3X less risk of Atherosclerotic Disease if good level of Vitamin D (Japan) – June 2023

The Association between Atherosclerotic Disease Risk Factors and Serum 25-Hydroxyvitamin D Concentration in Japanese Subjects

J Nutr Sci Vitaminol (Tokyo) . 2023;69(3):176-183. doi: 10.3177/jnsv.69.176.
Akane Yasuoka 1, Naoko Tsugawa 2 3, Chihiro Ura 4, Honami Ogasawara 3, Kiyoshi Tanaka 5, Kei Mizuno 6 7 8 9, Yasuyoshi Watanabe 6 7 8 10, Akiko Kuwabara 1 11

Association to physical activity is important

Risk of Atherosclerotic Disease

Recent studies have described that vitamin D deficiency/insufficiency is associated with hypertension, insulin resistance, and dyslipidemia, which are major components of metabolic syndrome causing atherosclerosis. Therefore, we investigated the relationship between serum 25-hydroxyvitamin D [25(OH)D] concentration and atherosclerotic disease risk factors in healthy Japanese adults. In the present cross-sectional study, 1,177 subjects (348 males and 829 females) aged 20-72 y living in Japan (34.7-35.0ºN) were evaluated for vitamin D status by measuring serum 25(OH)D concentration.
Atherosclerotic disease risk factors were defined as the presence of two or more of the following three risk factors:

• high blood pressure,
• dyslipidemia, and
• hyperglycemia.

The percentages of vitamin D deficient and insufficient subjects were 33% and 46% in males and 59% and 32% in females, respectively. Subjects with atherosclerotic disease risk factors were significantly older and had higher BMI than those without it in both sexes. Male subjects with atherosclerotic disease risk factors had significantly lower physical activity and serum 25(OH)D concentration than those without it.
In a logistic regression analysis adjusted for confounding factors, serum 25(OH)D concentration showed a significant inverse association with risk factors of atherosclerotic disease in males (OR=0.951, 95%CI: 0.906-0.998), but not in females. A covariance structure analysis also suggested that serum 25(OH)D level has a direct association with risk factors of atherosclerotic disease. In conclusion, we have demonstrated that low serum 25(OH)D level is a significant factor for increased atherosclerotic disease risk factors in males.
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Vitamin D Life – Hypertension category contains

see also
Overview Overview Hypertension and Vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
Some interesting Hypertension studies

• Hypertension risk decreased 10X by increasing vitamin D levels to more than 40 ng – Nov 2017
• COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
• Magnesium reduces hypertension - FDA allows claim - Jan 2022
• Drug-resistant hypertension 3.5 X more likely if low vitamin D – March 2020
• High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis May 2019
• Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
• Hypertension is associated with low vitamin D in some groups – meta-analysis April 2015
• Off Topic – Hypertension in 42 percent of adults (new definition: 130 mm Hg) – Feb 2018
  • Men aged 40-59 59%, age >60 75%: National Health and Nutrition Examination Survey, 2017–2018

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