53 items in category Iron and Vitamin D

See also Iron deficiency is a cause of Vitamin D deficiency

Summary

• Ferrus sulfate is the most common, lowest cost, and worst form of supplementation
• Heme iron polypeptide appears to be 23X better than Ferrous fumarate
• Ferrochel better in many ways than ferrous sulfate

Several items clipped from web

Iron Supplement in WikiPedia

Iron can be supplemented by the oral route using various pharmacological forms, such as iron(II) sulfate (this is the most common and cheapest salt, e.g. Feratab, Fer-Iron, Slow-FE,…) and in complex with gluconate, dextran, carbonyl iron, and other salts. Sometimes ascorbic acid is added for better absorption.

Heme iron polypeptide (HIP) (e.g. Proferrin ES and Proferrin Forte) can be used when regular iron supplements such as ferrous sulfate or ferrous fumarate are not tolerated or absorbed. A clinical study demonstrated that HIP increased serum iron levels 23 times greater than ferrous fumarate on a milligram-per-milligram basis. {Click here for details or studies and purchase also patented}

Another alternative is ferrous glycine sulfate or ferroglycine sulfate, has less gastrointestinal side-effects than standard preparations such as iron fumarate, It is unusual among oral preparations of iron supplements in that the iron in this preparation has very high oral bio-availability esp in the liquid version (e.g. Hemfer by Alkem).This option should be evaluated before resorting to parenteral therapy. It is especially useful in iron deficiency anemia associated with autoimmune gastritis and Helicobacter pylori gastritis, where it generally has satisfactory effect.

Since iron stores in the body are generally depleted, and there is a limit to what the body can process (about 2–6 mg/kg of body mass per day; i.e. for a 100 kg/220 lb man this is equal to a maximum dose of 200–600 mg/per day) without iron poisoning, this is a chronic therapy which may take 3–6 months.

Due to the frequent intolerance of oral iron and the slow improvement, parenteral iron is recommended in many indications

Click here for more on HEP Iron at Vitamin D Life

A Patient’s Guide to Oral Iron Supplements Anemia.org 2008

Iron Supplement	Tablet Size	Elemental Iron
Ferrous fumarate	325 mg	108 mg
Ferrous sulfate	325 mg	65 mg
Ferrous gluconate	325 mg	35 mg

• Adults will usually require a dose of 60-200 mg of elemental iron daily, depending on the severity of the anemia.2
  Since the amount of iron absorbed decreases as doses get larger, most people should take their daily iron supplement in two or three equally spaced doses.
• Iron supplements are available in regular tablets and capsules, liquid, drops, and coated or extended-release tablets and capsules.

What are The Best Iron Supplements for Women Livestrong June 2011

• Discusses: Floradix. Nature Made, Feosol, Fergon

Amazon Top rated Iron

• Heme-iron polypeptide (HIP) apprears to be better absorbed and tolerated than ferrus sulfate
• polysaccharide-iron complex (PIC) is tolerated better than sulfate
• Iron protein succinylate nicely just dissolved in the intestine, rather than the stomach – less gastric irritation and more iron into the blood (LEF sells it)

Consumer Labs review of Iron supplements Subscription and free 5 day trial

• cost of 25 mg varied from 2 cents to $2.00 (Floradex with Herbs)
• Updated review Dec 2018

Iron supplements for fatigue Science-Based Medicine

• Comment by one person: Vitamin C – its role in aiding iron absorption is with dietary iron, not as useful for iron supplements.

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Enhancers of iron absorption: ascorbic acid and other organic acids. PubMed 2005

• lots of excellent information in the abstract

Ferrochel better ferrous sulfate during pregnancy PubMed 2001

• 2X more taken the treatment adequately
• 2X fewer still had Iron deficiency
• none of Ferrochel patients had taste problems vs 29% of ferrous sulfate
• Ferrochel had only 15 mg of Iron vs ferrous sulfate had 40 mg of Iron

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Suppression of Iron-Regulatory Hepcidin by Vitamin D.

J Am Soc Nephrol. 2013 Nov 7. [Epub ahead of print]
Bacchetta J, Zaritsky JJ, Sea JL, Chun RF, Lisse TS, Zavala K, Nayak A, Wesseling-Perry K, Westerman M, Hollis BW, Salusky IB, Hewison M.
Department of Orthopaedic Surgery, UCLA Orthopaedic Hospital, and.

