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Overview Cholesterol and vitamin D

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Vitamin D + Omega-3 reduces Cholesterol and LDL - meta-analysis Feb 2024

The effects of vitamin D and omega-3 co-supplementation on lipid profile in adults: a systematic review and meta-analysis
Mohammad Zamani, Zahra Sohrabi, Ladan Aghakhani, Kimia Leilami, Saeed Nosratabadi, Zahra Namkhah, Cain Clark, Neda Haghighat, Omid Asbaghi, Fatemeh Fathi
Nutrition & Food Science https://doi.org/10.1108/NFS-11-2022-0387 PDF is behind $37 paywall

Previous research indicates that vitamin D and omega-3 co-supplementation may benefit overall health, but current evidence regarding its effects on lipid profile remains unclear. The present systematic review and meta-analysis aimed to examine the effects of vitamin D and omega-3 co-supplementation on lipid profile (total cholesterol [TC], low-density lipoprotein [LDL], triglyceride [TG] and high-density lipoprotein HDL) in adults.

In this systematic review and meta-analysis, relevant studies were obtained by searching the PubMed, Scopus and Web of Science databases (from inception to January 2022). Weighted mean differences and 95% confidence intervals were estimated via a random-effects model. Heterogeneity, sensitivity analysis and publication bias were reported using standard methods.

Pooled analysis of six randomized controlled trials (RCTs) revealed that vitamin D and omega-3 co-supplementation yielded significant reductions in TG (p = 0.631). A pooled analysis of five trials indicated a significant association between omega-3 and vitamin D treatment and reductions in TC (p = 0.001) and LDL (p = 0.001). Although, pooled analyses of omega-3 and vitamin D did not significantly affect HDL.

The findings suggest that vitamin D and omega-3 co-supplementation lowers TG, TC and LDL in adults. Future, large-scale, RCTs on various populations are needed to elucidate further beneficial effects of vitamin D and omega-3 co-supplementation on lipid profile and establish guidelines for clinical practice.

Having so-called normal cholesterol in a society where it’s normal to drop dead of a heart attack isn’t necessarily a good thing - Greger.

How Low Should You Go for Ideal Cholesterol Levels? Dr. Greger's video and transcript Sept 2021

  • "Maybe we should define an LDL cholesterol level as optimal only when it no longer causes disease. What a concept! "
  • "The majority of the adult population of the world had LDLs of about 50 mg—so that’s the true normal."

Dietary Guidelines: “Eat as Little Dietary Cholesterol as Possible” April 2023
Transcript and short video
Extensive review of many decades of literature.
Ignoring most of the recent studies funded by egg institute
He mentions eggs ==> more Calcium. wonder if Vitamin K2 would help

DrGreger category in Vitamin D Life

Cholesterol Paradigm Shift in Japan April 2015 - 100 pages

Towards a Paradigm Shift in Cholesterol Treatment. A Re-examination of the Cholesterol Issue in Japan
Ann Nutr Metab 2015;66(suppl 4):1-116 (DOI:10.1159/000381654)

 Download the PDF from Vitamin D Life

Hundreds of charts - here are just two


  • Chapter 1 Cholesterol and Mortality
  • Chapter 2 Cholesterol and Disease
  • Chapter 3 Familial Hypercholesterolemia: The Key to Solving the Cholesterol Myth
  • Chapter 4 Japan Atherosclerosis Society (JAS) Guidelines
  • Chapter 5 The Latest Edition of the 2012 JAS Guidelines Part I: The Most Important Figure and Table
  • Chapter 8 The Latest Edition of the JAS Guidelines (2012) Part IV: The Adverse Effects of Statins
  • Chapter 9 Are Statins Effective for Preventing Coronary Heart Disease in Type 2 Diabetes Mellitus in Japan, as the 2012 JAS Guidelines Recommend?
  • Chapter 10 Hypertriglyceridemia and Low Levels of High-Density Lipoprotein Cholesterol: Are They Treatment Targets?

