Vitamin D and clinical cancer outcomes: a review of meta analyses
John D Sluyter1, JoAnn E Manson2 3, Robert Scragg1
- 1 School of Population Health, University of Auckland, Private Bag,Auckland, New Zealand.
- 2 department of Medicine, Brigham and Womens Hospital, and Harvard Medical School, Boston, MA, USA.
- 3 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA USA
- Correspondence: Dr John Sluyter, School of Population Health, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. i.sluvter at auckland.ac.nz
Overview Breast Cancer and Vitamin D contains the following summary and sections
- 16+ meta-analyses of Vitamin D and Breast Cancer
example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D. - Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
wonder just how much more proof is needed - Breast Cancer 4X more likely if have poor genes
- Cancer - Breast category listing has
223 items along with related searches
Cancer category starts with the following- Cancer
211 items Overview Cancer and vitamin D - After Cancer Diagnosis
84 items - Bladder Cancer
25 items - Breast Cancer
223 items Overview Breast Cancer and Vitamin D - Colon Cancer
116 items Overview Cancer-Colon and vitamin D - Leukemia
16 items - Liver Cancer
14 items - Lung Cancer
49 items Overview Lung cancer and vitamin D - Lymphoma Cancer
22 items - Other Cancer
55 items - Ovarian Cancer
21 items - Pancreatic Cancer
55 items - Prostate Cancer
92 items Prostate Cancer and Vitamin D studies - Skin Cancer
110 items Overview Suntans melanoma and vitamin D - Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Pancreatic cancer 55 percent less likely if optimal vitamin D (vs low) – Nov 2017
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
Cancers get less Vitamin D when there is a poor Vitamin D Receptor
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Cancer is leading cause of death - Vitamin D and Receptor activators help
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
15 articles - Breast Cancer and VDR
15 articles - Colon Cancer and VDR
9 articles - Prostate Cancer and VDR
6 articles - Skin Cancer and VDR
10 articles - Note some Health problems, such as some Cancers, protect themselves by actively reducing Receptor activation
Cancer - Colon category starts with the following- Cancer - Colon category listing has
116 items along with related searches - There are
20 articles are in both Cancer - Colon and Meta-analysis categories - There are
6 articles are in both Cancer - Colon and Genetics categories - see also: Overview Cancer-Colon and vitamin D. Overview Cancer and vitamin D Overview Gut and vitamin D
- Cancer - After diagnosis category listing has
84 items along with related searches - Colorectal cancer treated by Vitamin D – 19th meta-analysis – Sept 2020
Pancreatic Cancer trials using Vitamin D and viral therapy – Nov 2018 contains the following- Pancreatic Cancer Survival 40 percent more likely if had adequate vitamin D (30 ng) – June 2016
- Pancreatic cancer 55 percent less likely if optimal vitamin D (vs low) – Nov 2017
- Pancreatic cancer risk of death reduced 19 percent by Vitamin D – meta-analysis June 2017
- Pancreatic Cancer stabilized by a woman taking 50,000 IU of vitamin D daily - 2016
Omega-3 helps
- Pancreatic Cancer is increasing – Vitamin D and Omega-3 should reduce the risk
- Severe acute pancreatitis treated in 11 ways by Omega-3 in just 7 days – RCT April 2018
- Omega-3 should help Pancreatic Cancer in 5 ways – June 2017
Other supplements of interest
- Pancreatic Cancer risk increased 24 percent for every 100 mg less of Magnesium intake – Dec 2015
- Pancreatic cancer prevention and treatment by alternates – Vitamin D, Vitamin C, Curcumin, etc – July 2018
Note: The current study ignores the importance of Vitamin D Genes to Cancer
Cancers might alter CYP24A1 gene
- Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014
- Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010
- 3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different – May 2012
- CYP24A1 gene in cancer cells may actually deactivate vitamin D – Oct 2012
Vitamin D Receptor and Cancers
Items in both categories Vitamin D Receptor and Cancer - Breast:- Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019
- After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019
- Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019
- Breast Cancer and Vitamin D review – March 2018
- Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Two chemicals increase the Vitamin D receptor and decrease the growth of breast cancer cells in the lab - March 2018
- Breast Cancer reduces receptor expression and thus block Vitamin D to the cells– July 2017
- Vitamin D receptor as a target for breast cancer therapy (abstract only) – Feb 2017
- Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016
- Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- Vitamin D receptor in breasts and breast cancer vary with race – March 2013
- Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012
- Genes breast cancer and vitamin D receptor - Sept 2010
Items in both categories Vitamin D Receptor and Cancer - Colon:
- Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020
- Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020
- Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019
- Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017
- Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
