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Alzheimer's 3X higher risk in countries with high meat consumption - 2016


Using Multicountry Ecological and Observational Studies to Determine Dietary Risk Factors for Alzheimer's Disease

J Am Coll Nutr. 2016 Jul;35(5):476-89. doi: 10.1080/07315724.2016.1161566.
William B Grant 1

Chart of 10 countries

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Rates of Alzheimer's disease (AD) are rising worldwide. The most important risk factors seem to be linked to diet. For example, when Japan made the nutrition transition from the traditional Japanese diet to the Western diet, AD rates rose from 1% in 1985 to 7% in 2008. Foods protective against AD include fruits, vegetables, grains, low-fat dairy products, legumes, and fish, whereas risk factors include meat, sweets, and high-fat dairy products. The evidence comes from ecological and observational studies as well as investigations of the mechanisms whereby dietary factors affect risk. The mechanisms linking dietary risk factors to AD are fairly well known and include increased oxidative stress from metal ions such as copper as well as from advanced glycation end products associated with high-temperature cooking, increased homocysteine concentrations, and cholesterol and its effects on amyloid beta, insulin resistance, and obesity. Lower 25-hydroxyvitamin D concentrations also are associated with increased risk of AD. In addition to reviewing the journal literature, a new ecological study was conducted using AD prevalence from
10 countries (Brazil, Chile, Cuba, Egypt, India, Mongolia, Nigeria, Republic of Korea, Sri Lanka, and the United States) along with dietary supply data 5, 10, and 15 years before the prevalence data. Dietary supply of meat or animal products less milk 5 years before AD prevalence had the highest correlations with AD prevalence in this study.
Thus, reducing meat consumption could significantly reduce the risk of

  • AD as well as of
  • several cancers,
  • iabetes mellitus type 2,
  • stroke, and,
  • likely, chronic kidney disease.


Teaching points
• Single-country ecological data can be used to find links between diet and AD because the national diet changes, such as during the nutrition transition to a Western diet.
• Multicountry ecological studies can be used to find links between dietary factors and risk of AD.
• Prospective observational studies are useful in linking dietary components and patterns to risk of AD.
• The most important dietary link to AD appears to be meat consumption, with eggs and high-fat dairy also contributing.
• Diets high in grains, fruits, vegetables, and fish are associated with reduced risk of AD, but these factors cannot counter the effects of meat, eggs, and high-fat dairy.
• Higher vitamin D status is associated with reduced risk of AD.
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Vitamin D Life - Alzheimers-Cognition - Overview


Increased Meat consumption in Japan - chart

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Chapter 26 - Japanese Perspectives on Dietary Patterns and Risk of Dementia - 2015
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Increased Dementia Deaths in Japan - Chart

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place of death trends among patients with dementia in Japan: a population-based observational study - 2019
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Being Patient

  • "In a recent study published in the American Journal of Clinical Nutrition, and the first-large scale study of its kind, scientists found that a 25g serving of processed meat a day correlates to a 44 percent increased risk in developing dementia."


Created by admin. Last Modification: Thursday February 10, 2022 02:56:54 GMT-0000 by admin. (Version 19)

Attached files

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16987 Dementia trends Japan.jpg admin 02 Feb, 2022 37.48 Kb 178
16986 Dementia trends Japan.jpg admin 02 Feb, 2022 37.48 Kb 86
16985 Japan meat.jpg admin 02 Feb, 2022 37.34 Kb 210
16984 Japan meat.pdf admin 02 Feb, 2022 213.44 Kb 163
16982 Alx meat chart.jpg admin 01 Feb, 2022 33.28 Kb 226
16981 Alz grant2016_CompressPdf.pdf admin 01 Feb, 2022 191.49 Kb 186