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Overview Parkinsons and Vitamin D

Parkinson's Disease proven to be TREATED by Vitamin D (Many Meta-analyses of trials)

See also on Vitamin D Life

Vitamin D Life Parkinson's and Meta-analysis

See also on web


2 Clinical Trials in progress to confirm that Vitamin D does TREAT Parkinson's Disease

1) Clinical Effects of Vitamin D Repletion in Patients With Parkinson's Disease (VIDIP PILOT)

Estimated completion date Dec 2011 NCT00571285; Contact: Elaine Sperin, LPN [email protected] or : Shirley Triche, RN, FNP striche at emory.edu
General statement of how the problem will be studied About 150 persons who have PD and low vitamin D levels will participate in this study.
Subjects will be randomly (like flipping a coin) assigned to either high dose vitamin D supplement (54,200 IU weekly)
or the Recommended Daily Allowance (RDA) for older persons (4200 IU weekly of vitamin D).
Subjects will be examined in the clinic before, then 3- and 6- months after taking vitamin D supplement.
Tests of walking speed, Parkinson's rating scales, memory tests and questionnaires of mood, anxiety and fatigue will be administered.
Subjects will be randomized (1:1) to one of the following:

  • 50K IU vitamin D weekly plus 600 IU daily (equivalent to 7743 IU daily)
  • OR Placebo capsule once a week plus a daily MVI senior multivitamin (equivalent to 600 IU daily)

Update Dec 2014 - suspended due to lack of funding

2) Effects of Vitamin D in Parkinson's Disease (PD)

Clinical Trial NCT01119131; Start Date: July 2010; Study Ongoing as of July 2015

The proposed study is a randomized, double-blinded, placebo controlled intervention trial to measure the effects of vitamin D at (10,000 IU/day) versus placebo on balance and falls in Parkinson's disease. We will measure static, dynamic, and ambulatory balance, as well as strength, falls, and cognition before and after 16 weeks of therapy. Dynamic posturography will be used to measure static and ambulatory balance, a device called iMOBILITY will measure a timed up and go, and strength will be measured with the Biodex machine checking knee flexion and extension. Multiple quality of life and cognitive tests will also be performed.
Comment by Vitamin D Life - unfortunately only 16 weeks and no loading dose.
It is unlikely that very many of the participants will get a high enough vitamin D level to make any difference in 4 months

Vitamin D Deficiency-Induced Vertebral Fractures May Cause Stooped Posture in Parkinson Disease

American Journal of Physical Medicine & Rehabilitation:
April 2011 - Volume 90 - Issue 4 - pp 281-286
Sato, Yoshihiro MD; Iwamoto, Jun MD; Honda, Yoshiaki MD

Results: During the 5-yr study period, stooped posture developed in 34 patients; the rest of the 58 patients did not show stooped posture. At baseline, mean serum 25-hydroxyvitamin D and parathyroid hormone levels were 10.9 ng/ml and 73.1 pg/ml, respectively, in the stooped group and 18.6 ng/ml and 56.4 pg/ml, respectively, in the nonstooped group. Bone mineral density in the stooped group was significantly lower than in the nonstooped group. Dietary intake of vitamin D in the stooped group was significantly lower than in the nonstooped group.
During the study period, 19 (22%) patients in the nonstooped group developed new vertebral fracture, compared with 23 (100%) patients in the stooped group.
The mean ± SD percentage changes in bone mineral density were ?6.5 ± 0.6 in the stooped group and ?3.8 ± 0.8 in the nonstooped group.
Mean serum levels of 25-hydroxyvitamin D after 5 yrs were 7.0 ng/ml in the stooped group and 14.1 ng/ml in the nonstooped group.

Conclusions: Stooped posture in Parkinson disease may be caused by vertebral fractures resulting from vitamin D deficiency with compensatory hyperparathyroidism.
Vitamin D supplementation may reduce stooped posture in patients with Parkinson disease.

Image from the web


Age Adjusted death from Parkinson's

22% increase in prevelance of Parkinson's(age adjusted) 1990 - 2016
"Age-standardized prevalence rates of Parkinson's disease by country varied greater than five times, with the highest rates generally in high-income North America and lowest rates in sub-Saharan Africa

Age Adjusted Death from Dementia (Finland)"

Dementia death rate - age standardized @is.gd/increasedisease

High prevalence of hypovitaminosis D status in patients with early Parkinson disease.

PMID: 21403017 2011  Download PDF from Vitamin D Life

Remember Vitamin D to forget Parkinson’s disease July 2012

review of 30 year study in Finland lowest levels of vitamin D were three times more likely to develop Parkinson’s, compared with the group with the highest levels of vitamin D.

What is Parkinson's (From MJ Fox)


Review of PD -2013 (which barely mentions vitamin D)

 Download PDF from Vitamin D Life

Epidemiology and etiology of Parkinson’s disease - 2011(which does not mentions vitamin D)

 Download PDF from Vitamin D Life.

Emerging role of Nutrition in PD - vitamin D and Omega-3 are mentioned - 2014

 Download PDF from Vitamin D Life.

