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Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015

Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial.

Public Health Nutr. 2015 Mar 20:1-8. [Epub ahead of print]
Karamali M 1, Asemi Z 2, Ahmadi-Dastjerdi M 1, Esmaillzadeh A 3.
1 Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran.
2 Department of Nutrition, Research Center for Biochemistry and Nutrition in Metabolic Diseases,Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.
3 Food Security Research Center,Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.

Vitamin D Life Summary and references

60 women with GDM in Iran – randomized half of them supplementing with
50,000 IU vitamin D twice – at day 1 and day 21
1 gram of Calcium daily for 6 weeks

Vitamin D No D
Caesarean section rate 23 % 63 %
Maternal hospitalization 0 %13 %
Infant Macrosomia
(Large for gestational age)
0 % 13 %
Infant hyperbilirubinaemia30 %57 % 

Notes by Vitamin D Life

  1. ~2400 IU daily for Iranian women (who are typically very vitamin D deficient)
  2. Some of the women will probably have had high BMI
  3. Vitamin D dose needed for high BMI is 2-3 more than for normal BMI ((dose did not vary with weight in this study)
  4. Unsure if the Calcium is needed

See also Vitamin D Life

See also web
Increasing Prevalence of Gestational Diabetes and Pregnancy-Related Hypertension in Los Angeles County, California, 1991–2003

Gestational diabetes (top of chart = 1%)
Image

Racial/Ethnic Differences in the Percentage of Gestational Diabetes Mellitus Cases Attributable to Overweight and Obesity, Florida, 2004-2007
Image

Gestational Diabetes Risk Factors Mayo Clinic
Age greater than 25, Family or personal health history,BMI> 30, Nonwhite race
WebMD adds the following factors
Previously giving birth to a baby over 9 pounds, given birth to a stillborn baby, previously had gestational diabetes


OBJECTIVE:
The present study was designed to assess the effects of Ca+vitamin D supplementation on pregnancy outcomes in women with gestational diabetes mellitus (GDM).

DESIGN:
A randomized, double-blind, placebo-controlled trial was conducted among sixty women with GDM. Participants were divided into two groups to receive Ca+vitamin D supplements or placebo. Individuals in the Ca+vitamin D group (n 30) received 1000 mg Ca/d and two pearls containing 1250 µg (50 000 IU) of cholecalciferol (vitamin D3) during the intervention (one at study baseline and another at day 21 of the intervention); those in the placebo group (n 30) received two placebos of vitamin D at the mentioned times and placebos of Ca every day for 6 weeks. Pregnancy outcomes were determined.

SETTING:
A urban community setting in Arak, Iran.

SUBJECTS:
Sixty women with GDM and their newborns, living in Arak, Iran were enrolled.

RESULTS:
Women treated with Ca+vitamin D had a significant decrease in caesarean section rate (23·3 % v. 63·3 %, P=0·002) and maternal hospitalization (0 v. 13·3 %, P=0·03) compared with those receiving placebo. In addition, newborns of GDM women randomized to Ca+vitamin D had no case of macrosomia, while the prevalence of macrosomia among those randomized to placebo was 13·3 % (P=0·03). Lower rates of hyperbilirubinaemia (20·0 % v. 56·7 %, P=0·03) and hospitalization (20·0 % v. 56·7 %, P=0·03) were also seen in the supplemented group of newborns than in the placebo group.

CONCLUSIONS:
Ca+vitamin D supplementation for 6 weeks among pregnant women with GDM led to decreased caesarean section rate and maternal hospitalization, and decreased macrosomia, hyperbilirubinaemia and hospitalization in newborns.

PMID: 25790761

Publisher charges $45 for the PDF


Vitamin D Life pages listed in BOTH the categories Diabetes and Pregnancy

Attached files

ID Name Comment Uploaded Size Downloads
5202 GDM vs BMI.jpg admin 21 Mar, 2015 13:59 29.01 Kb 1704
5201 GDM rate.jpg admin 21 Mar, 2015 13:50 32.73 Kb 2838
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