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Allergy - Overview

Did you know?
  • Low vitamin D is strongly associated with most types of allergies
  • There is a 5 to 10 times higher risk of food allergy with low vitamin D
  • People living in cities or having dark skins generally have low vit D and more allergies
  • There is Overwhelming Evidence that vitamin D reduces allergies
          (More Allergy info below)

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Allergies and Vitamin D

Food Allergy

Items in both categories Autoimmune and Infant/Child are listed here:

Food Allergy 5X more likely if low vitamin D – Oct 2014

The link between serum vitamin D level, sensitization to food allergens, and the severity of atopic dermatitis in infancy.
J Pediatr. 2014 Oct;165(4):849-54.e1. doi: 10.1016/j.jpeds.2014.06.058. Epub 2014 Aug 6.
Baek JH1, Shin YH1, Chung IH1, Kim HJ1, Yoo EG1, Yoon JW2, Jee HM1, Chang YE3, Han MY4.
1Department of Pediatrics, CHA University School of Medicine, Seongnam, Korea.
2Myongji General Hospital, Goyang, Korea.
3Department of Food and Nutrition Services, CHA Bundang Medical Center, Seongnam, Korea.
4Department of Pediatrics, CHA University School of Medicine, Seongnam, Korea. Electronic address: drmesh at gmail.com.

Vitamin D Life

Vitamin D deficiency definition varies
This article is similar to many countries: < 20 ng
The lower the vitamin D level, the more allergies each child had

OBJECTIVE: To investigate the association between serum vitamin D levels, sensitization to food allergens, and the severity of atopic dermatitis in infants.

STUDY DESIGN: We investigated serum 25-hydroxyvitamin D (25[OH]D) and specific immunoglobulin E levels to common or suspected food allergens in 226 infants with atopic dermatitis or food allergy. The severity of atopic dermatitis by the Scoring Atopic Dermatitis index and amount of vitamin D intake was measured in subcohort children. Sensitization to food allergen was categorized by the number (non-, mono-, and poly-) of sensitized allergens and the degree (undetected-, low-, and high-level) of sensitization.

RESULTS: Significant differences in 25(OH)D levels were found between groups on number (P = .006) and degree (P = .005) of food sensitization. The polysensitization group had significantly lower levels of 25(OH)D than the nonsensitization (P = .001) and monosensitization (P = .023) group. High-level sensitization group had significantly lower 25(OH)D levels compared with undetected (P = .005) and low-level (P = .009) sensitization group. Vitamin D deficiency increased the risk of

  • sensitization to food allergens (OR 5.0; 95% CI 1.8-14.1), especially to
  • milk (OR 10.4; 95% CI 3.3-32.7) and
  • wheat (OR 4.2; 95% CI 1.1-15.8).

In addition, the9% of US adults b elieve they have a food alllery Scoring Atopic Dermatitis index was independently related to 25(OH)D levels after adjusting for the level of sensitization (adjusted R(2) = 0.112, P = .031).

CONCLUSIONS: Our results suggest that vitamin D deficiency increases the risk of sensitization to food allergens and that atopic dermatitis may be more severe in infants with vitamin D deficiency.


Copyright © 2014 Elsevier Inc. All rights reserved.

PMID: 25108543
 Download the PDF from Vitamin D Life.

19% of US adults now believe that they have a food allergy - 2019

Prevalence and Severity of Food Allergies Among US Adults - JAMA
 Download the PDF from Vitamin D Life
Seems that they do not consdier gluten intolerance to be a food allergy

10X more likely to have multiple food allergies if low vitamin D - Sept 2013

1 page item had the following results

Vitamin D levels and food and environmental allergies in the United States - May 2011

Results from the National Health and Nutrition Examination Survey 2005-2006
The Journal of Allergy and Clinical Immunology, Volume 127, Issue 5 , Pages 1195-1202, May 2011
Shimi Sharief, MD; Sunit Jariwala, MD; Juhi Kumar, MD, MPH; Paul Muntner, PhD; Michal L. Melamed, MD,

Background: Previous research supports a possible link between low vitamin D levels and atopic disease.
However, the association between low vitamin D levels and total and allergen-specific IgE levels has not been studied.