CoQ10 1200 mg treats PD (nothing about vitamin D) - LEF 2013

 Download PDF from Vitamin D Life.

Vitamin D and neurology - section on PD Wikipedia March 2014

Parkinson's disease is characterized by progressive deterioration of movement and coordination. Patients with Parkinson's disease lose dopaminergic (DA) neurons in the substantia nigra.,[13] a part of the brain that plays a central role in such brain functions as reward, addiction, and coordination of movement. Studies suggest that low vitamin D levels could play a role in PD, and in one case report, vitamin D supplements lessened parkinsonian symptoms. In a study of vitamin D receptor knockout mice, mice without VDR exhibited motor impairments similar to impairments seen in patients with Parkinson's disease.[6] One proposed mechanism linking vitamin D to Parkinson's disease involves the Nurr 1 gene. Vitamin D deficiency is associated with decreased expression of the Nurr1 gene, a gene responsible for development of DA neurons. It is therefore plausible that a lack of Nurr1 expression leads to impaired DA neuronal development. Failure to form DA neurons would lead to lower dopamine concentrations in the basal ganglia. Additionally, rats lacking Nurr1 exhibited hypoactivity followed by death shortly after birth.[13]

Risk of Dementia reduced 50% by just using Brain Plasticity Software for just 13 hours - Nov 2017

Posit Science - 10 year experiment, full free text online
Speed of processing training results in lower risk of dementia

Manganese increases the Risk of Parkinson's Symptoms (first described in 1837)

  • Excess Manganese in well water
  • Manganese is used for bleaching at pulp paper plants
    • Increased risk of Parkinson's Symptoms if work at a pulp paper plant which which uses Mn
  • Search Google for parkinson's symptoms manganese 750,000 items Jan 2019
  • Manganese and Parkinson's: Mechanism may explain link March 2019
  • Manganese and Parkinson’s Disease: A Critical Review and New Findings - Aug 2010
    • doi: 10.1289/ehp.0901748 FREE PDF
  • Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features - July 2015
    • 10.3390/ijerph120707519 FREE PDF - Note: Parkinsonism is bilateral vs PD affects each side of the body differently
  • Parkinson-like Symptoms Worsen with Long-Term Exposure to Manganese Parkinson's Foundation - 2016
    • "manganese levels can lead to progressive parkinsonism, a disease that mirrors symptoms of Parkinson’s but is a separate disease
  • Manganese in manganism, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Batten disease: A narrative review - 2017
    • DOI: 10.4103/0028-3886.217949, "...The collective evidence to date suggests that environmental exposure to excessive amounts of manganese (Mn) can cause a neurodegenerative condition known as manganism. It is now also relatively clear that Mn is involved in the pathogenesis of Alzheimer's disease and at least some prion diseases. The potential involvement of Mn in a panel of other neurodegenerative conditions including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Batten disease "
  • Metals and Parkinson’s Disease: Mechanisms and Biochemical Processes. Curr. Med. Chem. 2018, 25, 2198–2214.
  • Toxic-Induced Parkinsonism. In Movement Disorders Curricula; Springer: Vienna, Austria, 2017
  • Manganism is a neurological disorder that may occur in response to high inhalation exposures in occupational settings and which is characterized by mood changes and an extrapyramidal syndrome resembling Parkinson disease. 2015 chapter in a book
    • Clumsiness of movement 82%,Exaggeration of reflexes in lower limbs 74%, Hyperemotionalism 71%, Speech disorders 70%, Masque manganique 65%, Spasmodic laughter 47% Difficulty in certain movements 45%, Spasmodic tears 32%, Adiodokinesis 30%

Short URL= is.gd/ParkD

Overview Parkinsons and Vitamin D        
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Attached files

ID Name Comment Uploaded Size Downloads
7484 Gut Parkinson's.pdf PDF 2016 admin 14 Dec, 2016 11:00 2.76 Mb 1510
5092 CoQ10 1200 mg for PD LEF 2013.pdf PDF 2013 admin 23 Feb, 2015 03:33 510.70 Kb 2401
3878 PD nutrition.pdf PDF 2014 admin 06 May, 2014 22:19 609.53 Kb 2917
3701 Epidemiology and etiology of Parkinson’s disease - 2011.pdf admin 15 Mar, 2014 02:05 956.71 Kb 4005
3456 what is parkinsons-small.jpg admin 27 Dec, 2013 14:34 191.35 Kb 12530
3455 sunshine-brain.jpg admin 27 Dec, 2013 04:21 24.13 Kb 11045
2595 Parkinson-Disease overview - 2013.pdf PDF admin 20 Jun, 2013 13:07 152.93 Kb 4009
2054 hypomimia.jpg admin 03 Feb, 2013 16:04 55.05 Kb 12720
801 Parksinsons symptoms.jpg Symptoms admin 06 Oct, 2011 20:10 9.41 Kb 14658
800 9 ng of Vitamin D with Parkinsons - 2010.pdf PDF 9 ng admin 06 Oct, 2011 14:04 286.21 Kb 3139
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