. Dzgoeval , V.E. Radzinsky3 , I.I. Baranov4 p.M. Lesnyak5 , Yu.E. Dobrokhotova6 , I.V. Kuznetsova7 , N.V. Zarochentseva8 , G.R. Bayramova4 , P.A. Radaeva9 , E.V. Ekusheva10, L.A. Suplotovall, E.V. Matushevskaya10
This article presents an overview of current research on target vitamin D blood levels. It examines the biochemical and metabolic properties of vitamin D, as well as the challenges of standardizing 25(OH)D measurements and the variability of cutoff values across populations. It discusses the ambiguity of the scientific evidence and the need to consider individual factors when interpreting vitamin D levels. This review is unique in its comprehensive approach to analyzing the effects of vitamin D not only on bone health but also on immune and metabolic function, expanding the evolving understanding of the clinical significance of vitamin D. This paper emphasizes the importance of personalized recommendations for vitamin D prescription and dosing based on current clinical evidence and scientific standards. This analysis highlights the need for a personalized approach to vitamin D prescription to achieve and maintain blood levels of 30 to 60 ng/mL, noting that higher levels may be required for individuals with genetic or acquired resistance to the nutrient. The data obtained support the development of evidence-based, personalized clinical strategies for the prevention and treatment of diseases associated with vitamin D deficiency. The synthesized data are important for the development of research and clinical practice in the fields of endocrinology, obstetrics, dermatology, neurology, and immunology.
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Russia