Objective: We sought to test the association between serum 25-hydroxyvitamin D (25[OH]D) deficiency (<15 ng/mL) and insufficiency (15-29 ng/mL) and allergic sensitization measured by serum IgE levels in a US nationally representative sample of 3136 children and adolescents and 3454 adults in the National Health and Nutrition Examination Survey 2005-2006.

Methods: The association of 25(OH)D deficiency with 17 different allergens was assessed after adjustment for potential confounders, including age; sex; race/ethnicity; obesity, low socioeconomic status; frequency of milk intake; daily hours spent watching television, playing videogames, or using a computer; serum cotinine levels; and vitamin D supplement use.

Results: In children and adolescents allergic sensitization to 11 of 17 allergens was more common in those with 25(OH)D deficiency. Compared with sufficient vitamin D levels of greater than 30 ng/mL, after multivariate adjustment, 25(OH)D levels of less than 15 ng/mL were associated with

  • peanut (odds ratio [OR], 2.39; 95% CI, 1.29-4.45),
  • ragweed (OR, 1.83; 95% CI, 1.20-2.80), and
  • oak (OR, 4.75; 95% CI, 1.53-4.94) allergies (P < .01 for all).

Eight other allergens were associated with 25(OH)D deficiency, with P values of less than .05 but greater than .01.
There were no consistent associations seen between 25(OH)D levels and allergic sensitization in adults.

Conclusion: Vitamin D deficiency is associated with higher levels of IgE sensitization in children and adolescents.
Further research is needed to confirm these findings.

Food allergies are associated with both Vitamin D and Vitamin D genes - 2018

Cellular and molecular mechanisms of vitamin D in food allergy
Journal of cellular and molecular medicine, DOI:10.1111/jcmm.13607
Ashlyn Poole, Yong Song, +2 authors Guicheng Brad Zhang

Food allergies are becoming increasingly prevalent, especially in young children. Epidemiological evidence from the past decade suggests a role of vitamin D in food allergy pathogenesis. Links have been made between variations in sunlight exposure, latitude, birth season and vitamin D status with food allergy risk. Despite the heightened interest in vitamin D in food allergies, it remains unclear by which exact mechanism(s) it acts. An understanding of the roles vitamin D plays within the immune system at the cellular and genetic levels, as well as the interplay between the microbiome and vitamin D, will provide insight into the importance of the vitamin in food allergies. Here, we discuss the effect of vitamin D on immune cell maturation, differentiation and function; microbiome; genetic and epigenetic regulation (eg DNA methylation); and how these processes are implicated in food allergies.
 Download the PDF from Vitamin D Life

RTI 36% more likely if low Vitamin D during pregnancy - meta-analysis - May 2018

Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta-analysis of observational studies.
Pediatric allergy and immunology, DOI:10.1111/pai.12876
not on sci-hub as of Jan 2019 but can be read in DeepDive
Rosa M Pacheco-González, L Garcia-Marcos, Eva Morales

BACKGROUND: Prenatal vitamin D status may influence offspring's respiratory and allergic outcomes; however, evidence is inconclusive. A systematic review and meta-analysis were conducted on the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or cord blood at birth with the risk of offspring's respiratory and allergic conditions.

METHODS: Two independent researchers conducted systematic searches for observational studies published until May 2017 using defined keywords on vitamin D and health outcomes, including respiratory tract infections (RTIs), wheeze, asthma, atopic eczema, allergic rhinitis, allergic sensitization, and lung function. Random-effects meta-analyses were conducted.

RESULTS: A total of 34 from 547 retrieved articles were included. Increased prenatal exposure to 25(OH)D was inversely associated with risk of RTIs. Comparing the highest with the lowest category of 25(OH)D levels, the pooled odds ratio was 0.64 (95% CI 0.47, 0.87). A positive borderline association was found for lung function at school age (FEV1 z-score coefficient 0.07, 95% CI -0.01, 0.15). No associations were found for wheeze, asthma, atopic eczema, allergic rhinitis, and allergic sensitization.