The antibacterial protein hepcidin regulates the absorption, tissue distribution, and extracellular concentration of iron by suppressing ferroportin-mediated export of cellular iron. In CKD, elevated hepcidin and vitamin D deficiency are associated with anemia. Therefore, we explored a possible role for vitamin D in iron homeostasis. Treatment of cultured hepatocytes or monocytes with prohormone 25-hydroxyvitamin D or active 1,25-dihydroxyvitamin D decreased expression of hepcidin mRNA by 0.5-fold, contrasting the stimulatory effect of 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D on related antibacterial proteins such as cathelicidin. Promoter-reporter and chromatin immunoprecipitation analyses indicated that direct transcriptional suppression of hepcidin gene (HAMP) expression mediated by 1,25-dihydroxyvitamin D binding to the vitamin D receptor caused the decrease in hepcidin mRNA levels. Suppression of HAMP expression was associated with a concomitant increase in expression of the cellular target for hepcidin, ferroportin protein, and decreased expression of the intracellular iron marker ferritin. In a pilot study with healthy volunteers, supplementation with a single oral dose of vitamin D (100,000 IU vitamin D2) increased serum levels of 25D-hydroxyvitamin D from 27±2 ng/ml before supplementation to 44±3 ng/ml after supplementation (P<0.001). This response was associated with a 34% decrease in circulating levels of hepcidin within 24 hours of vitamin D supplementation (P<0.05).
These data show that vitamin D is a potent regulator of the hepcidin-ferroportin axis in humans and highlight a potential new strategy for the management of anemia in patients with low vitamin D and/or CKD.

PMID: 24204002
Wikipedia
Hepcidin is a peptide hormone produced by the liver.
It was discovered in 2000, and appears to be the master regulator of iron homeostasis in humans and other mammals

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See also Vitamin D Life

• Iron deficiency is a cause of Vitamin D deficiency also reviews other forms of Iron
• Anemia 1.9X more likely in white children having lowish vitamin D – Jan 2014
• Iron and Vitamin D deficiencies are synergistic - April 2015
• Iron supplementation with much less nausea (Polysaccharide and heme forms) – Jan 2016
• Anemia in pregnant teens 7X more likely if low vitamin D – April 2015
• All items in category Iron and Vitamin D 53 items

Diseases associated with

Low iron (menstruating)	High iron (males)
Anemia	Anemia of chronic disease
Fibromyalgia	Premature aging
Inflammatory bowel disease	Atherosclerosis
Hypothyroidism	Anorexia
Depression / anxiety	Grave's disease
Attention deficit hyperactivity disorder	Heart arrhythmia
Parkinson's disease	Cancer
Neurodegenerative conditions	Sideroblastic anemia
Celiac disease	Nonalcoholic fatty liver disease (NAFLD). Excess dietary fructose is a primary initiator of NAFLD, but high iron is another culprit that triggers disease progression
Restless leg syndrome	Liver damage and liver disease
Hair loss	Still's disease
Muscle weakness, decline in motor skills	Hemochromatosis
Mental changes and memory loss	Hemophagocytic syndrome

• Serum Ferritin and GGT — Two Potent Health Indicators You Need to Know Sept 2017
  "Iron Overload Is More Common Than Iron Deficiency"
  "In recent years, scientists have discovered GGT is highly interactive with iron, and when both your serum ferritin and GGT are high, you are at significantly increased risk of chronic health problems, because then you have a combination of free iron, which is highly toxic, and iron storage to keep that toxicity going"

See also web

• The Association between Iron and Vitamin D Status in Female Elite Athletes Jan 2018
  • Those deficient in Iron were 1.75 X at higher risk of also being deficient in Vitamin D, free PDF online
• Feosol Amazon - appears to be the lowest cost
  • 6 mg of Hemi + 22mg PIC (regular) $16 for 30 caplets - similar to other Iron supplement may cause intestinal problems
• Proferrin has a great discount sample offer as of Aug 2013: $10 for 14 tablets of 12 mg
  • 23X more bio-available than ferrous fumarate
• US National Institute of Health - Iron snips as of April 2015
  • Dietary iron has two main forms: heme and nonheme
  • Recommended Dietary Allowances for Iron (just infant and middle age)
• Heme Iron Dr. Greger 10 videos
  • Comcerned about long-term supplementation
  • "Once ingested and absorbed, the body has no mechanism to remove excess iron"
• Iron and vitamin D deficiency in children living in Western-Europe Oct 2017
  PHD dissertation, full text online
  "Secondly, we describe prevalence rates of ID and VDD in healthy young children, moderately preterm infants, and in children with inflammatory bowel disease or diabetes type 1."
  "Furthermore, we also describe associations with ID and VDD that clinicians can use to detect patients at risk for deficiency."