Death rate and diseases all DECREASE as Cholesterol increased in 167 countries

in 167 countries Death rate,   infectious diseases - - -  non-communicable,   cardio - -
    All decrease as Cholesterol is increased
statistics from 167 countries
Detailed files are attached at the bottom of this page

Update Dec 2015 - a reader extracted the data from the spreadsheet

and got the resulting simple Mortality vs. cholesterol level chart

Suppressed study found that lowering Cholesterol ==> increased the chance of death.

Mercola May 2017

  • "The study,18 conducted from 1968 to 1973, included 9,423 participants between the ages of 20 and 97, making it the largest trial of its kind."
  • "For every 30-point drop in total cholesterol, there was a 22 percent increased chance of death."
  • Statins continue to be prescribed (to lower cholesterol) even though:
    "100 people need to take a statin as a primary preventive for five years in order for one or two people to avoid a heart attack, and none will actually live longer."

Vitamin D is Synthesized From Cholesterol and Found in Cholesterol-Rich Foods Masterjohn 2006


  1. Sources of Vitamin D: Sunlight
  2. Sources of Vitamin D: Cholesterol-Rich Foods
  3. Are Plants and Irradiated Mushrooms a Source of Vitamin D?
  4. The Many Functions of Vitamin D: More Than Just Calcium
  5. Do Cholesterol-Lowering Statins Inhibit Vitamin D Synthesis?
  6. Requirements: How Much Vitamin D Do We Need?
  7. Toxicity: How Much is Too Much?
  8. Make Sure to Get Your Vitamin A
  9. Without Cholesterol, There Is No Vitamin D
      Newer article by the same author

From Seafood to Sunshine: A New Understanding of Vitamin D Safety Dec 2006

Less cholesterol in the diet resulted in less vitamin D in the blood (in mice) – Feb 2016


The Relation of Cholesterol to Vitamin D - 1927

$10.6 billion spent in 2009 in the US on cholesterol lowering foods

Vitamin D and Cholesterol book by Dr, Grimes reviewed at Vitamin D Life

Quote on Cholesterol and vitamin D from Vitamin D Council

Our most important hormones depend upon adequate reserves of cholesterol for their production, and nowhere is this more important than as the precursor substance for the synthesis of Vitamin D, known also as calcitriol. Researchers in this field are sufficiently concerned from the results of their studies to pronounce that we are in the midst of an epidemic of vitamin D deficiency of immense proportion ~ Duane Graveline MD MPH, former NASA Astronaut, former USAF flight surgeon, and retired family doctor.'

There is a lot of concern that decreasing cholesterol is the ~~#F00:WRONG thing to do//www.thincs.org

High cholesterol is Good

Study from Israel of heart failure patients Dr. Grimes 2018

Decrease in Cholesterol during the last 30 years CDC

from http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5837a9.htm

What Is the Connection Between Vitamin D and Cholesterol? WiseGeek

Vitamin D and cholesterol are closely linked, both in bodily processes as well as in nutrition. One important role of cholesterol is that is plays a vital part in the synthesis of vitamin D in the body. In the diet, vitamin D is found in foods that have high levels of cholesterol, such as cod liver oil and eggs. Studies have been done to see if there is a correlation between the levels of vitamin D a person has and their cholesterol levels, but the results are inconclusive.

There is a close connection in the body between Vitamin D and cholesterol. One of the biggest sources of vitamin D for individuals is contact with sunlight; upon exposure to sunlight, the body can synthesize its own vitamin D. Cholesterol is involved in the process of synthesizing vitamin D from sunlight, and without cholesterol, vitamin D synthesis would be impossible.

Dietary sources also provide a connection between Vitamin D and cholesterol. There is typically a correlation between foods that are rich in vitamin D and cholesterol — that being, foods that are high in vitamin D are often also high in cholesterol. For example, cod liver oil is an excellent source of vitamin D, but it is also very high in cholesterol. Other foods that are high in vitamin D are lard and eggs, two foods that are notorious for being high in cholesterol.