CONCLUSION: The introduction of public health measures to tackle vitamin D status in pregnancy may reduce the burden of RTIs in offspring. Current evidence does not support an impact on asthma and allergy.

Gut microbiota, probiotics, and vitamin D - May 2011

:next term Interrelated exposures influencing allergy, asthma, and obesity?
Journal of Allergy and Clinical Immunology
Volume 127, Issue 5, May 2011, Pages 1087-1094; doi:10.1016/j.jaci.2011.02.015
Ngoc P. Ly MD, MPHa, Corresponding Author Contact Information, E-mail The Corresponding Author, Augusto Litonjua MD, MPHb, Diane R. Gold MD, MPHb and Juan C. Celedón MD, DrPHc
a Division of Pediatric Pulmonary Medicine, Department of Pediatrics, University of California San Francisco, San Francisco, Calif
b Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass
c Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pa

Current evidence supports a role for gut colonization in promoting and maintaining a balanced immune response in early life. An altered or less diverse gut microbiota composition has been associated with atopic diseases, obesity, or both. Moreover, certain gut microbial strains have been shown to inhibit or attenuate immune responses associated with chronic inflammation in experimental models. However, there has been no fully adequate longitudinal study of the relation between the neonatal gut microbiota and the development of allergic diseases (eg, atopic asthma) and obesity. The emergence of promising experimental studies has led to several clinical trials of probiotics (live bacteria given orally that allow for intestinal colonization) in human subjects. Probiotic trials thus far have failed to show a consistent preventive or therapeutic effect on asthma or obesity. Previous trials of probiotics have been limited by small sample size, short duration of follow-up, or lack of state-of-the art analyses of the gut microbiota. Finally, there is emerging evidence that the vitamin D pathway might be important in gut homeostasis and in signaling between the microbiota and the host. Given the complexity of the gut micriobiota, additional research is needed before we can confidently establish whether its manipulation in early life can prevent or treat asthma, obesity, or both.

PDF is at the bottom of this page

Food allergies in children 40 % more likely in urban areas (which have less vitamin D) – Sept 2012

Geographic Variability of Childhood Food Allergy in the United States
CLIN PEDIATR September 2012 vol. 51 no. 9 856-861
Ruchi S. Gupta, MD, MPH1,2; Elizabeth E. Springston, BA1; Bridget Smith, PhD3,4; Manoj R. Warrier, MD5,6; Jacqueline Pongracic, MD1,2; Jane L. Holl, MD, MPH1
1 Northwestern University Feinberg School of Medicine, Chicago, IL, USA
2 Children’s Memorial Hospital, Chicago, IL, USA
3 Loyola Stritch School of Medicine, Maywood, IL, USA
4 Edward Hines Jr VA Hospital, Hines, IL, USA
5 Saint Louis University School of Medicine, Saint Louis, MO, USA
6 Allergy, Asthma and Sinus Care Center, Saint Louis, MO, USA
Ruchi S. Gupta, Children’s Memorial Hospital, 2300 Children’s Plaza, Box 157, Chicago, IL 60640, USA Email: rugupta at childrensmemorial.org

Objective The aim of this study was to describe the distribution of childhood food allergy in the United States.

Methods A randomized survey was administered electronically from June 2009 to February 2010 to adults in US households with at least 1 child younger than 18 years. Data were analyzed as weighted proportions to estimate prevalence and severity of food allergy by geographic location. Multiple logistic regression models were constructed to estimate the association between geographic location and food allergy.

Results Data were analyzed for 38 465 children. Increasing population density corresponded with increasing prevalence, from 6.2% in rural areas (95% confidence interval [CI] = 5.6-6.8) to 9.8% in urban centers (95% CI = 8.6-11.0).

Odds of food allergy were graded, with odds in urban versus rural areas highest (odds ratio OR = 1.7, 95% CI = 1.5-2.0), followed by metropolitan versus rural areas (OR = 1.4, 95% CI = 1.2-1.5), and so on. Significance remained after adjusting for race/ethnicity, gender, age, household income, and latitude.