See also Hepcidin

• VITAMIN D AND IRON, THE CONNECTION YOU NEVER KNEW ABOUT April 2017
  Kerri Knox April 2017 "VITAMIN D AND IRON ARE COFACTORS OF EACH OTHER, Case in point is our discussion here. Interestingly, the relationship between Vitamin D and Iron possibly runs both ways, as the research suggests that each are cofactors for each other. If you don’t have enough vitamin D, you can’t absorb iron properly; if you don’t have enough iron, you can’t have adequate vitamin D levels."

• Suppression of Iron-Regulatory Hepcidin by Vitamin D Nov 2013
  Free PDF on-line with many charts. 100,000 IU of vitamin D2 decreased Hepcidin level by 34% in 24 hours
• The role of vitamin D in regulating the iron-hepcidin-ferroportin axis in monocytes March 2014
  "Chronic kidney disease affects 40% of adults aged 65 and older. Anemia of CKD is present in 30% of patients with CKD and is associated with increased cardiovascular risk, decreased quality of life, and increased mortality. Hepcidin-25 (hepcidin), the key iron regulating hormone, prevents iron egress from macrophages and thus prevents normal recycling of the iron needed to support erythropoiesis. Hepcidin levels are increased in adults and children with CKD. Vitamin D insufficiency is highly prevalent in CKD and is associated with erythropoietin hyporesponsiveness. Recently, hepcidin levels were found to be inversely correlated with vitamin D status in CKD. " Free PDF online
• Molecular study of hepcidin in chronic hepatitis C genotype 4 patients treated with pegylated interferon/ribavirin with vitamin D 2016
  2,000 IU Vitamin D daily ( a small amount), PDF online, does not seem to indicate % of non-responders

• High-dose vitamin D3 reduces circulating hepcidin concentrations: A pilot, randomized, double-blind, placebo-controlled trial in healthy adults Aug 2017
  • 250,000 IU of vitamin D significantly reduced hepcidin in 1 week.
  •  Download the PDF from Vitamin D Life
• Search Vitamin D Life for hepcidin 106 items as of July 2020
• Search Vitamin D Life for ANEMIA 1470 items as of July 2020
• Search Vitamin D Life for ANEMIA & AFRICAN-AMERICAN 211 items as of Julu 2020
• Overview Sickle Cell and Vitamin D
• Low vitamin D - anemia 2.2X more likely (no surprise) – meta-analysis Aug 2015
• Sickle Cell children need more than 7,000 IU of vitamin D daily – May 2015 - adding Iron would probably help

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Age	Male	Female	Pregnancy	Lactation
Birth to 6 months	0.27 mg*	0.27 mg*
19–50 years	8 mg	18 mg	27 mg	9 mg

The only difference between chlorophyll and hemoglobin is
   Magnesium vs Iron in the center

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Iron Deficiency symptoms

Top10HomeRemedies

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Iron Deficiency estimated by Smartphone photos - Nov 2018

Smartphone app for non-invasive detection of anemia using only patient-sourced photos

This appears to be the 3rd smartphone application to detect anemia

Did not notice if any of these are ready to be used by the general public

Doubt that this, and similar tests which eliminate use of doctors, has been accepted by the FDA

 Download the PDF from Vitamin D Life

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Anemia while pregnant

Aug 2017

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Mercola May 2017

Why Managing Your Iron Level Is Crucial to Your Health Mercola May 2017

• Not too much or too little. includes interview and transcript
  "I believe it can be every bit as dangerous to your health as vitamin D deficiency." Mercola
• Videos discussing the importance of many blood tests, including Ferretin (Iron) Sept 2018
  Test annually to confirm that you do not have too little or too much

Iron: Not too much and not too little - Mercola Aug 2020

Your Iron Levels Could Be a Key to Slow Aging and Long Life

• "... an excessive amount of iron is more common than having a deficiency."
• "In one study, researchers estimated 40% to 70% of people with the defective genes will eventually have iron overload."