Items in both categories Vitamin D Receptor and Cancer
- How cancer is fought by Vitamin D (Ovarian this time) – Feb 2020
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Cancer is leading cause of death - Vitamin D and Receptor activators help
- A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Vitamin D receptor is essential for both normal and cancerous cells in the lab – June 2018
- Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Cancer risks and Vitamin D Receptors – association is unclear – 2017
- Vitamin D, Vitamin D Receptor and Cancer – Nov 2016
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR June 2014
- Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013
- Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
Items in both categories Vitamin D Receptor and Cancer - other:
- Blood cell cancer is associated with a 3X worse Vitamin D Receptor – June 2019
- A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019
- Endometriosis, Endometrial Cancer, and poor Vitamin D or Receptor – Aug 2018
- Thyroid Cancer rate has increased 3X in 3 decades, Vitamin D Receptor decreases, Calcium increases – Aug 2017
- Gastric Cancer 2.7 X more likely if poor Vitamin D Receptor (Chinese) – 2015
- 2X more likely to survive a form of esophageal cancer in China if have good vitamin D receptor – Feb 2017
- 2X more Thyroid Cancer malignancy if less than 15 ng of vitamin D – June 2012
- Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010
Items in both categories Vitamin D Receptor and Cancer - Skin:
- Sunlight, Vitamin D and Skin Cancer Book (3rd edition) - Sept 2020
- Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019
- Nonmelanoma Skin Cancer 2X more likely if poor Vitamin D Receptor – Oct 2017
- UVB improvements to Vitamin D receptor appear to improve melanoma survival – Oct 2017
- Skin Cancers, Vitamin D, Vitamin D Receptor and Genes – Jan 2015
- Malignant melanoma may be reduced by skin-activated vitamin D – Nov 2016
- Skin cancer 20 percent more likely with some Vitamin D receptor gene polymorphisms – Oct 2015
- Death from melanoma (without ulcers) greatly decreased if have lots of vitamin D receptors – May 2014
- Melanoma risk 2X to 4X higher if Vitamin D receptor genes had morphed – March 2014
- Vitamin D receptor may suppress skin cancer – Dec 2013
Items in both categories Vitamin D Receptor and Cancer - Prostate:
- Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019
- Prostate surgery outcomes vary with Vitamin D Receptors– May 2017
- Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017
- Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017
- High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016
- 2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013
Items in both categories Vitamin D Receptor and Cancer - Ovarian:
- How cancer is fought by Vitamin D (Ovarian this time) – Feb 2020
- Ovarian Cancer risk reduced if higher vitamin D, more UVB, or better vitamin D receptor – Nov 2018
- Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018
- Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- Ovarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013
 Download the PDF from Vitamin D Life
InterventionThe relationship between vitamin D status or supplementation and cancer outcomes has been examined in several meta-analyses. To address remaining knowledge gaps, we conducted a systematic overview and critical appraisal of pertinent meta-analyses. For meta-analyses of trials, we assessed their quality using AMSTAR-2 (A Measurement Tool to Assess Systematic Reviews), strength of associations using umbrella review methodology and credibility of evidence using GRADE (Grading of Recommendations, Assessment, Development and Evaluation) criteria. Meta-analyses of observational studies reported inverse associations of 25-hydroxyvitamin D with risk of cancer incidence and cancer mortality and, particularly for colorectal cancer, fulfilled some of Bradford-HilFs causation criteria. In meta-analyses of trials, vitamin D supplementation did not affect cancer incidence. However, we found credible evidence that vitamin D supplementation reduced total cancer mortality risk, with 5 out of 6 meta-analyses reporting a relative risk (RR) reduction of up to 16%: RR=0.84 (95% confidence interval: 0.74-0.95). The strength of the association, however, was classified as weak. This was true among meta-analyses of high, moderate and lower quality (AMSTAR-2-rated). Trials did not include large numbers of vitamin D-deficient participants, many tested relatively low doses and lacked sufficiently powered data on site- specific cancers. In conclusion, meta-analyses show that, while observational evidence indicates that low vitamin D status is associated with a higher risk of cancer outcomes, randomized trials demonstrate that vitamin D supplementation reduces total cancer mortality but not cancer incidence. However, trials with larger proportions of vitamin D-insufficient participants and longer durations of follow-up, plus adequately powered data on site-specific common cancers, would provide further insight into the evidence base
Vitamin D fights 13 cancers – review of 35 meta-analyses – Oct 2020175 visitors, last modified 06 Oct, 2020, This page is in the following categories (# of items in each category)Cancer211 Meta-analysis of Vitamin D 480 Attached files
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