Conclusions An association between urban/rural status and food allergy prevalence was observed.

See also web

  • Vitamin D3 and Allergies from VitaminD3Blog March 2011
    • Mentions several articles and has video of Dr. Daniel A. Searing: Vitamin D Deficiency Linked to Allergies, Asthma in Children
  • 5 Ways Americans' Allergies Are Getting Worse Heartland Time Magazine May 2011 - based on Qwest study
    • Overall allergy rates up 6% in 4 years
    • ragweed up 15%
  • Study: Living With Pets May Protect Infants From Allergies Heartland Time June 2011
    • Perhaps kids with pets are outdoors more, and thus have higher levels of vitamin d
    • Additional possibility: cat fur (like most animal fur and feathers) has vitamin D - probably some will rub off when petting
  • Longitudinal trajectory of vitamin D status from birth to early childhood in the development of food sensitization. June 2013
    Risk of food sensitivity increased by 2X if consistently low vitamin D levels
  • Allergy in Children in Hand Versus Machine Dishwashing Pediatrics Feb 2015 (nothing about vitamin D)
    2X less likely to have food allergy if dishes were washed by hand, not machine
    lower likelihood of eczema (23% vs. 38%) and not other allergy-related symptoms like asthma,
    this adds to the “hygiene hypothesis,” which includes having pets, eating fish and living on a farm
    researchers note that overcrowded housing, low socioeconomic status and immigration status can also be linked to fewer allergies
  • World Allergy Organization decided that ZERO vitamin D should be given during pregnancy or to infants or children - 2016
  • Food allergy 2.2X MORE likely if high vitamin D - 2016 disagrees with all previous studies
    Seasonal Allergies in Austin, Texas - nothing about Vitamin D
  • Why the World Is Becoming More Allergic to Food BBC Sept 2020
    • "Food allergy now affects about 7% of children in the UK and 9% of those in Australia, for example. "
    • "For example, there was a five-fold increase in peanut allergies in the UK between 1995 and 2016."
    • "Migrants appear to show a higher prevalence of asthma and food allergy in their adopted country"
      • Note: Migrants tend to have darker skins and are going to countries far from Equator
    • Vitamin D deficiency is mentioned as a strong posibility
    • One of their references is on Vitamin D Life
      • ((Hypothesis: Allergic diseases have increased because of decreased vitamin D – Oct 2014)
Allergy - Overview        
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Attached files

ID Name Comment Uploaded Size Downloads
12521 Food allergies.jpg admin 22 Aug, 2019 15:37 50.26 Kb 1943
12520 Severity of Food Allergies Among US - 2019.pdf admin 22 Aug, 2019 15:33 344.77 Kb 337
11198 RTI Meta.jpg admin 13 Jan, 2019 20:13 32.17 Kb 2927
11197 Food allergies and Vitamin D and genes.pdf PDF 2018 admin 13 Jan, 2019 19:57 235.07 Kb 354
11064 Seasonal allergies.jpg admin 18 Dec, 2018 17:25 34.00 Kb 3024
7821 Food allergy 2.2X MORE likely if high vitamin D - 2016.pdf PDF 2016 admin 11 Mar, 2017 02:50 231.64 Kb 893
7741 WAO Allergy.pdf PDF 2016 admin 20 Feb, 2017 22:50 562.05 Kb 1020
4962 Food allergy.pdf PDF 2014 admin 22 Jan, 2015 14:21 606.87 Kb 2115
4961 Food allergy appendix.jpg admin 22 Jan, 2015 14:19 20.47 Kb 10014
4960 Food F4B.jpg admin 22 Jan, 2015 14:19 22.58 Kb 10470
3108 Allergy association.jpg 2013 admin 08 Oct, 2013 13:22 44.74 Kb 11665
1215 Gut microbiota, probiotic-2011.pdf gut PDF admin 06 Apr, 2012 03:12 148.37 Kb 4261
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