Many scientists are researching a possible correlation between an individual’s levels of vitamin D and cholesterol. High cholesterol, also known as hypercholesterolemia, affects many individuals and increases o! one’s risk for heart disease and stroke. It is important to keep cholesterol levels under control in order to stay healthy, which is why many are searching to see if there is a correlation between these two nutrients.

Studies seem to show that individuals with higher levels of vitamin D have lower cholesterol levels and are generally healthier overall than individuals with low levels of vitamin D. Yet; these studies do not show a direct correlation between the two. For example, vitamin D is involved in calcium absorption, so having higher levels of vitamin D may mean that more calcium is being absorbed and that calcium is the nutrient actually causing an effect on cholesterol. Individuals with high levels of vitamin D also may have these high levels because they spend a lot of time outdoors in the sunlight doing physical activities, which is one way to reduce cholesterol. Although studies indicate that individuals with high levels of vitamin D have lower cholesterol, it is unknown whether or not this result is directly related to vitamin D.

There are many benefits of vitamin D, such as helping to regulate levels of calcium, preventing osteoporosis, and improving moods. If one chooses to take vitamin D supplements to help lower cholesterol or to gain any of the many benefits of this nutrient, they should choose their supplements carefully. Two popular types of vitamin D are vitamin D2 and vitamin D3. Vitamin D3 is naturally occurring and easy for the body to process. Vitamin D2 is difficult for the body to process and may result in toxicity. Vitamin D3 is the safer supplement to choose from, and daily recommended dosages should always be followed.

Written by B. Koch, Edited by Jenn Webb, Last Modified: 04 December 2010

Very low LDL increases the risk of stroke by 2X - April 2019

Items in both categories, Cholesterol, and Magnesium, are listed here:

See also at Vitamin D Life

Cholesterol category in Vitamin D Life starts with the following

51 items below in the Vitamin D Life category = Cholesterol

see also Overview Hypertension and Vitamin D
Search HLD OR LDL   Overview Cardiovascular and vitamin D
Overview Cholesterol and vitamin D

See also on the web

blood pressure- cholesterol - diabetes  venn diagram

The gene which lowers cholesterol levels results in 88% less heart disease

Proof that Lifelong Cholesterol Reduction Prevents Heart Disease Greger video Feb 2020

  • " About 1 in 40 African Americans have a mutation that drops their LDL cholesterol from around 130 down toward more optimal levels. Now, this group didn’t eat healthily to get achieve that drop. It’s just in their genes. More than half had high blood pressure, and there were a lot of smokers and diabetics in the group, yet those with genetically low LDL levels still had a significant reduction in the incidence of coronary heart disease even in the presence of all those other risk factors. How significant? How much less heart disease? A remarkable 88 percent of heart disease was simply gone."

Overview Cholesterol and vitamin D        
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Attached files

ID Name Comment Uploaded Size Downloads
10895 Heart Failure survival vs LDL.jpg admin 23 Nov, 2018 13.21 Kb 5459
7177 CHD trending downward.jpg admin 14 Oct, 2016 43.29 Kb 11589
7176 Cholesterol age 56-65.jpg admin 14 Oct, 2016 18.98 Kb 11328
7175 Cholesterol age 30-39.jpg admin 14 Oct, 2016 20.31 Kb 11456
6236 Cholesterol cleaned up.png admin 11 Dec, 2015 28.15 Kb 17316
5473 Cholesterol Mortality vs time.jpg admin 19 May, 2015 33.83 Kb 19840
5472 Cholesterol Mortality.jpg admin 19 May, 2015 66.11 Kb 19470
5471 Cholesterol May 2015.pdf admin 19 May, 2015 1.52 Mb 3092
155 cholesterol-health spreadsheet.xls admin 19 Aug, 2010 1.85 Mb 8706
154 Cholesterol data Sept 2009.doc admin 19 Aug, 2010 1.35 Mb 4663